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LDANKLQQAVDQAYTQFHSLNGGQNADYIPFLANVPGQLAAVAIVTCDGNVYSAGDSDYRFALESISKVCTLALALEDVGPQAVQDKIGADPTGLPFNSVIALELHGGKPLSPLVNAGAIATTSLINAENVEQRWQRILHIQQQLAGEQVALSDEVNQSEQTTNFHNRAIAWLLYSAGYLYCDAMEACDVYTRQCSTLLNTIELATLGATLAAGGVNPLTHKRVLQADNVPYILAEMMMEGLYGRSGDWAYRVGLPGKSGVGGGILAVVPGVMGIAAFSPPLDEDGNSVRGQKMVASVAKQLGYNVFKG

       NPALQLHDWVERPFANGQSA--------NDSQLGICVLEPDGT-IHAGDWNVSFT--QISKVISFIAAC-SRGIPYVLDRVDVEPTGDAFNSIIRLEINKGKPFNP-INAGALTIASILPGESAYEKLEFLYSV-ETLIGK-PRIHEEVFRSEWETAHRNRALAYYLKETNFLEAEVEETLEVYLKQCA-ESTTEDIALIGLILAHDGYHPIRHEQVIPKDVAKLAKALLTCG--YNASGKYAAFVGVPAKSGVSGGIA-LVPPGCGIGIYGPAIDEYGNSLTGGL-LKH-AQEWELSIF

     SSPLQSFMETQMDQEKV--------------GKYMTATLVSATGEILATILYQSNYEPGSAFKVMMLAAAIDNNTF--PGGE------VFNDTGGR------MMTQGFSSNVGMTLLEQKM-------GDATWLDYLNRF-KFGQLP--------------------------------VN---IAQSSQGISVTQTQMIRAFTAIANDGVMLEIVGNPVSKDAASLTRTNMVLVG---TMYN-PTVTVVALKSGTAFSAVSMSNPDFILYVTVQQ-Y----GIQLGEFA-PILERAS

      VE--YE--DYS-FDKF-SA------------SGGFVLF-SNR--KKYRKESTSRFAPASTYKVFSALLALESGIIT--NDSH----------EWNQ------DQDLAMTTWYFQKLDRQI-------GEDHLRHYLKSIHYGNEDF------------------------------------VPADYWLDLQISPLEQVNILKKFYDNEF-------DFKQSNIETVKDSIR-----------LE-RVLSGKTGTSGWFIGYV--TFFFAVHIQG---AAG-SA-AEIALS---GIY

       ST--DI---VASFEG---------------TEGCFLYD--STNAEIKAKCATQMAPDSTF-IALSLMAFDAE-------IIDQ----I---WNSN-------HTPWMVVWVSQEITQKI----GLNKIKNYLKDFD-----GNQD-------GDER------------------------NGLTEAWLSLKISPEEQIQFLRKIINHN-------LPVKNSAIENTIENMY-----------LQ-TKLYGKTGANGWFEGFI--KYVFVSALTG--LTS-SIKAKKNAITILNLNL

                                          YAY-----TVA-YRADELFPMCSVFKTLSSAAVLRDLDNGFL-SR----------AP--GKPQNNGMT-VSIDNCAANLMLREL-------GPAAVTRFVRSL-DRVTRL--------------------------------------WE---TDTTSPRAITRTYGRLVLGD--------ALNPRDRRLLTSWLLAN---TTS------WTLGDKTGATNNDAGVT--PIVLTVLTARDD-----GLVADAA-LA--LG

           SDFAALEKAC----------------GRLGVTLLDTASGRRIGHRQDERFPMCSTFKSMLAATVLSQAE---LDRR---------HAP--VTRR-HAM-DATIDNTAANLLFGVV-------GPPAVTAFLRAS-DTVSR---------------------------------------LE---RDTTTPAAMAATLQRVVLGE--------VLQPASRQQLADWLIDN--ETGD------WRVGDKTGSARNDIAVL--PWVLTAYLQAYEQ---ASVLAQVG-IAD-IG

         LKQIES-IVI-----------------KATVGVAVW----LEPLLINPFEKFPMQSVFKLHLAMLVLHQVD-LN--------------W---PMKAYQ----YSVDNVACDLLFELV------GGPAALHDYIQSM-IKETAVEAQ----MHAD--------------------------------QNWTSMKGAAEILKKFEQKT--------QLSETSQALLWKWMVET--TTGP--K-AGTVVAHKTGTATNDLGII----LVAVFVK-NE-----AIIAQVAQTAYQFEL

              PQID--------------------ESYILIDYNSGKVLAEQNADVRRDPASLTKMMTSYVIGQAMK--FKETPVS---------------------QLISGNDACVAMADFAAG-SQDAFVGLMNSYVNAL-LKNTHF----------------------------------------TVHGQYSSARDMALIGQALIRD---------------VPNEYSIYKENRN-----GLLWDNVDGIKTGHTYNLVASA--RLISAVMGGRTF-----GR-EAESKKLLTWGF

     SSPLQSFMETQMDLEKVKG------------KYMTATLVSAKTGEILATTLYQSNYEPGSAMKVMTLASSIDNN---TF--PS-----GEY----------FNS----SSNVGMSLLEQKM-------GDATWLDYLKRFKFGVQLP------------------------------IVS----IAQSSQGISVTQTQMLRAFTAIANDGVMLEIVGNPVSKEAASTTRNHMILVG---------IITVAVKSGTAIFSAVTMNNPDFILYVTVQQ-YS---GIQLG-FA--ILERAS

             RSDWRFS--FQA------------KGTIV-----------PVRSKKRYSPASTF-IPHTLFALDAG---RDEFQI------A---GHNQ------DQDLAMTVWVYELFAKEI-------GDDKARRYLKKIDY-NADP--------------------------------------GDYWISLAISAQEQIAFLRKLYRNEL-------PFRVEHQRLVKDLMIV-------EA----WILRAKTGWMGWWVGWV--SV-FFALNIDTDL----FKREAIVRIL--EAL

 KFQQVEQDVKAIEVSLS---------------------ARIGVSVLDYWD---YNGNQRFPLTSTFKTIACAKLLYDAE---PNST----------YSP--EK--QV---ATMDNTAANIILSAV------GGPKGVTDFLRQI-DKETRLD-------------------------------------IE---RDTTTPKAIASTLNKFLFGS--------ALSEMNQKKLESWMVNN--QVTG--R--VLNIADRSGAARSITAVV--PIIVSIYLA-RN-----DAIVKIG-SIF-VY

                                 RIG--VFAIDT------SGNTYRSDERFPLCSSFKGFLAAAVLERVQ--DI-NQ---------HSP---TK--YKGM-AALDNGATNIIMERF-------GGEGMTKFMRSI-DNEFRL--------------------------------------WE----DTSTPKAVANSLNKLALGN--------VLNAKVKAIYQNWLKGN--TTG--VPAD-WVVGDKTGSTANDYAVI--PLIVSIYTTHS-----DKTIAEAS----RIAI

   QLTID--AKVQKSIYNN-----------------YGSGTAIHPQTGELLALVSFQITTSPGSTQKILTA-IGLNNK---LDDKTS-------YEV---VNG----NIDQAIDNIFFARVA-EL-------GSKKFEKG-KKL-GVGAQI---------------------------------NEI-LADSGYEILINPVQILSIYSALENNGNINAWKKNIISKENINLLTDG-QQV---KTHKE--YR-LIGKSGTAIGWFISYDK-PN--AINVKDVQGA----YNAKISGKVYDELY

   TKGIDEIKNLETDFN---------------------GRIGVYAL-------YRANERFPLCSSFKGFLAAAVLKGSQ--NL-NQ---------HSP--ITTKYNGM--AALDNGATNIILERYI------GGEGMTKFMRSI-DEDFRL---------------------------------------RW-DLDTSTPAAVAKSLKTLALGN--------ILSEHEKETYQTWLKGN---TTG----AAWVVGDKTGSTANDYAVV--PLIISVYTTHE-----DKVIAEAS----RIAI

