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HHKEIDELTIKEYGVDSRILERAGISVVLAEEELGNLSDYRFLVLCGGGNNGGDGFVVARNLLGVVKDVLVVFLGKKKTPDCEYNYGLYKKFGGKVVEQFEPSILNEFDVVVDAIFGTGLRGEITGEYAEIINLVNKSGKVVVSVDVPSGIDSNTGKVLRTAVKADLTVTFGVPKIGHILFPGRDLTGKLKVANIGHPVHLINSINRYVITREVRSLLPERPRDSHKGTYGKVLIIAGSRLYSGAPVLSGGSLKVGTGLVKLAVPFPQNLIATSRFPELISVPIDTEKGFFSLQNLQECLELSKDVDVVAIGPGLGNNEHVREFVNEFLKTLEKPAVIDADAINVLDTSVLKERKSPAVLTPHPGEARLVKKTVGDVKYNYELAEEFAKENDCVLVLKSATTIVTDGEKTLFNITGNTGLSKGGSGDVLTGIAGFIAQGLSPLEASTVSVYLHGFAAELFEQDERGLTASELLRLIPEAIRRLK

                                                                                                                                                                                                                     MKFIIEKR-------RRPLVHNITN----FVVMNTTAALLALGA-SPVMA-------------------------------AEEELEEMIRLADAVVINI-GTLDSGWRRSMVKATEIANKPIVLDPV---VSLLSRG-----VDVLKGNFGESALLGE------EAKKLTMNAAREFNTTVAVTGAVDYVSDGRRTFAVYNGHELLGRTGTGCMVAATGAFVA-VTEPLKATTSALVTFGIAAEKAEAK--YPFHVKLYDWLYRINENV

                                                                                                                                                                                                                 SM-DAQSAAKC---------RHPLVHSIT---NNVVTNFTAGLLALGA-SPVMA-------------------------------AKEEVADMAKIAGALVLN--GTLSKESVEAMIIAGKSANVPVILDPV---SARIREV----RLAAIRGNAAEAHTVGTD--AGGGIIRLAQQAAQKLNTVIAITGEVDVIADTSHVYTLHNGHKLLTKTGAGSLLTSVGAFCAVEENPLFAAIAAISSYGVAAQLAQTA--GPFQIELLNKLSTVTEQD

                                                                                                                                                                                                                                       MVLTVTLNPA--GKGINVSALSKLGV-PSVATGFVGLVEELRKISKLITTNFVYV-DV--VNHFLRRYKMTLSKVDCVVISGSIP---VNEGICNELVRLARVFVFVEQT--RLLIYEG--PE---NVVKPDLN--SFLGVDLKTD--YVKLAEKLAE-KSQVSVVSYKNDIVATREGVWLIRS-IDT-HLLGAGDAYVAMVYYFIKGANFLEMAKFGFASALAATRRK----------EKYMPDLAIK

                                                                                                                                                                                                                                      RVALTIAGS--DSGGVQADLVFFR-FGVYGTSALV-----------------------HLLPPEVVYAQIESVAPLHAAKTGA-LG----DAAIVEAVAEAVVRPLVVDPVM--ALKERLFP-L--DLVTPNRLEAEALLGRPIR---EAEEAAKALLALGPKAVLLKGAVDLLATRGGVLRFSAPRVH--THGTGCTLSAIAALLAKGRPLAEAVAEAKAYLT-R---KPS-----GPLD-HWA

                                                                                                                                                                                                                                     AGSLVVLGSI-NGANQAVAAG----SGA-NIAFIACTGVRQQLATD--NIDITPVS--ANALSPALVEAQRERIANASALLMQ---ES---PLESVMAAAKIAHTIVALNPA--RELPDELLAL----DIITPNETEEKLTGI---RVENAAKAAQVLHEKGIRTVLITLGGVWASVNGEGQRVPGFR-A-DTIAAGDTFNGLITALLEEKP----LPEAIRFAHAAI--------VTR-PSVPW--EEIDAFLD

                                                                                                                                                                                                                                    QRINALTIAG---TDAGIQADLTFSA-LGAYGCSVI-----------------TA-----RI-PDFVAAQLDSVFVRIDTTKIG--MLAETDIVEAVAERLQRHHVRVVLDTV----LRVRLLP---QVSLITPNLPEAALLDAPHAR--EMLAQGRALLAMGCEAVLMKG--DWLFTREGEQRF--RV----THGTGCTLSALAALRPRHRSWGETVNEAKAWL-SA---A-------GPVH-HFHA

                                                                                                                                                                                                                                     LKNILAIQS-----AGNSAAE-PRR-LGANVWPLNTVQF---------------VP------PSHLTEIV-I-LHTCDAVLSGY--LGSAEQGEHILGIVRQVKAKYFCDPV---FHGLPAS------DIIAPNLVEEILCEHA---VNNAVLAARELIAQGPQIVLVKHFE-LLVTADEAWHISRPLVD-QPVGVGDVTSGLLVKLLQGA---EALEHVTAAVY-E---V---AQ--ELQV--AA-DR-KPEH

                                                                                                                                                                                                                                     HHKVVTFGEI---YGGANVAAFLAQ--GLDAYFVTKLGAAGHLR--KFGVKTDIARGGAISAKREDFD-WEKILDGARWFHFSGITPLGKELPLILEDALKVANVTVSCDL------VIPFE------DVLIANEEDEKVLG-----S---AKIAEEVTRKYNFTVGITLRSV-VFE--GQPHFSNRY----RVGAGDSFAGLIYGSL--G-----SQKKAEFAAAA--------HTIPFVV------IE-KLAS

                                                                                                                                                                                                                                       LEVVTAGEPL--GGVNVAVALAR-LGVKVGFVGRVGVEERLRA--EGVDLTHFR--AGSALAPGAFD-PDYLEGVRFLHLS-IT-LSPEARAFSLWAMEEAKVRVSLDVN----FLERALPG---VDLLFLSEE-----LFG------RVEEALRALS--APEVVLKRGGAWAFVDGRRVEGSAFEA---PVGAGDAFAAYLAGAVWGL---V---ERLRLANAS-AS-------RGDHEGAP------VLL

                                                                                                                                                                                                                                     ECRVLSIQS-----VGNRAATPLQV-LGFEVDAVNSVQF--------------------QVLNSDLQ-LY----NQYDYVLTGY--TRDKSFLAMVVDIVQELKLVYVCDPV---LVYREKVP--VA-DIITPNQFEELLTGRKIH----ALEVMDMLHSMGPDTVVITSLMALGSQRVTQRIRMEMHKV-VFVGTGDLFAALLAWTHK-------LKVACEKTVSAMHHQ----KP---LR--S--KD-SPEI

                                                                                                                                                                                                                                      PMVFAIAL-----NSVRVVQK----LLRSAGYMGAIGLKELC----KEGLATRFMVAACG-FRLP-DW-TTFASGALIFYAT---YTLTATPKNAFEVAGYAHAIFTLNLS---CVMQSLLLHT--NILFGNEEEFAHLAK------TAAVEVCTGAL-RLKLVVMTRGHNPVIAAVVVHEVGVPV-----TNGAGDAFVGFLYALSQGKT-VKQCIMCGNAC------------------DV----LPC

                                                                                                                                                                                                                                  VR--ILFGMGNP-----GSTQNSIVAQWMI--AATFFGCIG----LKRKEAHVDAHYY----NCYKKEHLDLNWMLVEKARVCYIAGFFLT--VSPESVLKVAHHASRIFTLNLS---SLM----PYV---DILFGAATFA---QGF--ETKDIAKKTQAL--PKQRIVIFTQDDTIMATESEVTAFAVDQ--IITNGAGDAFVGFLSQLVSDKP-LTECIRAGHYA----IRR--------CT--FP--PDFH

                                                                                                                                                                                                                                      KKIAIFGAT---GQTGLTTLQAVQAGY-EVTVLVRD--SSRLPSEGPRPAVVVG-----DVL--QAADVDKTVAGQDAVIVL--LGTTTVMSEGARNIVAAMKVDKVVACT--HIRMHKVLRESGLKYVAVMPPH----------------------------------YTVTL------------PS-VISKHDLGHFMLRCL-----TTDE--YD-----PSH--------QY

                                                                                                                                                                                                                                    QKKTIAVVNA-TGR---AASLIVAAA-VGHHVRAQVHSLKAEELQA--IPNVTLFQGP-----LLNNVPLMDTLFEGAHLAFIN--TTSQGDEIAIGKDLADAAKQHYIYS---SMPKVENYVRQLGLPSTFVYAGI---------DIPL------------------------------------------LDAEDVGPALLQ-FK----DGP----IAL-----FET------AF

                                                                                                                                                                                                                  YEKALKVEAS----------------------GGQVGIMALLG-VYGIPVIAHVPQL----QASLFLDIYVPT--DDY-YV---WIERFEEIAKRSELAIISG--PLHGKPIKLVREHLKILNIRAHLEF--AFEILLKHF------YSVGLNASVV--MGEKAE--IAVIEGLLKLIK-GVKRIHFHTYYYLALTRYQLTFIPTK-------GIGDTISSAFVSEFSLH