           QPLEQIK------------------SGRVGMIEMDASGRTLTAWRADERFPMMSTFKVVLCGAVLAREQLER--KI----------YSP--EK--HLGM-AAIDNSAANLLLATV------GGPAGLTAFLRQI-DNVTRL-------------------------------------RWE---RDTTTPASMAATLRKLLTSQ--------RLSARSQRQLLQWMVDD--RVAGPLI--RWFIADKTGAARGIVAL----RIVVIYLRRN----------QQIAGIGAALI

         HPETLVKVKDAQL--------------GARVGYIELDNSGKILESFRPEERFPMMSTFKVLLCGAVLSRQE--QLGRR---------YSP--VTEKHLTG-ELCSDNTAANLLLTTI------GGPKELTAFLHNM-DHVTRL----------------------------------------DR-RDTTMPVAMATTLRKLLTGE---------LLTASRQQLIDWMEAD--KVA------ALFIADKSGASRGIIAAL--SRIVVIYTTTMD----NRQIAEIG-SLI-HW

               KP-TIA-----------------VGGYAM--GTGTTLYTKAADTRRSTGSTTKIMTAKVVLSNLNLDA--VTVRQ---------------------GLMGCDAAYALADKYGGSTRAARVKSFIGKMNTAATHNHFD----------------------------------------SFDGNYSTPRDLTKIASSAMK----------------NSTFRTVVKT---NTN-LS--YSGAIGVKTGSACLV-FAA-----IGTVLASTSI---REDATKIMNYG-FA

             WNKE-----------------NG--VFVLC--KSSKSC-ATNRASKEYLPASTF-IPNAIIGLETGKNE--HQVF---------AK---WE---RDLTLAIAVPVFQQIAREV-------GEVR-QKYLKKFSY-GNQN----SG------------------------------GIDKFWLQLRISAVNQVEFLESLYLNKL-------SASKENQLIVKEALV-----------TEEYLVHSKTGFVAWWVGWVEEVY-FFAFNDILP------LRKIP-TKIESGI

                 LE-----------------GGRLGVALINTADNSQILYRADERFAMCSTSKVMAAAAVLKQSE--HLLNQ----------YNAEKHV--NGTMELGADNTAMNKLIAHL-------GPDKVTAFARSL-DETFRLD------------------------------------RTA----DTTTPLAMAQTLKNLTLGK--------ALAETQRAQLVTWLKG------NTTG---RVVGDKTGS-TNDIAVI--PLVLVTYFTQ------RRR-LA---AAAKIVT

                                    QGRLGVALINT--NSQITYRGEERFAMASTSKVMAVAAVLKASE-GLLDKN--------YS---EKHL-TTGM-ELSTDNTAMNKILDYL---------AKVTQFARSI-DVTYR-------------------------------------------LDDTTSPIAMAKSLQALTLGD--------ALGQSQRQQLVTWLKG------NTTG----VVGDKTGS-TNDIAVI--PLILVVYFTQ-------RK--IA--AETKEISN

      MKELND----LEKKY----------------AHIGVYALDTSGKEVK-FNSDKRFAYASTSHAINSAILLEQVPYNKLNKK----------YSP-ILK---YDIALISDNTANNKIIKEIG------GIKKVKQRLKEL-DKVTNP--------------------------------------YE---KDTSTPAAFGKTLNKLIANG----------KLSNKKFLLDLMLNN---KS-------YKVADKSGQSRNDVAFV-EPIVLVIFTNPND-----KLISETAKSVM-EF

VSEKQLAEVVANTVTPLMKAQ----------------PGMAVAVIYQGKPHYYTFGPQTLFELGSISKTFTGVLGGDAIA-----RMLDATYT--------GLPQW---RL---ANASIGLFGALAVK-GM-PYEQAMTTVLKPLKLDHTWINV----VRVS-----------------------GMLDAQAYGV--KTNVQDMANWVMANMAPEN-----VADLKQ-GIALAQSWEML----------VEA--WVHKTGSFGSYVAFIPEQIGIVMLANTSYPN----ARVEAAYHILEALQ

PA--PD----DTGLQAVLHTA---------------APGAMVRVDDNG-TIHQLSTTTDRFRVGSVTKSFSAVVLLQLVDLD---TVVMSH-------DY---VTNAPG-AY--SNTNFVVAGMLILTGH--SVATEYQNRIFT--NLTDTF-DTV--TVS--W---------------------------AQSGAVISSTQDLDTFFSALMSGQ--------LMSAAQLAQMQQLRR-----------RDL-SVYGHTGTYYTYAFASKDKRSVTALANTSNV----TM-ARTLESAFCG

                LEKKY----------------AHIGVYALDTSGKEVK-FNSDKRFAYASTSKAINSAILLEQVPYNKLNKK----------YSP-ILK---YDIALISDNTANNKIIKEIG------GIKKVKQRLKEL-DKVTNP--------------------------------------YE---KDTSTPAAFGKTLNKLIANG----------KLSNKKFLLDLMLNN---KS-------YKVADKSGQSRNDVAF

 KFD--TSALEAFVRHIPQYK---------------GPGGVAVV---DGEVVLQHALDTRMPICSVSKQFTCAVLLDAVG--EP-AVRDNQ------WAL----FEP---SY--CNGNFR-LALI-HTGRT--LVDILSERFAPAGMKRAELI---SDT--RIQ-------------------------MG---AGICASLNDMIAWEQFIDATR-----------DESGRRLSG----LN----LH--ETG-RLTGHGGARCQRWH--ADRL-STIAMFGG-------ASEVAFKLMNIALG

KTEQQIADIVNRTITPLMQEQ---------------IPGMAVAIIYQGKPYYFTWVTQTLFELGSVSKTFNGVLGGDAIA---LLHLAT---------TA-GLPQWA-KR----ANSSIGLFGALAVK-SGMSYEEAMSKRVLHLKLAHTWIT-HVS-----PGQ-------------------------LDAEYGVKSSVIDMTRWVQANMDASQV----QELQQ-ELAQS---WEM--------SII---KAWVHKTGSFGSYVAFVPENLGIVMLANKSYPN---PVR--AAWRILEKLQ

       DDFAKLEEQF-------------------DAKLGIFALDTGNRTVT-YRPDERFAFASTIKALTVGVLLQQKSIEDLNQR---------YNP--ITEKHTGM-ELASDNTAQNLILKQIG------GPESLKKELRI--DEVTN--------------------------------------RFE---QDTSTARALATSLQAFALED---------KL--KRELLIDWMNTT--------GD-AG--DKTGAGSTRNDI-AIVVLAVLSSRAK--------YDDKLIAEATK

      PQQINDIVHRTITPQQ--------------IPGMAVAVI----KPYYFTWQQTLFELGSVSKTFTGVLGGDAIA--KL-TLLH---------TAGGLPAWA-------ANSSIGLFGALAPSGLS--FEQAMQTVFQPLKLNHTWNVPHV--SPGA----------------------------LDAEYGVKSTIEDMARWVQSNLKPLDI----NELQQ--GIQLAQ----SRWEM------VNP--WVHKTGAFGSYVAFIPEELGIVMLANKNYPN---PAR--AAWQILNAL

                 LE-----------------NVLIGLYAANLQSGRRITHRPDEMFAMCSTFKGYVAARVLQMAE--SLDNR---------NSP---TERAGAE-ELCAAANLLLKTIG---------GPAAVTAFARSVGDERTRL--------------------------------------WE----DTSTPAALAVGYRAILAGD--------ALSPPQRGLLEDWMRA------NQTS---RTTADKTGDYGNDAGIA--RLLLVMMTRS-------NL--LI--LT-ALVL

     AASLAARLDAVFDQA----------------LVGAVAIVAR---EIYRRAQEDTLFRLASVTKPIVALAVLRLVA--AL-TIHH-THT----YW---LS--FAP-GW--YSLALDVLG-VVATGQP----AAVDALVAQPLMRDCGFVSRV-A---------------------------------PSGAGMYGSADDVLRALEAIRANP-------GFLPETLADAARRDSAV----------AGTPQTLQWGGVYGHSWFVDRAGLSVLLLTNTAY---MSGPLTILR-AV-YA