TL-TYS-GNA--------GVVATAEIAMLLLGSAR-------------------------------------------------------------------------------------------------------------------------------------------------------------------------RT---------PL------------DNKTLGIYGF---GSIGQALAKRAQGFDMDIDYFDT--HRAS-SSDSYQATFHDS-----------LDSLLSVS----QFFSLNAPSTP-ETRYFFNATIK--QGAIVVNTARGDLVDNELVVAALAYAGFDV------AGEP---------------YYDLPTFLFPHI-----------------ATQAR------------------------------------------EDM

                                  ALIPNVKGVLLAYN----GQAGIMANLLGG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VYRIPTIVHVPQN----QAELFVDIYVPV----DYYM---FREGFEEITRNVELAIISG--VLYKDVLDRVESHLNILNVKSHFEFA---LVEL--LPKF---TSVGLNEVESI---ME--LAVSVIDAMNVLMDTGIERIHFHTYYYLALTQRQLAFVPTKIVA--TVGIGDTISSAFVSEFGMR

RS-CFC------VFNA-SNTRSVAELVIGELLLLREARGKKLGIIGY----GHIGTQLGILAES-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LGMYVYFYDIENK--LPL----GNATQVQ-------------HLSDLLNMSDVVSLH--VPENPSTKNMMGAEISLMGSLLINASR-GTVVDIPALCDALAGAAIDV-----FPTEPATNS------PFT---CEFDVLLTPIST-----------------QEAQ-----------------------------------------ENIG

                                                                                                                                                                                                                                    KKSRVLIVGGT--G--IGKRIVASISLGH-PTYVLFREVKVQMLLYFQLGAKLIEAS-------LDDHQRLVDALKQVDVVISA--LAGLSHHILEQLKLVEAIKIKRFLP--SE-DKRRRAIEAASIPYTYVSSN-----------------------------------------------------IW-VDEDDVGTYTIKI------DDPQ

                                                                                                                                                                                                                                     RSRILLIGAT--G--IGRHVAASLDLGH-PTFLLVRESLLESFKA--SGANIVHGS-------IDDHASLVEAVKNVDVVIST--VGSL--QIESQVNIIKAIKKRFFPSE----VKVRRAIEAEGIPYTYVSSN-----------------------------------------------------AG-VKEEDIGTFTIAV------DDPR------YPDV

                                                                                                                                                                                                                      LRGFDF--------KDSRVLIVG-----GGLGCAASYLASAGVGNLTLLDF-DT-PKVESARDTITPVNAL---------DDAELAALIAEHDLVLD-CTDNV--AVRNQLNAGCFAAKVPLVSGA-----YRCL--------------------LF----------------------------------------------VM-PLIGVIGSLQAEAIKML-AGYKP----------MYDAMTC-----------------QFR

SQPTAG--VT---------SISVAEHVVMMLSLVR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------WAR---------------------EAMHVGTVA---AGRIGLAVLRLAP--FDVHLHYTD-HRLP---SVEKELNLTWHA---------TREDMYPVC----DVVTLN-CPLHPETEHMINETLKFKRGAYIVNTARGKLCDRDAVARARLAGYAGD---V--WFPQP-------------WRT-MPNGMTPHI------------------LTAQ------------------------------------------ARY

                                                                                                                                                                                                                               NV---FKNTILIASGF--ARRMFAGLAYLST-NGFHVFRYD-------------------SLHEF--TGKNSLCTVYH--TQNIGLIAAS--L----SARVAYEVISDLELSFLITAVGVVN-TLDKVANTSVPLIAFTANKQEEVY------------MLAH----GHCKLYSLL---------------------GSLGNF-QSVTKAAIA--DGGSLE----IDVDF-------------------IE

QQVG-------ITNVP--SPNAIAEHAAIQARVLR---------------------------------------------------------------------------------------------------------------------------------------------------------------------------EKM-------IG-----------RDQVVGVVGT---GHIGQVFMIMEG-FGAKVIAYDIFKN-PELEK------YYVD----------SLDDLYKQA----DVISLHV-PDVPANVHMINKSIAEMKVVIVNCSR-GRLVDTDAVIRGKIFGFVMDT----EDE---VGVFNKDWFP-ADLID---VLVTPHT-----------------TTHAV-----------------------------------------RNMV

                                                                                                                                                                                                                                      MRLLVTGG----GFIGSHFVQLLAGPADEVIVLDSL-N-RANLAPVDALRFVHG------IR--DAGLLARELRGVDAIVHF-AAEFTETNVQGTQTLLQCAVGRVVHVS---KSDLRAYHRTYGLDVRITRC-CN-------------------------AGEIYHIGGGGKI-----ELGYRPQVSF-------------------------------------------DGLA

                                                                                                                                                                                                                                      KNIIVTG-----GFIGSNFVYVYNNHDVHVTVLDKL-G-KANLEAILGVELVVG-D----IA--DAELVDKLAAKADAIVHYAAESFIHTNFIGTYTLLEAADIRFHHVS---KSDLKAWVRSFGVKATISNCS---------------------------MGETYLIGA

QT-IRN-SNV--------SPAAIAEFALTDTLYLLELGQQTVGVMGT----GHIGQVAIKLFKGFGAKVIAYDPY-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PMK-----HPDFDY---------------SLEDLFKQSDVIDLH--VPGIEQNTHIINE-AFNMPGAIVINTARPNLIDTQAMLSNLAGVGIDT-----YEYEDL----------WDELLG---VVLSPHI-----------------TETAV

                                                                                                                                                                                                                       FNSDN---------GKCAIITGA----AGIGKEIATFATAGA-SVVVSDI--NADAANH-VVDAFACRC----DITSEQELSALADFAIGKVDILVNNAGGGAYELVFSFFHLSQLVEMGVILTIT---AALVNMAFDLKNIRVNGIA-----------------------------------------------------IRR-LGQPQDINAALF---LCS-----PAA------TVSG-GG

                                                                                                                                                                                                                LYKNAIEKSVPK-----------------------GQAGIMALLG--YGVPVIVHVPQL---QANLFLDGIYVP-----DYN-FIRFRESFSEVIKNVQLAILSG---AL-YPFEIVKSNLEVLNIPVHLEFA---E-ILNVLGMF---YSVGLNEVEASIMELGAKELVDVTEAMLKLAKKGVKRIHFHTYGYYLALTYQIAFIPTKIVP-STVGIGDTISSAFIGEFSFT

QQ-LRNV----ITNV--YSPNAIAEHAAIQARILREVRDQVVGVVGT----GHIGQVFMQIME-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GFGAKVITYDIFRN-PELEK---KGY--YVD---------SLDDLYKQA---DVISLH--VPDVPANVHMINESIAKMKVVIVNVSR-GPLVDTDAVIRGLFGYAMDV-----YEG---VGIFNEDWFP-ADLIA---VLVTPKT-----------------TTHAV-------------------------------------------RNM

                                                                                                                                                                                                                                     DGKTALITG----ARGGRAFAAYVREGA-RVAIADILEAARATAAEIGPAACAIA-----DVTDQSIDRCVA---SIDILVNN--AALLFAINSGTLFMMQAVAGKIINM---AK-AVISLTQSALINVNAIAPG----------------------------------------------------FGR---RADLTGMAIF---------TPE

        AYPEV-VNKAINNTDGTGHIRAKESGFDIKGKT-VLLG-----GGASTAIGAQGAIGLKEIKLFNRRDEF-DKAL---AFAQRVNVTVTDLAFAEALASADILTNGTKVG-KPL--------LVND-ISLHLLVTECVY-------------------------NPHTKLL-------------------------------------------------------------------------------------------------------------------------------------------------------------------------QQAQQAGCKTIDGY----------------------------------GLLFPLE-FGA

                                                                                                                                                                                                                   MMS----E-------PAQPKVWLITG-----GFIGSNLLTLLK-LDQKVVGLDNF-H-QRNLDEVRWFKFIQG------DIRN-LDDCNNACAGVDYVLHQ-AALSNATNIDGFLNMLIAARQSFTYAA--KYVNELYADVFSGFSTIGLRY---------------------------------------------------------FCI-NTVQANLL---AATAG---------NIAVG---------GRT

                                                                                                                                                                                                                                 KAP-APVIVIAQEIFG-NAFMRETVWLVDQGY-AAVCPDL------------------YARQALWDMEAGVGDLEAAIRRKVGLVGYCL------GGAL-FLVAAKGYVRAVGYYG--VGLQLNKVPEVKHPALFHMGGQDPSRQLIT--------------FGANPLQVHWYEE----------------------FAR---N---TLDFLAP

                                                                                                                                                                                                                                      MRVLLATCGSRGTEPLVALAVRVRDLGADVRMCAPPDCAERLAE--VGVPHVPVGP----AIATQFDEIPAAAEGCAAVVTTG-------LLAAAIGVRSVAEIPYFYAF-----------------------PSYV--PSPYY---QPT--DL----------DAVQ----------------------GAWI-----------------------------LPD--ERPL

                                                                                                                                                                                                                                     RKIALITG-IT--GQDGSYLTFLLGKGY-EVHGLIRRS-NTQRINHIYKMKLHYA------DLTD-ASSLRRWIDVIPDEVYNLAAQ-ADVVATGALRLLEAVRTVKYYQAG---AHWVNYREAYGLFACNGIL----------------------------------------------------------NH-DYVEAMWL---ML-QQE-------VAT