                                                                                                                                    DLVLPS---SFR---VL-YFQLDV--TLAQLYHHWGSHFQ-----------AQKF-QGVR---LLRQDPIECLFSFICS---MVERLCQ------------------------------------------------RARYV---LRESS-----YEEAHKALCILPRSLWAGW

                                                                                                                                   WSWMLGFLAARAV------LFDLQ---CNPQIVNALGRLG-------------AARPGL---RLPGCVDAFEQGVRAILG---LTARVAQ------------------LYG---ERL-IC------------------PLKR---LPIPGD----VEQAMKT-LQTFP

                                             ITATPVDV-----------------NPDAVA----ASEIGRVCS-------------------EL----PWLSVILFLIRERS--------F--GILP----------TDS--TIY-VKEYVKNECLKLEQEIIFPPVTLDDFFWAFGI-----------------------------------------------------------------LRS--SRLEVYL--SL--DLNK

                                                                                                                                                                                                                                             MTLNLEERLAKLGKWQTQLPHFVLSVEASIGTP--GNLLASATAIN----VEEKLERQLNKLQHK

                      INDL------------------------------------DQLVHAHFEAKAALDAGATEAEMK-PIQDRHWRTAMD---------------AADARTKLARLLGI----THE--IQ--IP--D----------------------------------------------------STKEKAQQAIG

                      YEEF------------------------------------DNIGKAHLETGKAIEAGASDEELK-EVRKLH-AGSD----------------AQKARLLLVKILGV-----MD--YI--AP-------------------------------------------------------DTKDKAQKLAK

VPSIVTVKLLKNAIDANQGK-------------------NF--FPR-NEENN--FVDTKF------------------------------------------------------------VLFF--------------------------------------PEEVMTQRLLKRGESSGRSDDNIESIKKRFNTFN--------------------------------------VQTKLVIDYNDVENLFKSMG

 RELLVATQAVRKASLLTKRI----VISHSTT---TTG----------------------------------------------------------------------------DYAAQTIIINAIK---------KV------------------SGLSDAFVSGILNEIKANDEYN-FTNPLKS--EDVRQD---------------------GR-----KGR--------------IDGTKG------------IGCPAGGIHTDATKGVIASSG------------PRELHDLVVSTSC

                     FEREF------------------------------------DNIGKAHLETGKAMELGATDAELK-EIRTRH-SGNE----------------AQKARIKLVKVLYG-----ID--YV--AP-------------------------------------------------------ETKEKAQKLAK

  SDKGWEYLMSIFDQMAASH-----------------------GAKE-----EGV---VDRVYD--PP--LLH------HVEP---WT-----AVTV---------------------DI----------DED-DNL------------TIHAGESQAATAAS--NL------------------DLYQVN--S-ALGNDQHYIAARAVQFFL---------------PGVPQ--V---YY---------------GAGKN---------------HY---YS-----ENLKRVK

                                                                                                                                   RP--PLQEYVRKLLYKD-------------------------------------------EK----NVKYNSIHCVANLLAGL------------LYQ-EDVGIHVVDGVLER---------------RR-ISKFLYRM-----------------LVCTILDTCG---QY

        GSGKF---SFQD------IPE---------------------------------GPLKKLFVMV------RMSYITL-A---------------VADHF-------LCLLVLRILYAFAD-LSKEEVQKVLEDAH------PERKK----------------------------SYQEFVMLVL

                                                                DNVGRDWKRLARELKV--SE-AKMIEE---YPR----------------SLSERVRESLKVWAEKK--ASVAGLVKALRTCR---ADEEA

                                                                ENVPPRWKEFVKRGLSDHEIDRLEL-------------------QNG---LREAQYSMLATW-TPRREATLELLGRVLRDMDLLGLEEE--ALC

                           KL--NNYEP------------------------VYGETS-FDLVAQMIDE------------------------------------------LQVAAATNCKHH-------------------------EKAPAKYAETMDEFRKWMKWYGKKHAE--Y--L-------VNNF--K------LSP-------------------------------------------GS-----------------VSW----------------TGK

                                                                 VL--TQSAGDLLRAE----------------------------------------------IKN----EGQIV-PQKMDQAI---------------PEDIMLERLLERGKTSGRSDDNIESIKKRFNTFKMPVYF-----------------------------------------YKDVQDAIRDSL

                                                                                                                                                                                                                                             MTMN-RQVA-DRLAKLELPHIILSVADATINTPNGVLVASGKHDMY---AINELINKLERQLNKLQ

                                                                                                                                                                                           TGAVTQ-----------AA--II-GHDGNTWA----PA---ALANAFDA------TIR---------RSVYGKKGSAGVITVKKAILIGVYNE---------IQPGTAANVVEKLAD

                                                                   SIIIT--NVSTLN--YDV---------------------------------------KDF------------SLL------------------------------------------------------EERQRAIKILANSFYGYY--------RW-CKECAESVTAWGREY-----MVI---YADT---------------------------KYIN----EYEG-------------KK

                                                                                                                                            KMVNKQAP-YR-----FITNVQNGVVFWNQYEDALN--RAWVPPEIIVGIIGVETR-RV---GKTRILDA------LATLSSGETFLLMARD-----------EQ---------DPGAM---------------QFAVDFSGD--GH

                                                              VEI------------------------------TDYR---------------LLEFFFQIHD---------TKDRQY--------------------F--QKRIALDTIADVEASGLWPGKV--VTE--------EAEPEHQDYLQRYP--NG--------YT

CSDTAAPLAAVDLKWE-----------------LG---------PGCV-AAPVDEYALTTRGPSHVKLGDFVTALHRRLGW--------ALVLYADCSSPDAFRNLM-FF----LDV-------------------------------------------------FGQSLKP---FQAKFTVEDG----------------------------------------IIPASFHDGLLL---YVQAV---VTDG-------LKID------------RN

                                                      KASAA-------AVLRQILDIWLA------------------AFREDFA-----LAAIKEY-----------------------KL-----PQRLFC-LMDELTGLKALIDEKSALIAGWVKKLA--IDPQHLIF-IWASTQHYATLRDEVFFN

                KAG--SGVSGG--EDGARYGIAAKV------------TG-------GIEY-----------------------------------------------GDMQLICEAYHLM--LGHKEMAKAFEEWNKTEGW-TLNYGG--ALMWRGGCI-------------------------------------AV--CQDSWRRA

                                                                                               GPFV-L----LLCKL--------IKIQLLADLN---LPPEKVLLKWMNFHL--KTVSN-------PFRKENCNQVIKIGKQLKFSLVN--VAG---------------------------RTMG-----ETDDEKRLN---IVS---KLGCS-----FLLP-----------DIVE-VNQIL----SLQR

                       KKQGQ------VHP----------------------------LILQLLN-LCQ-------------------------------------------------QPR-SASDVEERVQKSFP----HPIWA----------SL--PVEKIHPL----GYKIDHQVSVYIVAVLEYI--------------------------------------------------------------SAIL--------------LAGIT-----KQDIKV

        RLAKELDNLK-AI-----------------NNL----TL-LQDYLLMTV--------NFWGGMTQYMAWIEGEP------QDPN----------------EW-------FMAKSAS--------RS--KAQQEYRKT-LE-WQ------------------NSQ-----------TAEEKQI---------------------------------------YIDWVHAAAAYI--TLDAHHL---VS------------SGSEG

              NN---IG---S---GQ--EICE-GDYS-------------DNRYG-DPDG--CD--WNRL-G---NTSFYFTL-------LTVVYVGVT--------------------QPNSG-----NDDYCTAEEAEFGG-SSFSKGQFKKATSGG---------------------------------VLV--------YP--ETSST-------------V--RGS--------------GVP-----------------SPN---TFSNI

                                                                                             KFGLF----HYVDQ---DT--AV----------------------------------------HFS--NNG-----------------------VGAP-----VTTFSECHKIINDAFTTG-YCHPPKISVNPH--AFT-GPA--------------------QFVNA------------------TS------VVEWAAKLG