                                                                                                                                                                                                           DAKI------KSENE-------------NIACFVNG---AGLAMATCIIFLNGGKPANFLDLG----------------------GGVKESQVYQAFKLLTKVEAILVNIFGG-IV-NAIIANGITKACKVPLVVRLE--TNVAQNILTNSGLPITSAV---------------------------------------------------------------DLEDAAKKAVASVT

                                                                                                                                                                                                                                    ATKSVLMLGS----GFVTRPTLVLTDSGI-KVTVACRTESAKKLSAGVQHSTPISLD-----V--NDDAALDAEVAKHDLVISLI-------PYTFHATVIKSAIKHVVTTS----YVSPAMMELDAAVMNEIGLDPG------------YAIK----------------------------------CGG----------------------------------------PAP---YKF

LH-AYE-TV-------LTPMIIAGRLSVQFARFLELLG--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GVPGV---KPGKVVILGG----GVVGTEAAKMAVGLGAQVQIFDINVRLSYLETLFGRVELLYS----------NSAEIETAVAEADLLIGA-VLVRR--APIL---VPASLQMSVIVDVAVDQGG---TLEVFGVVHYGVPN---------------------------------MGAVP----------------WTAT-----------------------------------------QALN

        IFQA--MAR-NGPCQALADYMTWEKKGTIKGVKVVYVGDG---NNVAHSLMIAGTKLGADVVVATP-GY--------DEKVIKWAEELLHDP-VKAVKDADVIYTDVW-------RRKIFRPFQVDLVKHAYMFMHCLPAHR----------GVTVISVV--------------------WDQARL-VLA

                                                                                                                                                                                                                                  EAPKALLLALHGL-QGSHILALL-GYAE-RGFLLLAFDA---------------------PRH-VALGFKEEARRVAEGLPLFLAGGSL-------FVAHLLLAGFRPRGVLAFI-GSGFPATRGEAYGGVPLLHLH-PLAREK-EAL--------------RPHYRLARFVEE----------------------TLTLARVGLFLEHWLEA

                                                                                                                                                                                                                                     MAEKVLVTGGA--GYIGSHTVELLEAGY-LPVVIDNF--LPESLRRVQRSVEFEEMD---ILDQGALQRLFKKYS--FMAVIHFAGLVNLTGTIQLLEIMKAHGVKNLVFS--------------------------------PYGKKF---EMIRDLCQ-KTWNAVLLRY-----------------DYI----DLAKGHIAL-RK---KEQC---CR--IYLGT

                                                                                                                                                                                                                                    TAPVALVTG-AA--KRLGSSIAALH-AEGYTVCLHYH-RSAADASTLAATLITVQA-----DLLFSRCSALVDACYRCDVLVNN-ASSFLFGSAIAPYFLIKAFAYSIVNMV---KLEGRSAALELAIRVNGVSP------------------------------------------------------LY--EVSDVVIF------LCSPKA---------IKVDGGY

FA--IRHPARLAAE--D--H-PTTLLDLYTKKEFGRIDGLKIGLLLKYGRTVHSLAEALTFYD----VELYLISLL-------HIVEELREKGMVVETTTLEDVIGKLDVLYV-TR-QK-----KGSYQ-----VNLL-LRIMH-PLPRV----------DEIH---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PEVDN--TKHAIY---------------------------------FRQV-----FN-------VPMALL-----------------------------------------LVL

MYVRIG----AVC----PAVEETADSTLCHILNLYRIRGETLGIIGL----GRVGQAVALRAKAFGFNVLFYDPYL--DGIER-------ALGLQRVS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TLQDLLFHS----DCVTLHCGLNE-HNHHLINFTVKQMRAFLVNTAR-GGLVDEKALAQALRGAALDV------ESEP-----------SFSQLKDAPLICTPHA-----------------SEQAS------------------------------------------IEM

                                                                                                                                                                                                                        NDL----------GKTVIITGG----RGLGAEAAQAVAAGA-RVVLADVDEEGAATARELGDAARYQHL-----DVTI-EEDWQRVV-SVDGLVNN--AGIVVEINTGVFIGMKTVIGSIVNI---SSSKVRGLSKLAAIRVNSVHPGM--------------------------------------------------------RV-EIAGAVVK---LLSDTS-YV-----ELAVDGGWT

    TIP--------HKAVNNTDGIGARMAEEEIGRVKDKNIVIYG-----GGAARAVAFELAKDN-NIIIANR----EKAE------AKEIAVKFSGLDV--DLDGVDIIINATPI--YPNIDV--EP-IVKA--LREMVVMDLIY----------------------------NPL----------------------------------------------------------------------------------------------------------------------------------------------------------------------TVLLKEAKKVN-AKTINGL------------------------------------------------------------------------------------GM-IYQGAVAFKIWGVE

                                                                                                                                                                                                                                     GLVAVITGG----SGLGLATARLVGQGA-SAVLLDLPNSGEAQAKKLGNNCVFAPAD----VTSE--KDVQLA--RVDVAVNC--AGI-DVNLMGTFNVIR-VAGVIINT---AS-GIVGMTLPIDLRVMTIAPGL------------------------------------------------------TPDPAEYAHLVQIE----NPFL

                                                                                                                                                                                                                                     TAVIKVIGVG-GGGNAVNHMAVEG------VEFICA-LK-NIAA-------RTVLQLGLG-AALEDRERISEVLEGADMVFITTG-TGTGAAP-IIAEVAKEMGILTVAVVT--GIALAESV------DSLITIP----------------------------------EK--------------TIL----KADDVLAGAVISDII-KDFDV----------TGC---ASRAREA-------------TAG

                                                                                                                                                                                                                                     KGLVAVITG----ASGGLSTARLVGQGA-TAVLLDVPNSGETEAKKLGGNCIFAPAN----VTSEEVQAALT---RIDVAVNC--AGIVINVNIGTFNVIRLVAGVIINT---AS-GIVGMTLPIAIRVVTIAPGL----------------------------------------------------FP-----EYAHLVQMIENP

VL--ARV--DTLAK----NGPIQILADYLTLEHYSSLKGLTLSWIGDG---NNILHSIMMSAAKFGMHLQAATP-GY--------DASVTKLAELLT-NDPLEAAHGGNVLITDTWIS--KK-LQ--FQGYQV-TMKTAWTFLHCLPRKP----------EVDVFSLV--------------------FPEARK-AVM

                                                                                                                                                                                                                                 SGQARFSVLLLHG--IRFS-SETW-TLHRLAGYRAVAIDL--LGH--------------AAA-APLAP--GSFLAAVVDLGPPVVISPSL------GMYSLPFLTASQLPGFVPVAP-ICTDAANYASVKTPALIVYGDGQTSFE------------HLKQ----LPNHRVLIMK-------------------GAGCYL---W---LL-FL--QGL

                                                                                                                                                                                                                                     RNVALITG-----GQDGSYLAFLLEKGY-EVHGIVRRS-NTGRIEHLY-MKLHYGD-----LT--DSTCLVKIINEVPTEIYNLGAQ-ADVDGVGTLRLLDAVGLVKFYQAS--AYWIVNFREAYN-LFAVNGI---------------------------------------------------------FNH-DYVEAMWL------LQN

    MRH---FASE----NAPTQAVIDIYTNKHFNTIDGLVFALLGDKYA--RTVNSLLRILTFRPKLVYLISPLL----------EILDELNPVKE-VENFEVINEVDVLYVTRI-QK-----EKIKGSYIVSLANKMSIILHPLPR-VN----------EI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DRKVDK--TTKAKY---------------------------------FEQAS---------------------------------------------------GVPVMSI-LTKIY

                                                                                                                                                                                                                                     AGKVALTTG----RGIGRGIAIELGRRGASVVVNYGSS-SKAAEEVAELGVAIQAD----ISKPSEVVALFDK--GGLDFVMSNSGMVFNLNTRGQFFVAQQGLCRIILTS---KVEGFAFAVDCGVTVNCIAPG-FDE------------------------------PL---------------------DIGRAVSAL--CQE------ES-------VIKL

                                                                                                                                                                                                                                    PSVKIGIIGAG--SAVFSLRLVDLCKTSGSTVTLMDIEERLDAILTIAKKFEKTM--------------NLDDVIIDADFVINTAM---NYNQLKYFVDIARKIEKAWYLQAANPI-EGTLVTRTVPIKAVGF------------------------------------GHY-----------VME

                                       MRVLVTGGS---GYIGSHTCVQLLQNGHDVIILDNLCNS--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------R---VLPVIERGKHPTFVEG---DIRNLMTEILHDHA---IDTVIHFAGLNN-NGTLRLISAMRAANVKNFIFSS--VEILTDLQKAQ-DWSIALLR-----------------------------------------------------RDYI----DLADGHVAMEKL-----NK--HIYNL---GAG

                                                                                                                                                                                                                                     SGLRALVTG---AGKGGRDTVALHASGA-KVVAVTRNSDLVSLAKECPGIEPVCVD-----GDWDATEAL-GI-GPVDLLVNN--AALSFSVNLRSVFQ--QMVASIVNV---SSTKMTMLTKAMEIRVNSVNPT---------ARK----------------------------------------LRKF----DVVNSILF------SDRS

   VGLPE--------INI-IR------RNET----MNHV--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KQTSLHLFGLLSSHIHHLYALLLAAKEGVKRVYIHGFLAYIKELQEKIKVGEIATLSGRY--SMEKAYRAMVYTIQD-NDAIIFYN-FRPDRAIQISNTFTN-PKHLFFVCLT--HFSET-------AG--YVAFKP--------------------------KKIKLRDG---------------GI-------LGDLAPTML-LG-----------------GK

                                                                                                                                                                                                                         PL----------DGRVVLVTG----GGLGRAYAAFAERGA-LVVVNDLSSAADKVVEEIRKAVANYD------SVE-AGEKLVKTALGRIDVVVNNAGIIQRVHLRGSFQVTRAAW-GRII----TALLGL--TL-EG-IHCNTIA----------------------------------------------------------NA-YVAPLVLW-HE-----SCE------FE--VGA

                                                                                                                                                                                                                                     GEAVLITGG----ASGGRALVRFVAEGA-KVAVLDKAERLAELETDHGDNVLGIVGD----VR--SLEDQKQAASKIDTLIPN--AGIVFHINVKGYIH--VK-GNVIFTIS---AKIVGLVRELAVRVNGVGS-------------------------------------------------GGINIGR-------TGAYVF----ATR----GDA

                                                                                                                                                                                                                 YDA-GPQSAS----------GKVALVTG-AG--RGIGREMAMELGRRGCKVIVNYAN-STESAEEVVAKAACVKA------NVGV-VEDIVRMFEKLDIVCSN--SGVVFTINRGQFFVA-REAYRLILM---GSSAIETFARCMDMTVNVVAPGG--------------------------------------------------------DIARVVCFLASN--------GW-------IGID--GGA

                                       KRLMVMAGGTGHVFPGLAVAHHLMAQGWQVRWLGT-DRM---------LVPKHGIEIDFIQARAIMKKPDVVLGMGG------------GPGGLAAWSLGIPVVLHEQ-TNK----------WLIATKVMQA-FPGAFPN----------AEVVGN---------------------------AGR--EGPVRVLVVGGA----RILNQTMVAAKLGSVTIWHQSGKGSQQSVEQAYAQHKVTEF-------------DMAAAYAWADVVVCR---------GALTVSEIAAAGLPALFVPF--QQYNA--PLAG--AAKIIEQ--------------------------------------------------------------LSVAV-TL-GW-SR--TL

                                                                                                                                                                                                                                     GKQLTILGS----TGSGCSTLDVVRHNHFRVVALVAGKV-VEQC---LEFSPYAVLSG----QQ-ACD-AAL--EDVDQV-AA--IVGA-AGLLPTL-AAIRAGKTILLA--NKESLCGRLFDAVKAQLLPVDSEN-GLEYI----------------LFN--------SVIHS-------LAQLGE-----PDRTPIA---HT-----AWPFTDIAALNL---EK--------REP--VLSVDANAREV

      SVFDVV--FVG-LDNTTAAAGVALVKAAGGSVK----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GKKAVVLAGT---GPVGMRSAALLAGEGAEVVLCGRKDKAQAAADSVNNVTAAETA---------DDASRAEAVKGAHFVFTA--GAI----LEL---LPQAAWIEIVADYN-AQPP---GI---YKRAFGAL--------------------------------GIGGLKL--------------ACI------------------------------------------GV---------DAEEI

                                                                                                                                                                                                                                     SHMRVLVCG----GYIGSHFVALLRDTNHSVVIVDSLKS-DHVE---VRYAALEVGD----RNEDFLNGVFTRHGPI-DAVVHMCAFNNVVGILRLLQAMLLHKCDKIIFS---A-MIRDCAEAYG-IKGICLR----------------------------------YF-----------------RDY-VHV-DLASAHIALD------EKL

                                       AKLLITG-----GFLGSNLASFALSQGIDLIVFD--NLSRKGATDNLHWLSSLG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NFEFVHGD-----IR--NKNDVTRLITKYPDSCFHLAGQ-DFEIVGGTLNLLEAVYNCNIIYSS---ADQLDYARIFG-LNTVVFR--------------------------------HSSM------------------DV-LHAISLYFT--ALA-----NVSKI

                                                                                                                                                                                                                       MELF---------AGRRVLVTGA----KGIGRGTVALHATGA-RVVAVSRTQDLDSLVRECPGIEPVCVD-----LGDWTERALGSV--GPVDLLVNNAAVASFEVNRAVIQVS-QIVAGAIVNVS--SLDMLVMALEL-IRVNAVNPTATW------------------------TGSTLPVEGG

                                                                                                                                                                                                                         RW-----------EGCTALVTG---RGIGYGIVELASL-GA-SVYTCSRNELNDCLTQWRGFKVEASVC--DL-RQELMNTVANHFH----NILVNNAGNFEAAYHLSVLAHPFLSERGNVVFI----TKFEWAKD---NIRVNGV----------NK------------------------CA--------------LRR-MGEPKELAAMVAFCFP-----AAS-------IYVDGG--MAN

                                                                                                                                                                                                                                     KKVALVTGA----QGIGKAIARLVKDGF-AVAIADYDATAKAVASEINHAVAVKV------DVSD-RDQVFAAVEGFDVIVNN-AGVAVYNINVKGVIWG-QAAVKIINA---CSSKVRGLTQTADLTVNGYCPGRI--------------------------------------------------LGR--DVAACVSYLASP-----------DS------LL-GMVF

                                                                                                                                                                                                                                      MRVLITGCGSRDTEPLVALARLRELGA-DARMCLPPDYVERCAEV--GVPMVPVGR-PP--VAEWFDKVPAAIEGCDAVVTTG-------LLPAAVAVRSMAEIPYRYTV-----------------------PDHLPS-QS-RPTDL-----G-----------TVQ--------------------------GAW-SL---SAAL--DTA

                                                                                                                                                                                                                                     EGKIALVTG----SRGGRAIATLAARGA-KVIGTATSEGAQAISDYLGANGKGLMLN----VTDPSIESV-LE--EVDILVNN--A--IIETNSSVFRLSKAVMGRIITIGS---KGLIGFSKSLVITVNVVAPGF------------AQ-----------------------------------------LGGAQIANAVAF---------DE------LHV-NG

                                                                                                                                                                                                                                     KLRIGVVGL----GGIAQKWLVLAAASWTLQGAWSRAKALPICES--WRIPYA---------------SLSSLAASCDAVFVH--SSTA--SHFDVVSTLLNAGVHVCVDK-PLAE-AERLVELAKLTLMVGF----YLH------VDTALW

                                                                                                                                                                                                                                      KQFAVIGL----GRFGGSIVELHR-MGHEVLAVDINEEKVNAY---SYATHAVIAN----ATEEELLSL--GIRNFEYVIVA-IGANIQASTLTTLLLKELDIPNIWVKA---H-VLEKIG------DRIIHP----------------------------------DMGVK-----------QS

                                                                                                                                                                                                                               TG--LDGKRILVSGI----ITIAFHIARVAQEQGAQLVLTGFDRLIQRITDRL-KAPLLEL------DVQNHLASLAGRVTNKLDGVVHSIGFGIHISAYSYASMAKALLGSIVGMD---KLESRFVAREAGVRSNLVAA---------------------------------------------------------PIRAKTVCALLS------DWLPA------IY-ADG

                                                                                                                                                                                                                                    TDRVVLITGG----SGLGRATARLAAEGA-KLSLVDVSSGLEASKAAVLEVLTTVA------DVSDQVEAYVTA-GRIDGFFNN--AGIVSINLRGVFLGLEKVLGMVVNTA---KVVGL--RNSEYIRINAIAP----------------------------------------------------PSYGEA---EIAAVVAFLSD---------DA

                                                                                                                                                                                                                                 RAK-RYPITLIHGCCL-TW---GWDYFLRKGY-STYVIDQ------------------SGRWL---PNPTVANLSKLAIKLGTVLLSHSQ-------IYPFQTAAMNPITAIVSVEP-ECPKPEDVKPLTSIPVLVVF-RLKACHA---------IDAL----NAAGGKGQLM--------------ALG----VHGMMV--ALI-WI------GRN

                                                                                                                                                                                                                                    NT--RVALVTGAIGFAIVRDLC---RQF--AGDVVLTGQAVKQLQA--EGLSPRFHQL---DIIRALCDFLRKEYG-GL-DVLVNNAAN-MGTRNVCTELLPLIKPQGRVVNV--V---Y-KLEQR-DKILLNAC-----------------------------------------------------------GAETPVYLALL-----PSDAE------TDK

           PILAVNAGVNQKVARALEWLD---VQPEDRVLDLFCG-------GNFTLPLATQAASVVGVEGV----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PALVEKGQQNARGLVTFYHEN----LEEDVTKQ--PWAKNGFDKVLLD-PARA--GAAGV-QQIIKLEPIRIVYVS--TLRDSEALLKAG------------------------------------YTIARLA

                                                                                                                                                                                                                                   IRGVKVDKHS-GGVGDTTTLVLGLVASVGVPVAKMS-GRGTIDKL-----IAIIGQ--VN---IASSIMSKKIAA--GADAIVLD--VKTM-EARL-ARVMVDIGGRRTMAVIS-------------------------------------------------------------------------------HDLTELCLTLGHMVYLAE-----PSLDEARRLLEEAIRS---------AIA

                                                                                                                                                                                                                                     SPVVVVTGA----RGIGKAIASLGKAGC--KVLVNYARSAKAAEEVSKEAITFGGD-----VSKEDVEAMMKT--GTIDVVVNNAGITIDLNLTGVFLCTQAATGRIIN---IASVIGKTAAREGAINVNVVCPGF-----------------------------------------------------------NVAGLVEFALS-----PAA---QA---TID--GGI