           KATK-DA-----LK-------------------------------------EALKTYEKYRADINKKINAKDRAAIA----------SLADI------GKAVW--RPLFVKTETIIAGN--------------------------------AATALVALVFSILTGS------------------------------------------------------------------------------------------------------------LGIGYGLLMAVTGALID

 EQKNEFKAAFDIFVLGAE-------------------KEL---------------------------KV-MRGQNP--TPEELQ-----------------------------------------------------------------------------EMIDEVDE------------DEFLVMMVRSMKDSKGKTEEELSDLFRMFD-----------------KNIMLQAT---------DD-IEELM--------------------------------------------DKNNDG

                                                                   YPKS--GTT--WMIEI-PSWI-LM-----IFTKAFFSSKAKV-----------YMG----------NPRDVVVSLYHYSKPGFLRD--KG----------G-WLRMKGKDFLFI----------------------YEELLLD--H-------RGAFL

 TKEHKDKRQAEILEAA-----------KTVF--STE---------------------FRIEGL-DEGLRKLDKSA-----------------------EHQS---------------------------VWASISSYLDELTEGL-EYLV-LEK---RYDLFVERFSRLLQKGIDQGEFQPPLATIAKFFLN-NDGQNYFD-EEKAD

   EKYLNE-----MQVP----------------------IE-------------------KIV--IN-----------------------------------------------------GVG----KALDSAVEELTLIA-------GQR----TRAKRQ----------------------MPI--GA---KVTLRMYEFLDKLISVSLPRA-----------RD-----VS--KKS-FDG-----------------RGNYTLGIKEQMDIVIVT--TANT------ARLLALLGM-----QK

                                                                             YQAVEVPG----RVFRFE----------------HQ--------E--GLV-IAMAHLKGAIYELAQALFGPDSKV-------QP-----VY----------FPF--VEPGA---QF--AVWWPE----------------------------------VE-------------------AM------LRY-FKGV

                                                             ALGAGRGRGIAI--------------ASAQG-----LFD-AV--GGLD----------VM----SG-KVFNLNTRGQFFVAQQGLK-------------------------HC-RRGGR--YAGSKAAVEGFCRAFVDCGAKGV---------------------------VSALCQ----------------EESEIN

TSEAELLELIDTLNADN------------LP--PALERIHP---------------DKDVD-CTPRGIVTLLERYN-------------LNAVTVT----LHV-EN---ADL--IV-VID-------------------------------------------IN--GDVVF--EDARA------PVPGGVGPMTVALNT

                 RSLL--------------------------RRD---------SVSA-------LGDPLS-PE---------------------------YDL-TC----GVENYARYFTGKAPGE---PPYT--LLDYF------LQGMYRGDYARKTL-VGFRL-------------PSALDNRP-------------LIRDLRLGH

                                                                                                                                   QTYVD----------LVGTGA------------------------------------------------TQ--AA--IL-GLDGNTWA----PA---TLAGAFNA----TL---R--------RSIYGKKGSSGVITVKKAILVGVYNE---------QPGTAANVVEK-AD

                                                                                                                                       FLTD--------EVL-----------------------------------------------VEETVVRDKAVESLRAI------------EH--LAHFVPLVKRLAG---------------GDW-FTSACGSV------------------TPMVRRAAASKL-GEFA--LE

                                                                 RRDKYFFQKLSEKYKLKELALI-----------------------------FISNLVANQD---------------------------------------------------DISDADALVFYREYIGRLKQKFE--I-----F--EYSSYI----------LVWNNYSIKLKAYRKI------------------------------------------NID

                                QGP----QTT---SAYR-----------ALCLDL----------------LSLSAAC-------------------ALD------------------------------------------------DILQINCLTTIYDRLEQEH--LVNVPLCVDMCLNWLLNT------------------------------HLEDKYRYLF------------------------HDSI------SFGGSN------------I--PSVR-SCFQPEIE

 DNLERMVSILSFVAVRL---------------------------------------------LTPECQLLGYLDK-----GK---RKR-------------------KEKA-GSLQWAYMAIARLGG-ALWEGWEALQSKLDGFLA

                                                                                                                                                                                                        QL--AV--FT----PQGQV------KKFS-EIQINPV-RKSV---ANAN--TDGFDFNLLTFNALFYLNKQPELYFVVTFAQTL---NQ-TQQTLALVLKLWNLS--LK

                                                                      FLSFFEKKG---TR----VKSAPLFVNA----------PF--SCQ---------GNFSYFKKEAIEYAWEFVTEVLKLPKLYVSERIRL------EDN--FW--QG-------CGP-----SS--EIYVR-GVI-------------EG---RFGYNPFLYKGVDLVVDI--KEPYPELE--LSR-------------VKGI------------TLK-------------GFQGKT

                                                                                                                                  MFK-----------KYSSL-TN-FF-YEIILKNYADSIKAVQDIMETSAVVS----Y--QV--FGEF---------------------------------------------------------------VFDPLLGRGKFEEL---VVQDFTAGL

SNLADALTDAGKLAGAMTLKVS---NS--VFGRSLE----------------------GAG-TTAVGVFEAMKATVAHRGL-SLDGLT-VLLVAD---AVAGHEDVL----FA-PC-----------------------------------------------------MGGVITTEVA-------PDFVANAGGAIHES-VVHERA

                                                             KAKQYLEEFHQTALEHP-----------------ANYA---------------AWAVNVAQVID-SE-DNLEKT--A------------------------AIALSSLMVAQAIPL-VGELVDYNFVESIINLFQVNSYAY------------------------------------------------DGY------------------------------------------AVS--IKITAENT

                                    ASI-------------------------------------VQKIMAYLQQEQS----------------QEKLS----AFGLLCKMADQTSIVWSELLILDHIYRQVAHGK------------VA-------------------------------LL------QELVVR--------------------------------LL----YTVCNYP-QQTEK

                                HVSP--WRSEE-------------------TNEAIINAYLEVERALVCCEKV-----A---------------------SVSADE--SLV--VHYG-----TSNDIIDTAWALLI----------------------------RRA------------------------------------GRT------PITLGFKFANYYYELYI-----QL-LM---AAV-----------RLEIR

             CQET-VCGKKPE-----------------------------------AAYVTKGLGQIATRLRAEGKA--VD----HR--------------------GNLTCAAKKELAASLTD-----KSG-LS-----------------------------------------------------DAAAKGT--LRWLI-------TLDD--LVAL--TG--------LLDAANT----------------DLRDL----------------LLK-------YT--MLP

                                                                                                                                      SFE--YL---IAS--PSTSNPD-----------------FNT------LAKAVEYYINTSYNLQRFDD-NHKYVGYWDS-------GFDL-TSLVQQKALAYAVDIA-SFDDGDFA---NTL--------------------------------------------------SST

         PEKE------ERAATLLKKWVPK-----------------------------PICGNDVSTLKELAARWKP--EILEGFKKEN---DIR---------------ESIKELAYYREHF

                                         PIFGI-------IDI----DRRYRSWVEANRRYVHERSKGTIGYQGL--------GGSQLIIEKLM--------------------------------------------------------GSDGDIFSFSFKKGLGK--IGT---------------DPQIDYAIDALIEE

                                                                                                                                       SYVDDHL---------------------------CD------------EGNH---------------TAAA-----LGQDGSV-----PQ----IKKDFPG---AVI-----QGEQ---AVIRGKKGPGGVTIKKQALVFGFYDE---------MTGGQCNLVVERLGD

                                                               SL-NFG----ALDECKKLT--------NED--EIKNR--------------TGCAIMCLSTKLN------HHGNAMEFAKKHGADEMAQQ-DIVHGCEKSTP------AN---DDKC------------------------------------------------------------------------IWT----------------------------------GVATCFKAEIHKLWAPS

                                                              NTDVLAEKAVQ-----------CHIL-------TLKLIDRWSQTL-------------AYV----------------------------------NPKIKGLPLIQQFEHIFHFMGMSFK----G--YVL--GE-IL

                                                                                                                                                                  QTYEH--------------------LML----------AA--SA--IV-GHDGSVWA----PQ---TIMKDFPG----VI-----QGEA---AVIRGKKGSGGITIKKQALVFGIYEE---------VTPGQCNMVVERLGD

DTSEVRGEQLLQQVEEIVALS----------------PKVNLIGHS---GPT-----------------------IRYVAT-------------------VGA---HKG------SDTADF-------------------------------EAVLSGLVNSLGLISFLSSG-----------ST--GT---QNSLGLENSEGAARFNAKYP--IPTS---------YYSW-----SG------PLT-------------------------------------ASSL--K--NG

                                                                                 DFSRRYR----------SSQ-------------------------LHLTPFTARGRFATVVEELFR---------------------------VN-------------------------------------------------RIVAFFEFGGVMCVESVNREMSPLVDNI---------------WMEY----NGG--------WDAFVE

                                                                 LWLRSV--FITP-ANVVFLYMLCR---SEVGHE----------------QAVLLTCLYLSYNEISY---------------------------------SCKEAFWDRCLSVI--------------------------SKMLQ---------------------------------------------------------NADPHY

 NEQETFRA----------------------------------------------------------------------KVDEIWFRLTDGTV---------------------RDFLIEKAAEYF-QPEQ------------------------------------------------------PKQNAIEVIS-------TFDGW-FDQNEPNCLIL------------------------------------------------KTPTGIRKIWNKPL--------YL-SW-DKYFEMKPI

GDSTAFAEKAKSVG--A--ENED----------II----------------------------GLKGVAAYAEHAAVLGFR-------KTE----KGR----------------MAVTTMALLDEANTNP--------GHD-LTT----NC---------------NKL---NLG---DIGG-----------------------------------------DA-------IALKL---------LLALLFLG

           KGT--------------------------TE-----------DIARKKAVVLRHSTAHLMAHAIKRLYG-NVKF--------------------------GVGPFYY--------DF----EQEKTMKQIVNENTA--IKEDKKELK-SYR--------------------------------------------------------------EKYF-DDDMWNKAENMLKEAA------EEAI--ME-----RF---------VAF

                  GARE-ELGAA---EV----------------------------------------------------------------VVAEWFDK--------TAVAVRS----MAEK----PYR-----------SP--LPSQAERDMYNQGALFGDAVNSHRASIG--LPPV----EHLYDY-DQ---SPL---VQT-------WI-------------------------------RPATA---------------RG------------------SAGTTLLA

                                                          WVGSAYL------------------SSLD-------------------------------------V----QKVAVYRALQAALAESGGSPLQMLK------------S--DP-------------------LI--VQLRFCGRFLRAYRE----GA--------LRA-----QL-------------------------ELRARLLLA--------EELSC-----------IL---QP--DRLR

                                                                    GIGRAIAETLAA--KVI---KGLML--NVTDPASIESVLE--------------------------------KIRAEFGEVDILVN----TN---LSSVFRLSKAVMRA----GRI-----IT--IGSVVGT---MTR------AL-----------------------------------------RL-------GG---------AQENA----------------AFLA------TGE

LTAETAYWIGRAIGSESLQIQ----PENLKD------AKVK-------------AE--TGTIIYPRLLMLFAKDVVSRNPGAD----IIPVMWKT--GHSLIK----KKM--AGE---VFF--KE--------RLLEILS-------RDS------------------------------------------------EH---FSAFPNI-------------TVTEDSKFAIIEALQRDAQW----ITT---LDGV-------WGLVRAS--LRFEAD

                       DTL-----PARVA-V-K--------------------DFKAI-HIE------------------------------------------EL-----------YRKVRGDKKAIEALIEKLREDTPEGS-VIEI-----ISPGKVITTHV------------GPGT-VG----FGIEVL

    DMW-----LV---AQ-GLSHTFAFRRY---------SE-RM------KVKVR---------GVYVALMMAQIEI-IINESIE-----------------------------------------------------------------AVDSLNPFM----------------VD--SKWAPRFDYILSQALVAAPI---NQDLISNFLSD-------------PVH

                      SGI-----------MLRDE-----------------GRAV---IVAKKVNEILQADAI---AGQWLA---------------------YGVTRSV------------------------------------------KEFGFQQVLEDIQPAIDSGKGLMFPNQAAGYMAKLIWESV-----EAMNWLKSAA-IAFVHS

                                                                                                                                                                  NSKLRPEVMQDLLE--STGTIDFREFIIALSVTRGKL------------------------YISKAEMLEIVQAIYKM-----VS-SVMKMST-------------RTEKI

                         YV-----DLIS----------------------STTYV-INGMAEVIKTAAISSE-EEFTA--ENAETKAVR-RFEGT----EIL---------ILASARHKAY---V------LN-HSIGH------------------------------------------------------IEC--VAIGMVKEA-----------------------------------------------------------------YGLPT--SLKDIR

                                                           EGG---LRSALSLSMITG-------------------------------------------QPF---VRGGDY--------------------IGSAGGGT--PADFIRRVLEPLLAKIGI-HQQT---------------------------AGV---------------------------IATLAGSF-HEQ-------NTVSLEVESENITERFFVVG-AE---AAQLVKEVKRYLAST

                                                               VMT-LSQVKGFVRKGVNEAKIDEIKN--------------------DNV-DTAEQKVQLLRNWLHG---A-YDTLIKDLKKLC------------TLAEK

                                                                            EHEKYAAHTTR---------------------------------LAF--PQLG---SNEDAVIRRCRYELGVEITP----E----------YRA---NE-------VCPV--------FAART---L-----IN--DDE----------------------------------------------------M-----DYQWCDLADLHGI

                                  HWPDNFSI---------------TIQPPY---NLF---------------------------KFQKP-------------RFKEYLSAVNQLAK----SVIHLAVRWILDQPGADIALWG----------------------------------------------SE----------------------QK-----T---E--SDPV----------------GPE

                                                                                                                                                                      CD---------------DGHR----LT------AAA------I--GHDGS--A----SD----A--VMKD-PG-VI--QG--EP---GAVIRGKKGGITVKRT--QALIIGIYLT------PGQCNMIVERLGDYLL

                                                               NG-VMRVLSRL----------------------KCS---------------TRKRFEQIVREIMAENPGAFNEALIELGALVC--------------------------------------------------------TPRRP-------CL-----LCPVQ--CQA------------------------ELPV

                                                                                             MKFGN-S-EGCG---------TV---------------------------------------HHFT--EFG---------------------------LGNP-VLPMDCWYDLMKEGFNEG-YIAAPKIQLNP---SAYTQ---------------------APVYVV------------------AE-------TEWAAERG

 GMAR----------IAPV----PDA-------------PIEKDL------------R--------------EI-ELVPKPNVFRIALR-------------------AIK--GGAWAMLVARICQL--NWPQ--PLKPI--E----DGVWNPKAQDRSHRS-KKVILQEFVRGVQITN

                                                                 EIAVRIIRACKELGIP--TV----AYMIGDTYLNKQRI----NLA-------IHP-------------------------------------------E--NAEFAKMCEEAGIT------IGP--EL------------------------------------------DGV-------LKS------------YPVLLKATAGG--RGIRICRNE-----LVKNYEQASREAEKAFGR

                       EL----AVH-----------------------------KDAF--SLRRQCQLAERRP--DLI---IR-----GNVRLSKLDNG--DA-------IIL-------------PPEISL------------VG---GAV--------------ECRL-------------------------------------------------------------------NT-EGG----VPIGSYAWLRALVGAPDSQIIRGERRDAEQ---GISLAEELLNNGR--EILVYN

                          RS-EKG--TEG----------------------------CSLLCMRL-------RG---KL------------------------------------------STMQQLGSLMALDVIVNNSDRNLD---------RTL--SSQFHSIRDII--YDSMQEGFLATVRECASFDLDAFERELLSWQES----------------------------------------SPAIPF------------------LRM

                       HNRP---LTCI-----------------------DTFMMTL-DVAQST--LLSTPALDA----------------------------TDEILA------------------------------------SVLENHHLAVGFL---DIFMNLT----KK-----QR-KMVIDMVLASKHMSLLADLKTMVET----------KK----LLL-DRIMEEFFQQG---DKHTAS-------------SQ--VGF----------------YQSM-IPRD----ME