                                                                                                                                                                                                                         YK----------GKVVVITG-----TGLGKSMAIRFATEKAKVVVNYRSK-EDEANSVLEEAIAVKG------DV-TVESDVINLVQKLDVMINN-AGLA-NKVIDTNLTGAFREAITVINM---SSSKMKLMTETLAIRVNNIGPGA----------------------------------IP-------------MGY-------EIAAVAAW--SS--------EA

                                                                                                                                                                                                                RVFY-DKDCDLS---------GKKVAIIGY----GSQGHAHANLKDSGV-DVTVGLRSATVAKAEA--HGLKVA---------------DVKTAVAAADVVMIL--TPDE--FQGRLYKIE--LKATLAFAH--GFSQV--VP-RADLDVIMIA-----------------------------------------------------------APG----------------NAKNVAL-AGGR-TG

                                                                                                                                                                                                                                     KQRVFIAGH----GMVGSAIRQLEQRGDVELVLRTRD-----------------ELN---LLDSRAVHDFFASER---DQVYLAAAKVNMMIESNIIHAAHQNDVNKLLFLG--KGLCESYNRQYGRDYRSVMPTN----------------------------------------------------EF-LHVDDMAAASIH------ELAHE-------HIN

LG-----AELP--AQSDSSQNLAGYRAVIDAYEFAAFP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TAT--VPPARVLVFGV----GVAGLQAITAKRL--GAVVATDVAATKEQVES--LGGKFITVD-ATA--RKKQAEAVLKELVKTDIAITT--ALI--PAPVL---ITEEVTSVIIDLA-VEAGG---PL--KHVKIVGHTN---------------------------------VPS-----------------------------------------------------VAADASPL----AK

                                                                                                                                                                                                                                        KVAVLGASGGQPLSLLLK--SPL-V-SRLTLYTPGVAADLSHIETRATVKGYL---------GPEQLPDCLK--GCDVVVIPAGVTNTIVATLTAACAQHCPDAMICIISNP-ITAEVFKGV-Y-KIFGVTGH----AG----TIIPL-----------------------------------------SMAYAGARFVLVDAM--NG---------VV

                                                                                                                                                                                                                                    ADTRIGVTIKYDDNSVVRKAIEDAKAAPDVQLLMNDS-----------------------QNDQSKQNDQIDVLLAKVKALAIN-------VDPAAAGTVIEKARVPVVFFNK---EPSRKALDSYD-KAYYVGTDS-------KE----------------------------------------------------------------------------------SGIIQG

                                                                                                                                                                                                                                    TVPVALVTG-----KRLGRSIAEGLHAEGYAVCLHYH-RSAAEANALSATLITVQA-----DLLFTRCAELVAACYRCDVLVNN-ASSFLFGSAIAPYFLIKAFAYSIINMV---KLEGRSAALELAIRVNGVGP------------------------------------------------------LY----AEVSDVVIF---LCSSKA------------VKVDGG

                                                                                                                                                                                                                                     GKRVVLAFGT---RPEAAPVYALRGIPLK-LVLLTGQHQLRQALSLFGIQEDRNLDVQ----AARILPQAARALKEGADYVLVHGDT---LT--FA-WAAFLEGIPVGHVEA--RRDV------LT--DLDFAPLAKANLLK---------------GKR-----GILV----------------------GQTG-GVYRVVK--GLLE-PEEL

                                                                                                                                                                                                                                     TNKNVIFVAAL--GGIGLDTSELVKRNLKNFVILDRVEN-PTALAELKA-ITFHTYD----VTVP-SKK-LKIFDTVDILING--AGIIAINFTGLVNTTTAIGGIIANIC---KVVSFSLAKLAGVTAYSINP-----------------------------------------------------GIT--QCGQNFVK---AIEA---NKNG

                                                                                                                                                                                                                     VKEAWGF--------HGIVVSILDD--NDNRHGTRCAGVAAAYNARIGGVRM-----------------------GEVTDAVEARSGLNPNHIHIYSAS--WGPE---GP--EEAFFRGVSIFVWASG--DGYNS-IY------TLSISS-SEA-CS--------------------ST--LATT-------------------EKQ---HTTSASAPAAGIIALTL-VVQTS

                                                                                                                                                                                                                  PEDELLE----------QTKAKITVVGCG-GANNTITRL---IE---GAKTVAINLIRTK---------ADKKILIGLGA-AKESAEEIKAAIQDSDMVFITCG--GG-TGTGSAPVVAEISGALTVAVVT--GLERKQHT------DTLVVIP----------------------------------------------------EIV-VADEVLINAVKLVELIT-FADVAV-----LIH--VMG

                                                                                                                                                                                                                                      MNLISLFS------GAGGLDLFQKAGFRIICANEYDKIWKTYESNH-SAKLIKGD------ISKIS---SDEFPKCDGIIGG--PPCSDPRGKLFYEYIRKQKKFFLAENV--M--FIQEFDNAGY-----------------------------------DVHIILLND-------------------QDR------------------NYL--PPI--PH-----------PTF

          VTETLH-KE-FPETEELVELE----LIRGIKTVADIG----TG--GAIGVSVAFSDAIVFATDVSSKA---VEIA-KNAERHGVFFVR-PFKEKFASIEMILSNPPYVFGG---LDF---FFR--YDTSGKIVLMEI--------------------------GEDQVEE--LKKI-TVFLKDS

                                                                                                                                                                                                                                      MRVLLSVCGTRDVEIGVALADRLKALGVQTRMCAPPAAEERLAE--VGVPHVPVGL----TVEMQFDAVPGAAEGCAAVVAV--GDL--AA-TGVRSVAEKLGLPFFYSV----FGY----------E-RPLLL---------QPDV-----------------DAVQ--------------------------GAWL-----SAAL--TTVAP

    YRG---TLAV----NGPTQLLADLLTQEHLPGKAEMTLVYADARNNMGNSMLEAAALTG---LDLRLVAPAC-----EA---ALVTECRNITLTEDVAKGVEGADFIYTD-V---WVR--IALLREYQV-NSKMMVKFLHCLPAF-----QTLGMAMEVTFSIV--------------------FAERMHTI

    RHP---LAT--DGNQHPTQTLLDLFTQETQGRLDNLHVAMVGDLKY-GRTVHSLTQALAKFDGNRFYFIAPDAL-------PQYILDMLIWSLHSS-EEVMAEV-DILYMTR---QKVKA--QFV--L--DLHNAKMKVLHPL----------RV-DEIA---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDVDKT---HAWYF---------------------------------QQAG--------------------------------------------------GIFARQ-ALLALVL-------------------LVL

                                                                                                                                                                                                                         SG----------GKVALVSGG----ARGGASHVAMVAEGA-KVVFGDIDEEGKAMAAELADAARYVH------DVT-QPAQWKAAVDGLHVLVNN-AGILN-RILDVNLTGVFLGI-SIINISS---TKFRGLTKSTELRVNSIHPGL-------------------------------------------------------AA-PV--SNVVY----ASDES-----AE--VV---DGGT

                                                                                                                                                                                                                                      MKLYMSVDMRIMTEEANYCIEAFNSGCTEVLVNDSMNNLMV--KLHPEADLISGD--------SMV-EG--LDDTFRGALF-LGYHAHSMELGLNAYVAGYYDVPVLMVAGAAKEA--ELI-----------------------------------------PNVTTAA----------------QTKCL-KRGRLLTEKTAL-QN----DK----------MTELAMRTSFC

                                                                                                                                                                                                                     VLDLWNI--------AGVVAAIVDD----DYHGTRCAEIAAGYNAKISGIRISG------------------IT----TEDEAASLIYGLDVNDIYSCS--WGPQGP-----KKALVKGVAIYVFASG---YTNS-IY------SITIGAISEGC-------SAV----------------MAVT------------------SGEY--SHGTSAAAPAAGVYTLLL

LV-RR-ESK----GFGERDEYIYHETLVHPMLTHPEP-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRVLIVGGG---EGATLREVL--HPTVEKAVMVDIDG-VE----FDDPRAVLVIDD--------ARAYLERT-EERYDVVIID-LTDPVPARLLYTEFYRLVKAGVMGMQ--TG-VHRTVREAF-------YKNNF--------------------------DPA-----YLEMF

PR----LGHE-RGC-AMAMCGATAYHAFDE--YPESFAGKTVVIQGA----GPLGLFGVVIARSGAENVIVIAGS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PNRLKLAEEI---GADLTLNRRE----VERRKAIMDITH-GA-DFILEATGDSR-ALLEGSELL--RR-GGFYSVAVAVPFKV-WLVLKN--ATFKGI--------------------------------WVSDT-------------------SHF-------------------------------------------VSI

                     INNS----------FWQGKRVFVTGHT---GFKGGWLSLWLQTGATVKGYSL---PT----SLFETAR--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VA---D--GMQSEIG---DIQNKLLESIREFQ----EIVFHMAATNVMGTVYLLEAIRHVGGVKAVVNIT--AVTYRSFFN--HGTAVATVR------------------------------------------------------IRP----EPLSGYLL-------TDG----------GPN---ATPV