                            DLPG-------------------------------DANFVRVI--------YF--------G---------------------SYNHKALWELAETLVPGGKCRDFNLGLMDFSAIIC--------------------------------------------------------APRKP-----K-CE-----KCGMSKLCS-Y-------------------------------------KC

         RQQDGDY-SYL-VLPD------------------------------------------------------AWHNNIRAEL------------------------KLA----AI---------------------------------G-RHHPQEIMQICEEVAAVIEREGHHTSAEDLRDYVMQVIDATAEN--RALR-RA----RAH----GIAV

                                LAYDLMAK---------------RD-----------------------IDEWTKYC----------------KA---YYN---SMMILK--------ASE--YIA-VWS--------------------RDLYHVANAFIAAG-------DVDSANRSLDYLAKVDNG-----FIIKIGPK--T----GQER-TMAAEVAGLTCAAYIA--QNKDYES---QKY-WYR--WPLLTYE--IA-----SEQVWE

                          LPV------------------------------KA-MG--VYHSLKGIIKKKYGQDAVN---VG-------------------------DEGG---FAP-PIKDINEPLPILMEAIEEAGHRGKFA----VS--IE-VGD

                                                                GAVGMACAISILMK-ELADEI---AIVSG--------KDY---NVT----------VVI-------------------------------ESRLNLVQRNNIFKFIIPNIVKYS-CKL-------VVSN-----------PVD---GC-------------------------------------RY----HGW-----------ILGEHG

                                                                                                                                                                                   DEQSGRDLQQYQSQAKQLKL------------------------------NEQSP--------------------RCTLEAGATFHYIIEQGVCYLVLCEAA--------FPKKLAFAYLEDLS-VP

                                                                                   FETRF----------DLAAQ-------------------------VTPGSAQQRFTQVSDELFQ---------------FFVFGAALCAESV----NKEMEPLVGQVQEWMVEYTRDW-----------------------------------------------YGDGAAR-------------REGN-------------SVR

AN--SHWRNVLLQL----------------------VTP-------FGHSPTM-SGFKN---RVLMHYVRAAEMLSAWHSWDG--ARIER-----RMQ----------------ALKACQMVMQQSVY--------------------------------------------------SFSYF---TLDIIFK-------------------------------------LL----------------------EISLRVGNGPTLAFSEQ-LKSIQLT--------QDS---PH

                                                                                                  LSQAN------------------------------------TGGVQS-----TL-------NE------LLAY-SG----YGDTDARVTAAIASNIWAAY--------------------------RNGN----------------------SL-KFILMDCMEGRVAITR-LLLCMYAKET---------VGFGMLKAKAQAL-VQ

                                                               ELQ-VDQLWDVLLELFRPHMIE-DIQR------------------AGSG-SRRDQARQLIIDLRGS---QALPLFISCLEDTG---DMLTN

                                      EQK-----------------AKANFD---HPDAF------------VYDF-VLF----AFVRDLF--QMKL--------------VDT---DADTRLSRRVLRDISERGRDQILSITFV--PA--EEFCLPTKKYA--DVIIPR----------------------------------------------------------------------------------LIV---------------------------IQDILN

                                                                      ALDILAENDECLAFMR-ASSVSLPFPITS-----FKL-TSVF-LYYEDLVS---CVNR-EA----EAVSMLVKEAVVDALVT-----------------------------------GGF---DFLIT-EQQLLHKVTDFWKQQG----------------LYCRK--------ERDLRRY-ATMM---H-----ALYDRTKRVFLEAE-----------SEEEIFAHLG

                YANACDS--------------PDFF-------------------EDILQLIRAVYDTLSNKLG---------------------------------------------NP--FHLEEVFKVIEEIVSVLVQ-QKID---KY--FTE----N-------------------------------------QRYS-IM--TQ---------ADH

                                      RYSLSP------------------TEEAKYRRWLEVELAVTR-GVTER----------------------------------------------------------------------IRNNAKIDVELFKKIEEKTN------VAFVEGIGSMIG-----------------------------------------LTSSDVL--DT

                  IFRLF-------------DSL---------------------MRAGALAQQKLTRAIISALDPY-ISWRTL-------NITVS---QQPEK--YLLL----G-------------------------------IDPAGADEHWKTANTALTIRN---EKGLS---T--IF--IGANSANLKT

                                                                 EIALRILRACKELGI--KTV----TVCIGKSYLNIPAI----ISAA------IHP-------------------------------------------E--NANFAEQVERSGFI------IG------------------------------------------SAIA-DGP-------LGD-----------AK--IIKASG--GG-GMRVVRGD-----LAQSISMTRAEAKAAFSN

                                                                                                                                VLKSKILRLLCTVARL-------LL--------------------------NARNYNFGGEFVEAMIRQESL-NNYNEAV-------------CH----------LPWVG------EMDRIFANT----------------------------------------------RQKDCLWA

                                                                                                         VVMT-----LCYPAARYLM----------------------------------VLG---------------------AMLAAIRRVYGLLANYLQCGGS--WREDW----GQ------LS--NGDLY-NVFAW-AL---------------DVLRLRS

                              APNAGKPVE-------------------S---ATGRGVKVCAGLAMDVLGIKKLGSK---VVAVSD-IRY-TNEEL-LE--------LV-----------------------------------------------LEGAIH---AERI-LS-------PDILANAVTVEKILAIDRVA--------------------------------YATKKRG

                            ELP----RRL------------------------IY------------------------------------------------DF---PTAEYVANAVL-HLKALADVLV-----------------YDGEL----FGRATVRRIL--KRARAAVDLYNKLICRATEEEKAD--EKGGE

                                                                                                                                       QHLGVVTAT------------------------------------------T--DLQDYTY---------KLLRLLQ-------------VRGRLTECLETILNKAQEP---------------HS-NANAISLIIH----------------ETNLRYLALESMCTL

 NIFHMSLLACAL--VMATYS----------------KAF----------KHL--EHRIES----L--TLCERLLS-------E---HP----------------------ELEHI---IC--IDL-------KFKIIVTAYKDLPHAVQTFVLI-FVFMQRLKTNILQYA------------------------------------------------------STRP

                                                                                                 FKV----------TQYV---EM-FRAFDTN-----------------------------------------------------TIDFLEYVAALNLVLRGT--------------------------IDRQELLDIVESIYKLK--CS--VEVE-----------------VVDRWVM-LNP

                                                                                        NVGIKEKL-V------CVGNE--------------------LSLLAFLYLYLAICRKQRTLPSLDI-----------------------------GSS-----CVAA--------------------------IGSWPEEDLKSINKWAYE-GERVIHGNPS---VDN-----------VSWGGAL----------LTNTKVP

                                                             GVPET-SKKLFE----WIPVVANARAYLQNGE------------------PFADFV-----------------------------------------T-IP-TPASDALSKALK-KRGFKFVGTTICYSFMQACG

                      VI--LPV------------------------------GA---GTVYHHLKAVIKARFGL-DA---AV--------------------------DEGG---FAP-NILNNKDALDLIQEAIKKAGYTGKIE-IVSIIV--GD

 ISANAANIVKEAVAKSLLYS--------GNMY-------CI------------------------------------------------------------------------RDLDYYLRYATYAAGDPSILDER-------------------LKET--PIGATVQAIQAMKEVT----------------------------------------------------------------GLVGGGAGKEMIYF------------ICSG

                                                                                                                                                                     KLSKDDLTCLKQS-TYFDRREIQQWHKGFLRD--------------------------QPFGSPEDFANHLFTVF--DNNGGSM--EATP-------------RVKKSIIG

                       DKN---------------------------------------------------------------E-----EILLLKVLDDV--RP-------ITIHITI---------PTREIVEEMKKNGI--PAV-------AGTYNFAMYLTLHTSATKGYKI-----AGF-----IH-MSL

                                                   TG---DGKRILVS---GISIAFHIARVAQ--QLV---PLLEL--DVQNEEHLASLAGR-----------VVH--GFMPDVSKGIHIS-------------------------AYSYASMAKALLPIM--SIAYNW-TV----LESVFVAGK---LAMSAIVGGA---------LGEEAGAQIQL------EGWD--GW--------------------------KDATAKTGGA

        RCF---IR-ALS--------------------LPA-----LG------------PPQYALELLTVYAWEQGSRK--FSQG-----------------------------F--TVLE-------QK-LCI-PVILDPADPTGNGGD---TH--R-----ARVWLGY---LVGA

                                                            GEPYIVHPIQVAGILADLH---LDAVTVA--------ITLDNIEFGKDVR------------VK-----KRRE-RE-LVDDIVTKIK-VYGRP--KHIYSIYRKMRDKKKR---------------FDQIFDLI-AIRCVM---AMVGYIHE-----------LWR---------MP--GR----------------FK---QSI-------------TKEM

                                                NVKK----------ALGVEDKVTVPLFEGVQK------------TQT-------------------------------IR-----SASDIRDVFINAGIKEEYDWNSFVKSLVAQQ--AA------LRGVP

                       FYTWTR-------------------------------------------DSGLV---------------------IKTLVDLFR--LST----IEH------YISS-AII-QG---------------SN-PSGLGE--GPALRATAMIGWLLDN----AATIVWPLVRNDLSYYWNQTG-----DL----WEEVN------TIAVQHRALVEGSAFATAVGS-------SWC----SQQIL------------------------CYLQSFW--TG--SYRALA

                                                         YASA---DELVWAAA----ATN-------------QNWGGGSGVQVLLAK-YKDT--SYVNY-----------------------------------TPKGLL--LAANAAFIMLEAAELGLSASSYRQFA

                                                                                                               QV----------------SWKLVTEYAME-----CD-ANA------------------IF-----------QKTICQQAVDTVLAKVDTREQMLTNRFNDLLDR----------DIM-----------------LPKMDSVAAA-----------LEL-----C-------LGV-AI--FLV

                                                                 VIVLNIDNIL--------------------------------------------------DGNKNWTEQEQSILEQTASSLQ--------------------------GWA------LMIKQSVWSSAIAATHLK

                      SSLP---------------------------------KG--WHT-NPK--SGTT--WLKAL--HPLLM------SLPESVKSSSCKI-----------YCC----------NPKDMFVSLWHFGK--AVAFCEG-----------E--WYASPNKVLFVT----------------------EELKK----EVE-----CG

       HAVS-----------------------------PM----------DVALAKA-GLIRHSCAHLLGHAIKQLWP--HTK--------------------------AIGPYYD---------A-----LEKRMHELAEKYD--RFHHDKKALNT--EGAFY---LPSRLSA-SY--PVM-----IH------------LT---FPLA---------------------------MN-VNE---VK----YM---------------GKDL---------------DVNEVIEKLQQEI

                                                          ATFYEVDRI-RVFLYEWNKFSKQE------------------------------HL----TLV----------GRYVSQIRAQLVKVVFQGIEPQIN-------------------------------D---VAIT-NKVVDSGYIPAYLLPKV------------------QPELQ--------------------WAWT-------------------------------NLDEYK--KR

                                                                                              QF--------------STYA------FNAFDTT-----------------------------------------------------GSVKFEDFVTALSILLGTV------------------------YINKEEMMDIVKAIYDM-----MG---------------------HVDVFSLQL

                            VALMEKNG------------------------DLYELALLRFA----MDM-FL-MTLP-AAPAFRSEAG------------------------EQY-----AFQELLENAEEILRLLEL-PYRLVE-----VATGDMG-------------------------------------------------------------------------------------PGKWRQVDIEVTHSCSALL-YTLNNTTP------ILAM

                                                                    YELF--------------------ISS-FKT--KK--------LF--ADRVFDLFD--------------------------------------------------------HNLGFEEFARALSVFHAPI---DKIH-SFQL------------GF---IERQEVKQMVVATLA-GMN---------------------KTFEEARHP-----------LLKN

                        PPVHE-----------------------NKMK--VDEMVTV------------VIGLSKINR-IVQ-------------------------------FF-AQR-QVQERLTQQILIALQTLLGTNNVATRHEFLRAVRHHN

                                               ELLKHKV--IASCFAGHPTQTLLDLFTIQETQGR--LDNLLAKF------YILDMLDEIAW---------------Y--KV-----LHFQQAGNG-IF

     TLDAFLEKKKQAG-LKV-----------------ALYGGGVPGLPEI-AGAV------------------------------------------FQEIAACG-----LH-------SNPDG------------QYLNI-----YMKVA-------------------------VRSEMNIRLWEQLE-ID--GAL--GLETSLPMM---LT-------NGVNLSLERLVEVMCEKPAFGIYPQKGSDADL-------------ILDPV------------------------MVGTV

                                                                                                                                                                         DL-------QF--ERSSVGQFMTF------FAETVASRT--GA-------------------------------------------ERQSIEYIGHVYARSEGICGVLITDKQY--PV---AYTLLNKILDEYLKE

                                           PVE----PDLKFG------GP-GKTLLAK---NECQA--NFI------------------------------------G--PELTMWFGESEANVREIFDKARQ--------------------ARGGN-----------GDGGGAADRVINQITEMDNVF

QFQRPAWDGYLRVNALLADKL--------------II----HLGIEP----------------------------LPLKALKNVQ----------AYEALEK--PQ-HG-KIR----YT--------------------------------TSRG--QDIRHQLNEAGRINGKYGQLGWT---------YL-N---------LVKEYVAAQ--D----------------N--PG--------------------VLVL---------------------------SQF-AANELTLTMSLAERIRHA

ILTDNRERIVKQAGDQLFQKR--------GNAY-------------------------------------------------------------TATC----------------RDLDYYLRLITYVAGDVTPIEE-IG----------------GVREM---IDAVAAGVSAMKNVA----YFDYVA

                                  RDKEPKE-------------------YAD--ILIEEALNEL-PF-FYSKI-----VRIG-----KIEKL-----I--------VML----------------------------------------CATAGSVCKAIEVLLRLGVKEE-YPKV--RM--VTAA

                                                                                                                                                        HSKFLET----MEELYQNYRNAVIES---EIVLSNMTVALDRILLPFV---FS--HHK-------------------------FD------LLEKTNP----VAGLADP----CV-----------YS-------------TKRKANT

                           NMKAP-------------------------------------KGTDYQL----SKEYTLDVY-------------------RLS---LYPGLQALDEEYLK--------------------------------GIDQRKIFTFAEKYLPAL------------------------------------------GYSK-----------LM--NPMVP--GVL--------LFPLKSEFVILRDEGGNKTYT------------AYVDLEKDFAAEVVHPG

          IALM---QS---------------------------------------YRFSV---------AWPRPE------------------------------------------WD--LPALRGSRETAFAFAEYAEAVAR---TLN--EPWCSAFLGH----------TGEHAP-AALRAAHHLLLGHG---------------------------------------LAVEAL-AAGA-RRV------------------IVLN

                                                                                       SDL--------------------TYAYL--LFEGDGYKFSNEP---GDILISAIRKYLSF-TTKVY-------DK--------------------------NC---SKLKVTSVRSVENIIKFLQNA---------------PVK-LLG--NKK---------------QY---------------------------------KQLR--------PSN

                                               VLKT-----------MILEVEDKMVPVMFNR---------IH------------TL-----RK----------------PPKDEQELRQIFLDEG----I---DAA---A------GFAVDSMVRRFDKQF--------------------------------PAV---VVNN

                                                                KILDSCWRKLMSIKYTAQDVFQ-IDEN-PPD-------------------QS-KSQMMIDEW-ER---PTVGVLLQLLVQAE-----------------------------------------------------------------------------------------------AADFVALDFLN

  IL---GMP--------------------------------IP-------------LNGKDPAYSYRRFIQMYSDMEVPKSHFEKIID-FDTD--TA---------------DLKELAEKFKAVYK-----------------AMNGEEFPQE--------TMV--FG---YLI---NMGLTLAEVKA------------------------------------------------------------------IP-----------VKDGTM----FSR