ITAETG----ISPAFSGN-PPVTAYGVYRGKAAAKSLEGLAVSVQG-----GNVAKALCKKLNTEGAKLVVTDVN-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KAAVSAAVAGADAVAP------------NAIYGV---TCDIFAPCALG------AVNDFTIPQLKAKVIAGSA-NQLKDPRHGKYLLGIVYAPDY----------------------------------------------------------------VINAGGVINVAD-RAMKRVDGIY--IEK---IS-------SYVAADRMAEE

                                                                                                                                                                                 SV--GVARLL-------------------GFME-------KD----------ERPYAVVLG--AKVSK-IGVISLLP---RIDRLLIGFL----AKDLLGRARVYLPEDVVLDI--KTREAFARALEGARTVFWNGPMGVFDEGTLAVGQAIAALEAFTVVGGDSVAAVNRGLKER---GHVSTGG------------------------------------------------------------LEFLE------------------------GT--LP--------------------GLEVLE

                                                                                                                                                                                                                                       PVVMVHGIG-GAFNFAGIK--SYLQGWSLYAVDF-----------------------WDNGPVLSRFVQKV-L---DIVAHS----------NTLYYIKNKVANVVTLGGANRLTTGK-ALPGKILYTSIYSSMNYLS---------------------DGARNVQIH--------------------GVGHIGLLYS--LIKEGL--NGG

                                                                                                                                                                                                                                      RSALVTG-IT--GQDGAYLALLLEKGY-RVHGLVARDTRWRLRELGGDIQYEDGD-----MA--DACSVQRAVIKQPQEVYNL-AASGVVDGLGVTHLLEAIPETRFYQAS--KGHWVNYRESFGLHASSGI------------------------------------------------------RDWG-DYVEAMWL-----------QDK

                         IGSAAVELAESLHDKTVLVVGA----GEMGKTVAKS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------LVDRGVRAVLVANTYERAVELARDL--GGEAVRF---------D--ELVDHLARSDVVVSA--TAAPH---PVIHDDVREALPILIIDIA--RDVEEGVEN-IEDVEVRTID---------------------------------DLR--VI---------ENL-----EKLK---------SLHEIK-AEAYT--LINVLTSAIMELP----------YRRAAS

                                        KVLTVFGTRPEAIK-APLVHALAKDPFEAKVCVTAQH----LDQVLKLFS--IVPDYDLGLKPILAFKPDVVLVHGD--------TT--ATSLAAFYQRIPVGHVEA-----RTG--AN--LTHLAYHFSPTETSQNLLRE--NV---RIFITGN-------------------------------DPDK

LDDSEE-----PAITKSKFDYGCRESLIDGKRATDVIAGKVAVVAGY----GDVGKGCAQALRGFGARVIITEIDPIN--------------EGYEV--TTDEACQEGNIFVTTTGC------------DILGRHFEQ-AIVCNIGFDVE-----------IDVLLAVNL-------------------GC--GHSF-QV

                                                                                                                                                                                                                                      MKVTIIGAS---GRVGSATALLAKEPFMKDLVLISINKLEGLREDIYDAIYVES----------DEN--LRIID-ESDVVIITSGVN-AKIVGKYAKKIAEICDTKIFVIT-M--KALVDS-KFENQVFGLGT--IIG-------SMVPL---------------------------------------KG-EFGPAAAILV--IV-NNE------KR---LLT

    VRS--INQF-----SMPLQSFADLITEEYK--TARPKVVMTWAPLP-QAVPNSFAEWMNATDYEFVITHPYE--------LDPKFVG-NARVE-YDQMKAFEGADFIYAKNW-----------DRNWTV-GDRQMAYFMHCLPVRR----------NMI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------TDDVIE-SP-QSIV---------------------------------IPEA---------------------------------------------------NRIS--VV---RLL

                                                                                                                                                                                                                         TN---------QGKVALVTGG----ASGGLEVVKLLLGEGAKVAFSDIEAAGQQLAAELGERSMFVRH-----DVSS-EADWTLVMATLNVLVNN--GILLRL-LKINTESVFIGCGSIINM---ASSKASALTRAAAIRVNSIHPDG----------------------------------------------------RAY-RIAQLVLFLAS------DESSVM---------LHADNS

                                                                                                                                                                                                                                     ANAPIMILNLNLLADVEALCVKAAAAHGGTVDFRQ------------------------SNHEGELVDWIHEARLNHCGIVIN--PAAYT--SVAILDALNTCDGLPVVEVH---SYVSQR-------ADGVVA-----------------------------------GC----------------------GVQGYVFGVEIAALAG

                                                                                                                                                                                                                                EY-LKRLRNIGIA-ID--TTTTERIL--FWKDHRINIIDT--------------------------GHVDFTIEVERSMRVLDGAIVVF---GV-PQSETVWRQAEKYKVPRIAFA------------------------DLWLVIR--------------------RPVVMQLPIIDV-------LRMKAYTYG---KNKGVQLLLAVVDY

                                                                                                                                                                                                                                      PRVGIIMGSDSDLPVMKQAAEILEEFGIDYEITI-------------------------SAHPDRMFEYANAEERGIEVIIAG-AGGA---AHLPGMVASITHLPVIGVPVSLFSIQMP--GGV--PVATVAI--------------------------------------------------------------NAKNAGIAASILGI----------VKEYKERMKR----EV

VS-VVT----GN----AGSADAVAEFALALLAPYK-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------EKGDYGRDVE--------QG--EKVAVLGL----GEIGTRVGILAA-LGAQVRGFSRTPKE--------GPWRFTN-------------SLEEALREARAAVCA--LPLNKHTRGL---VKYQHLAVFVNVGRA--EVDRDGVLRILFIFASDV---WW-GRND--------FA---AEFF---VVATPVGN-----------------ERVW-------------------------------------------RQ

                                                                                                                                                                                                                        RWS---------GTTALVTGGS-----KGGYAIVEELAGLGARVYTCSRNEELDECLEIWRNVEGSVC--D--L---LSRTERDKLMDKLNILVNN--GVVINIIMGTNFEAAYHLSANVIFL---S--SKGAINQMSLAVNSVAPG---------EIDNFIVKT---------------------------------------GKPQEVSALIAFCF---------PAA---IIWADGG

                                                                                                                                                                                                                                   RK-DHFIVCGH----SI-AINTILQLNQRGQNVTVISNLPDIKQLEQRLDNADVIPG-D----S---NDSSVLKGIDRCRAILALSDN------DADNAFVVLSADVKTVLAVS----KIKMVH----PDIILSPQL--------------------------------FGS-EI--------DML

                                                                                                                                                                                                                                    SS-GKVIVYGGKGGSAILEFFK----KNGY-TVLNIDSANDQ---------ADSNILVDG---EQSILEQTASSLQGSQVDGVFCVAG-SVWSSAIAAKLATTH-KPGLLQLT-GA----HLTSGLPDNSAVLTPVT--------------------------------------------------------PLSFISEHLL-TT----------ETS----------------ENGT

                                      KPRVLLAASGSVAAIKFGNLCHCFTEWA-EVRAVVTKSLHF--LD--KLSLP-QEVTLYTDLHIELRRWADVLVIAPLSA-----KLDN-TCIIRAW-DYTKPLFVAPA----------------------------LMWNNPFTER----------------------------------------------------------------------------------------------------------------------------------------------------------------HLLSLDELG---ITLIPP---YGN--------------------------------------------------------EPSLIYTVR----WESQ

                                                                                                                                                                                                                                      MRKILITG----GFIGSALVYIINETSDAVVVVDKLTAGLMSLAPVAQFAFEKVD----ICDRAELARVFTEHQ--PDCVMHLAAETNIVGTYTLLEAARAYWAFRFHHIS--SDLVRAWLRGL---PTLITN---------------------------------------------------------CSNNY--RALY---CVA-TTGK

                                                                                                                                                                                                                                      MNIVVLIS---GNGSLQAIIDACNKIKGTVRAVFSADALERARQ-AG---IATHTLIA---YDELIHEIDMY--APDVVVL-AGFM----RILS-PAFVSHYAGRLLNIH-----LDG--------------------------------------------PVILQAKV---------------PVITRVQ--QEH-IYPVISWFADGRLK

                                                                                                                                                                                                                               EQGK-TNGKMVIAT---VGDIGKNIVGVLQCNNY-EIVDLGV-------------------------M---PAEKILRTAKNADLIGLS--GLITP-SLDEMVNVAKEMTIPLLIGGTTS-HT-VKIEQNYSGPTVYVQ---------------------------------------------------------------NASRTVVV-AA--LSD-QR-----------------------------------ETVRI

        FFED-IRGDGQHPTQSLLDLMTIYEEFNTFKGLTVSIHGD---SRVARSNAEVLTRLGARVLFSGPSE-------------EN-TFGTY-SM-EAVES-SDVVMLLRIQ------YL-YGLTVER-AERMKAIIMHPAPV---------NRGDDLVKSRI-------------------FKQM

WTGVFG--RSERGGAGS-SAFTTAVGVFEAKATVASLDGLTVLVQG-----GAVGGSLASLAAEAGAQLLVADTD-------TERVAHA-ALGHTAVALED-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------VLSTP---CDVFAPCAMG------GVITEVARTLDCSVVAGAA-NNVIASDILHARGILYAPANA--------------------------------------------------IHLV-----------------------VVHE---AIGDTLNQVFEISNDG---TPDEAARTLAGR-ARE