                            PACK--------------------------GRELD--DIVGNAESIAA--------------------------VAATLKNLQ----QGMN--V--VKANGTVGSVIADLVERALEDGVIK--LPS-DFGKVEGTA-IPCVAAAMALD

                                                       TNRL------GVGLEVVKLLLGEGA--KVA---MFVRH--DVSSEADWTLVMAAQRR------VN----IL--EDFSRLLKI--------------------------NTESVFIGCQQGIAA---GSI--IN-----MASVAASC--MMQ----------SLKE---------------IAQL----------------LFL------------------------------------ASD--ES-VMSG

                                                     RHN-----------------------------DVVPTQGV-----QYFLDR--FYR--------------------DVKDAYDMAKLLCDKYYMA-SPD-----------------------------VSHLYHMLFELFKNAMTVES-----------------------------------------------------------STAPTP

                                                               PT----------IG--NA------------MVRVLLKRYLEE---KP-------IVI--L----------PVRAITKTLRD--NGIPAT-------AGTYNYVMFKTLHFSKIEGYPL-KA------GF-IHV--MCL

                                                             GNHEAVVKEAGDACFAKYSKN---------AG----------------EKKCYRDIDHYMRLINYVVGGT-GPV--------------------GSREV--PGSAYIAAFTFTRDRL--FSALDYVI

                                                                SGNAEAIAEKISKAIGNA-------V-KA--DWEDLGTLE--DF--------------V--------------------------------DQDTYSET---IFHIYEKAKAGK-VVGQ-VGL-VI--DE

                                                                                                                                                                   PREIVSELDQHII------AKRAVAIALRNRWRRM---------------------------IRDLTDSAMKLVRQQ------AKNR--LINIAF-KI--------------------RLH--VMERLMDKISFSASDMNG

                                                                 VLV---------------GRGALGS--------------------RCV--------SVDVKMTDSFTEQADQVTAEVGKLLG-----IL---CVA---------GGWA---------LMWKQSIWTSTISSHHLK-------------------------------------------------GYGMAK

                                                                    TLGKGINVSIAL-------------------------------------------------------------FV-FVY-VEGE------------------------------ETA--INF----PGPDVTDMDVNHFLRRYKMT------------KV--CVVIFV-----LLERIYEGP----SVVSY-----DIVATREGVWLIRFIK--------------AKF

LNEETGKELVREAIRNG-----------------HFPDFSL------------EQL-VLQGEYNLL------------------------EAE--ERFK---------------ENIRKVNKLAPIKHNVD--IPHIVLAWYLARPEIDILIPG----------------------------KRADQLIDNIKTADVTLSQEDISFIDKLFA

                                                       SFVSG-------------------------GAREVSP--TATC----------------RDLDYYLRLITYVAGDVTPIEE-IG----------------GVREM--PIEAIAEGVRAMKSVA---------------------------------------------------------------TSLL-GADAAEASYF-------------------LIG

                                                                  LESWLNKATNPSEGPQ-------LA--------------------------HKIQS-----------------------------------------------------------------------------QEWEALQALTVLEAC---KN------CGRRFHNEVGKFLNELIK---------------V-----------------------PKYLGDRVS-EKVK--------YS

           LSERKVYEC-QFGI-------------RI--------------------TYVNYTFLYNFW-------------------------------------------------TNVKSILPSPKKLIALTIKQTAEVVGHTPSIS---Y------------------------------------------DKNFLDVVSKTT------------FD

                                                                                                                                      VVSIAKKYTGRGLSDLIQE-QGLIRAVEKFE------YKRR--------KFSTYATWWIRQAIAIQARVET-NKLS------RTARQ

                                                                                                                               TITA--ITTL---DAERR-----FLGFDG--------------------------------GHAKQRIQEDISGERIWVELKKILVG-------------NHVNHLIHLIYDLDV---------------AP----YIGL---PKP----------------------DVT--LFIV

STEHMKESTLEAIGYICQDI--------------------MQVEACP------------IM-----TIEAMKSD---CD------------------Q----------------YLVPILTQTLTKQD-------W-----------------------------------------------------------------NPCKAAGVCLMLL--AT--CCE------IVPHVLPFIKEHIK---------------RY----DAMACI------------------SVVVRDTAAWTV--GRI--LP

                              RME---------------------RVIFEVLI--GGE-GATLREVLKHPTVEKA-----V-VI---DDARAYLERTE-------------VII------------------------------------TDPVARLLYTFYRLVKAHL--VM----GMQT

                                                                   GR--SIRG-----------------------------------------------SL------SRAERREVENVVVTALA-KYYSL--FD---KPVSPLLT---------------AG--MA-------GIWHN-------------------------------------------------------------TFLVWINE-DHTRVISMEKGG---------------------MWNER

                                                               TGTVTANLSVALGDR---K--FDFI--------PAGLQL-------MSA--------EAL------------------------------------PEISCTDTMKVGIVLKKAGLAIL---GF----VLNRYPEDPREGTLE-GI-P---KYK

 SGRYLQQELPVRIA----------------------------------------------------HRIKGFRSLP--------VVTAELR---------VRYFLKTL--------------------KIEKWVDFARRLCEHKYGNAPRV-R---------------------------PMPLDYILPELLKNAMTMHLD----------------------------------------------------------------DVV----SDRGG---AHKDL

                                                                        YGIAQSCF-ATLA----YVYE---DVKEEHFKSLY-------------VHS--AFAPAFNTAMEISVYSLIELTN-------------------TKY-MA----------HYNVMGLAKAALESA----------VRYLAVDL----------KHHIR--VNKW-GNAG--------------MYLSGE--FVD

                                                                        TLKNVYSEIRL--------------GCVRAGIHGLLY-QR--CEVF--GL-QGP---ESREHFAGLCKLLESAGI--AYTVN--QRL-VRGLD-YY----------------NR---TVF---EWVT-----------------------QGT----------GGRY------DG------------------LV------VQAV

                                                NA-----SFVSG-------------------------ENRE-----TATC----------------RDLDYYLRLVTYVSGDVTPIE-EIG----------------GVREM---ISAVAEGVKCMKSVA-----------------------------------------------------------------SLLSGDSAEAG---------YFD---------VVG

                                                               GSGKSAVASEVAHQLHA--AF----L-FLHPN---RKPWLQA--ND---IVCSA------------------------------------------------LKKHYRDLLREGN--LS----F---IYLKGD-----DVIESRLKARK-------------------------------------------------------HF-------LVT

           VPR--------------------------EK--------------------IN------------------------------------------------------------------DARILEKAAQELALITG-QKPA-------TRAK----------------------------IGLR-VTLRRDR-WIFLEKLLNVA------------RI--F--G--LN------PN-----REQLI--VDAL---------AVVTTAE--------------EARA-------PFR

ST--VTENDIRVEESPEA---------------------AIYIGG---GYRR-------------LTCYLKASAACRAAK-QDCT----------------------------DDL---VV-------------------------------TQEDAASLRVFTEAMTSAP-------AR---TP--VNSWLGNIIMLHGLSAFSL--HS------Y---SPGEI---PLRVWRHRARSVRARLL------------GK----YLFNWK-------LTPIP-------------VA-------SGGD

                                                                       RRILDRDHE---EV---LFPLL-ALRPETVMYPM-LW----YQ---F---AHTI--HAEAEEQVERAVEIYKEFFNIPYLITR-RPPWDK-----PG-------------------SE--TV--AFDTLASVAIH--LP--PDV--------------------------CR------------RVEIGPRDAAVISRRDTGEKVTAD--------LQGI-----KD-LEN-----LR

                                       TLD-----------AKFNVLHWHIVD--YQS--ITFP-----------------------------------KGSYS--WGKGQK-----TTYSFLTTFFKEISEVFP-QFIHL---GGDEVE--------FKCWE-SNPIQ-DFKKLESFYIQKVLDATI------------------------------SIVW---VEVWKDSAYPEELSRVT-------------------------------------------------SGFP