                                                                                                                                                                                                                                     NKNVIFVAGL---GGIGLDTSELLKRDLKNLVILDRIEN-PAAIAELKTVTFYPY------DVTV-IAETTKLLKTVDVLING--AGITIAVNTGLVNTTTAILGIICNI---GSKAVVNFTSSLTVTAYTVNP------------------------------NGAIW---------------KLDL-GT

                                                                                                                                                                                                                                    ANIRVAIAGA----GRMGRQLIAALAEGVQLGAALERSL-LS-AGEGAGKTVTVQS-------------SLDAVKDDFDVFIDFT-------RPEGTLNHLAFCHGKGMVIGT-TGF-GKQAIRDADIAIVFAAN---KV-----DA-GTALA-----------------------------------HKAS---RTFAN---GAVRSLSG---VL

                                                                                                                                                                                                                                      MKILITG-----GFIGSAVVHIIKNTQDTVVNIDKLT-NL-SLSDISEYNFEHA----DICDSAEITRIFEQYQ--PDAVMHLAAETNIVGTYALLEVARKYWFRFHHIS---SSLVRAWRR--GLPTIVTNC----------------------------------------------------------SNNY--RALH---MVV-TEG

       KT-----INIRNANFIKACLIRLY---TK------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------RGDSVLDLGC----GK--GGDLKYERAGIGEYYGVDIEVSINDARVRAR-VFFRAQ-----DSYGRHMDL-----GKEFDVISSQFS-HYFS-LDIAQRNIARHLRGYFIMTV-----MVDGFKRLGL-----------------------------------SLVE--FYEDE----------RRNP--------------------------------------ELSK-----CLT

            GYKSEVVRT---AEII-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------EGEVRR----------PVGLVLAISPFNYPVLAGSKIAPALIAGNVIAFKPPSISGLLLAEAFAVFNTITGR------GS-GDYIVEH--QAVNFINFT--G-----STGIGERIGKMAGMRPIMLEL--G---EQLE-----VGTVHI-------------------------------------------------------------------KTQ--RG--GAGIQ

                                      SKRALVILAKGAE-EETVIPVDV-RRAGIKVTVAGLAGVQCDVV------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IC----------PDAS-----------LEDAKKEGP-YDVVVLPGGGAQN--LSESVKEILKEQKGLIAAICAGPTALL-EIGF-------VTTHPLAKDKNG----GHYT--------------------------------YSENR-------PGTSFEFAAIVEALNGK---------------AA----------------LVL

                                                                                                                                                                                                                                     RLKIATIGGG---SSYTPELVGLIKRYVGELWLVDIKEKLEIVGALAKPIHLTL--------------DRRRALDGADFVTTQ--FRVGR-TIPVILDIIRDEPAWLINFTN--P-V-EAVLRTKQEKVVGLCNNH-----------VFGL-----------------------------------------GG-YYSDAACLISSIY-------DKR

          GKTTEYDIDAAW---QCIEYY--------------------------------------------------------------------------------------------------------------------------------------------------------------------------QLP-----------TRRE----------LGVCAGILAWNYPFMIAAWKCPALACGN-AVVFKPSPVTGVILAEIFHLVNVVQG----------GAETGSLLCHHVAKVSFT--G-----SVPTGKKVMEMSAKHVTL---ELGG--------------------NGT--RVF--------------VEVPF--------------------------------------------MSGFGRE

                                                                                                                                                                                                                                   MPNHQKVVLVGDGAVSSYAFAM----QQG---EEFVITKGDALDLEDAQ-PKKIYSG--------------EYSDCK--DADLVVI-TAGA-NILSSIVKPVVDSGFDGIFLVAANL-ATWKFSG--FP--RVIGSGT--------GDSEFAA-----------------------------------------GIGTALMRISIL--------------DENA-VL

                                                                                                                                                                                                                      GFT-----------VN-KTIIVTGGNRGLAFTRAVAAAG------ANVAVIVEVTEKVGKEF-GVKTKAYQCD---VSNIVTKTIQQID-GP-SGLIA--NAGNVFGVFNTCRAVAKLWQKGSIVVTSSC-LVKGLAAEW-AGIRVNA---------------------------------LSPG--------------------YVN-EEMTGQAIL--------DHA

                                                                                                                                                                                                                          TR---------AEKVAIITGSS--NGIGRATALFAR--EGAKVTITGRHRLEETR--QILENVNSVVA--DVTTDAILSTTLGKFG--KLDILVNNAGNLRSVIALTKKAVPHLSTKGEIVNI-SI--YIDLIQHG---IRVNSI---------TMKE----------------------------------------AGVMG---DIAEVIAF---LA----DRKTS

                                                                                                                                                                                                                                     MKAVAINGY----GTVGKRVAAIAQQDMKVIGVSKTRPDARMALK--KGYDLYVA-----------IPTVDDMLDEADIVIDC--TPEG--I--KNLKMYKEKGIKAIFQGG-EK----EDIG----DYTRVVSNT-------HHGPDVLD---------------------------------TPRV--------------------LEMEKYKSI

                                                                                                                                                                                                                          ERG--ADGTF--GAVVISP--TAYQSSIAWLGRLAS-QGFVVFTIDT---------------------NTTLDQS--GRQLLSALDARLGVMGH---SM-------GLEAAKSRTKAAIPLT--GWN-DKTW-PELRTPTLVVGADGD-PVAT------------------ESLKAYLELR--------------------GA--TSD--I--YSISWLKRD-------RYEQ

                                                                                                                                                                                                                                    EPIRVLVTGAA---GQIAYSLLSIGNGQPIILVLLDMMGVLDGVLMELQ--VIATD-------------KEEIAFKDLDVAILV--GSM--ANVKIFKCQGAALDVKVIVV--GNP-N-LTASK-PSINFSCLT-HS---------STQYPD-----------------------------------------SAAAICDHVRIW--------------FGTP

                                                                                                                                                                                                                                    KLVNIAVSGA----GMISNHLLKLASGQPIALKLLGSFQALEGVAMELE--VSIGI-------------DPYEVFEDVDWALLIG-AKPLDINGQIFADQGKALNVKVLVV--GNP-TNLICLK--IPNFHALTR----NHST----TQVPD------------------------------------------TASIADAI----------------KSVTP----TPE

                                       VNIAVNGH----NPMLSDIICDVAADGINIIGIC------------HEVMMRHGVPLATNSQELPIGALEAMVVDVQ---------CI---MPSLPRIAETQIITTDK----------HN-KISGATHVPFD-----------------------EH---------------------------NG-NI--QGIVLFVGC-NQDSAYVDLASLAK--RNVLVLATGAGAFAKAGL--ATLVMHMGSC-------VDNSRAVALATL-PLVASAPECM-SEKALAIGSWAVTIG---PTHVGS--VP--V--AKLVGGYF-IVD---------------------------------------------------------------DPKSAGDLYAAI--QE

SI----RPPM--ETP-TVQD--AQ-GCMTW---LAPQNGEHILDLCAA----GGKTTHILEVAPEA-QVVAVDIDEQR---LSRVYDNLKGMKATVKQG----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DGR--YPSQWCEQQ---FDRILLDAPCLAQLQSEILDAIW-PHLKGTLVYAT--EQIFLQRTADA-------------------------------------ELCETGQN

                                                                                                                                                                                                                              KSW---KIINVAVSGAA---GMISNHLLKLASGQPISLKLLGSFAALEGVAMELE--V-IGI-------------DPYEIFQDAEWALLIG-AKP-DINGQIFAEQGKALNVKVMVVGN-PC-TNLICL---IPNFHALTLD---NHST----TQVPD-----------------------------------VQTR---TASIVDAI---RSL---------------TPTPEGD

        EY----GFKQ-L-YHPTQMLADVLTMRDLHDISYAYLGDRN---NMGNSLLLIGAKLGMDVRIAAPAL---------PHFVAQCKLTLTEDPK-EAVKGVDFVHTDVW---SM---IKPYQ-VNMEIMK--AKFMHCLPAF------HNSLANGVFNIA--------------------FEAERMHTI

                                                                                                                                                                                                                                   QRRKKVAMIGS----GMIGGTMGLCALRELADVVLYDVKGMPEGKALDLSSVRAEY--------------SYE-ALTGADCVIVT--AGLLPFNSKIIREIGQNPKTFIIVV--TNPLCMVKVCE-PTNMICGMALD-HG-----DC--MVPL-----------------------------------------APAASAVAMAFLND------------EKRV

                                                                                                                                                                                                                                  KIIVKHVTVIGG----GLMGAGIAVAAATGH-TVVLVDQTDILAKSKKGILSIATSTD--------------AASVVHSTDLVVE-AIVENLKVKNELFKRLDKFAEHTIFASNT--L-SIAN---ATTRRFAGLH---------------------------PMTS-FE--------------------------------------------SLVDFSKAGKH---LLV--YPMGPFELYV

  NPI-----LG-CNFKACNNTDGIGLVTDLQRLNLRPNQHVLILGA----GGATKGVLLPLLQAQQNIVLANRT----EL--------ERFQIQAVSMDSIL--QTYDLVINATSA-G--------ASVD-AEILKLGSAFYDMQY------------------------------AKGTDT------------------------------------------------------------------------------------------------------------------------------------------------------------------PFIALCKSLGLTNVSDGF------------------------------------------------------------------------------------GMLVAQAAHSFHLW

          KPKS-GEVKAADR------DL-KI-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------GGVRRE----------PGVVAAITPFNYPLFDAVNKITSFIYGN-AVVVKPSPLPAAMAVKALLFIALLNLP---------GKEAEKIVADDRVAAVSFT-G-----STEVGERVVKVGGVKQYVM--ELGG

                                                                                                                                                                                                                                       MKVAVLGAAGGQALALLL-----QLP-GSELSLTPGVAV-LSHI-TAVKIKGFSG-------EDATPAL-EG----ADVVLISAGVNAGIVKNLVQQVAKTCPKACIGII-T--IAAEVLKAGV-DKLFGVT----GHSG---VTILP-------------------------------------------GQAAARFGLLVRAL-QG--------GVVE

                                                                                                                                                                                                                                 RKA--TAAVIFLHGLGDT--WAAFAGI-RSSHIKYICPHAP-------------------VR-SWFIKQAAENIKALIDV-RIILGGFSQ-----GA--LYTALTTQKLAGVTALSCWLP------PINRDISILQCH-LGSLTE-------------LKT---NPANVTFKTY---------------------GMSSC--MM--FIDKLLPP

                                                                                                                                                    KI-----------PGA------------------------YHIDYQTA--------------------QN--------AILD--GVALICG-QHLTVMKELLKNN------VFVVATAQAAGGLLNTYCKP-VFHMGS-------VDNSRAVDLLMAMVPFVASAPEAMSGKAAAIGTWWVSLG---VPTHVG--MPPVL-ASDVYG-YF-IFE------------------------------------------------------------PQVAARKILDALEYRTWK

                   SFDLVAQMIDEI---KMT-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------DDDLFVDLGS----GV-GQVVLQVAAATNCHHYGVEKADPAKYAETMDREYTLERGD-----FLS---EEWRERIANTSVIFVN---AFGPEVDHQLKERFANMKGRIVSS--KP--FAPDI-GTIM------------------------------------RVVELSPLK------------------GSVSW-VSY

     HLA--VDV------------GFPV-A---EVTSTDKILIIGGGI-GVPPLYELAKQLEKTGCQMTILLGFA--VKI---LENEFSNLKVTLKILMNEID-FEVDALYTCGAP--------AM-K-AVKKYD--QLERLYISM----ESRM-------------------CVE-----HDKQLSL

                                                                                                                                                                                                                                     CPAAVITG-GA---RRGHSIAVRLHQQGFRVVVHYRH-SEGAAQRLVANAVLCKGD-----LSLSLLDCCEDIIDRCDVLVNNA-SAYY-ELFGSNAVAPLFLILSVVNL---CDAKHGGLTRAAELRVNAVAP---------YR---------------------------EAS-----------------QIADAIAF--VS---------------KD---LKVDGG

                                                                                                                                                                                                                         AD-----------GCAVCVLGASRGRALAPQLARLL---SPGSVMLVSLRLKEELGAQQPDLKVVLAAAD----VQRLLSAVREL--RLQRLLLI--NAATALNLTSMLCLTSGTLNSKTVV--NISGKYQVLAAEEPSVR-VLYA----------------------------------------------------------GPLTSAQKLL--------GL---QKD--VDF

                                                                                                                                                                                                                                       EYAVVLKTSNWVDMKKGIEDEAKTLGVSVDIFASP---------------------SEGDFQSQLQLFEDLSKNYKGIAFA-------LSSVNLVMPVARAWIYLVNLDEK---IDMDNLKGG-NVEAFVTTDN-----EANGA------------------------------------------------TNVLQRNPNI----------------------------IYCAND-DGI

IM--VY-LQQ--VVC---GLPCTPLAIVKILEFLKIYYGKKCIVIN-RSE--IVGRPLAALLANDGATVYSVDV-----------------HHVEDLYSEDKKCSLDSDVVITGVPSE-----N-------KFP-TEYIAVCINFACTK---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------NFSDDV---KEKASLYVTGK-----------------------------------------------------------------------------------VTIAMLLRNMLRLV

                                      GSRVMVIGGD---GYCGWATALHLSKKNYEVCIVDNLVRR------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------SIHDRISSIELYVG----DICDFEFLAESFKSFE--PDSVVHFGEQNNVIGTLNVLFAIKEEECHLVKLG-------------------------TMGEYGT---DI--------EEGYIWGILNQGV-------------------GYL-DTVQCVEIAIA------------NP

                                                                                                                                                                                                                         QLT--------GLRFIDLFAG-------LGGFRLLESCGAECVYSNEWDKAQEVYEMNFG--EKPEGD---------ITQV-EK-IPDHDILCAG-FPCQADSRGTLFF-DIARIVPVVFMEN---------------------------NFAS--HDNG--TLEVVKNTMNELSFHAKVLND----FR-QNFQPKP--------------------------------------------FEL-NTFV

        DMEFK--------GVVPAVFNAVREFTK-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGDGVIIIT----PVY-YPFFMAIKNQERKIIECELLE--------------------YYTI---DFQKLEKLSKDNNKALLFCH-VWKKDELQKIKDIVLKSDLMLWSDE---VFQDEQLAD----KTITFTAP----------------------KNP----DI---------RE----------------------------------RFTK----SRD----------------------------TSGM

                                                                                                                                                                                                                      RLWGDH-------QEESAHVCLINA---TATGTEILNLVLPGIGSFTIIDGNNRAEAAMEFLQSGSFVEES-------ENLLD--PSFFCRFTVVVA-TQL--PESTSLRLADVLWNSQIPLLICR-MR----------IKEH------------------------------------------------PVIESH-PD--------------------------YIKLDNEIVLYLMLRAVDRFQQGRY--------SCLTGFLQEYG

GR--ANV-TL--RLLG---DNTDGVGLLSDERLS-IRPG-LRILLIGAGGASRGVLLPLLSLD----CAVTITNRTR-EEL----AKLFAHTGSIQALSMLEGH--EFDLIINATSSGI--SGD---IPAIPS---IHPIYCYDMF------YQKGKT---PFLNADGGML-------------------VAQAHAFL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PVIKQLQ

                                                                                                                                                                                                                                    KKLKV-TVFGTRPEAIK-APLVELKKYPEIDSYVTVT-RL--L--DAFHI-KPDFDLNIK---ALVRLDELFKDIK-PDIVLVHG---DTTTTFAGSL-AAFYHQIAVGHVE-AGLRQTGAIA------DLHFAPTQA--NL----KE----------NKK----SIFVTG----------------------AID----NI-LAKQLLTDPDE

               ALMSCLA-YEAPADAY----DWSAVRHVLDVG----GG--GGMLAAIALRAPHLRGTLVELAGP--AERA-RRFADAGL---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AVTVAEGD-----F---FKP--LPVT---ADVVLLSFVLNWS-DALTILRGCVRALERLLVLD-----LAGSAGL---------------------------------------ALASERTSG

                                      SLFDVQVKHEY-RQLLNCLHVITL---PRTVMIGGKAAP-YHMAKMIIKL------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ITAIGDVVNLRVIFLENYR------VLAEKVIPAA----DLSEQITEA-----SGTGNMFM-LNGALTIGT---MDGANVEMAEEA--NFFIFGMRV-------ED-------------------------------------------RI---VFYEYVKCQEVSALYKN

                                                                                                                                                                                                                       KVQGY--------ANVKVGIIDT---GNGHGTHVAGVAAAPNVSLYAIKV---LNSS----------------SGSYSAIVSGIEWATNGLDVINMSL--GGPS--GS-LKQAVDKAYIVVVAAAG-IGYPKY-DS------VIAVGA-SSVG-------SE-----------------EVMA----------------------VSLN-TSMASPVAGAAALILVR---INV

                                                                                                                                                                                                                                   MTNIRVAIVGY----GNLGRSVELIAKQPMDLVGIFSRRA-TLDTK-----TPVFDV------------ADVDKHADDVDVLFLC--MGSATDIPEQAPKFA--QFACTVDT---YD--HRQVMNEATNVALVTGWD--------SI----NRVY----------------------------------PGL-SQ

                                                                                                                                                                                                                                       RISIFGL----GYVGAVCACLSARGHEVIGVDVSSTKIDLIGKSLQQLSGTT--------------DFKKAVLDSDVSFIC--VGTPLGYIETVCREIGFAIHTVVVRST--V-VVIPL--KADFGVGTNPE----------------------------------------------------------KDYD---------------QTGDLLEEIYRELDIKYTCNV

                                                                                                                                                                                                                                    TPMRVAVTGAA---GQICYSLLRIANGQPVILQLLEAQKALQGVMMEID--TAH-A-------------DPMTAFKDADVALLVG-ARP-EANAQIFTVQGKAIDIKVLVVGN-PA-TNYIAMKSPSLNFTAMLHSP-------TM--YAD------------------------------------VGKR---AANAAIDHI--HDWV--------------LGTAGK

                                                                                                                                                                                                                     APQAWIA--------SGAKIAIVDTNG--NGHGTHCAIAAAAPKASILAVRV---LDN------------------GTWT--ANGITYAADQGAKVISLSLGG-VGN---GLQQAVNYAWSVVVAAA---NYPYY-SN------AIAVASSTYGS--------VV----------------DVAA----------------------SW-LSTSMATPVAGVAGLL-AIE--------TAD----------------------ISGTGT

                                                                                                                                                                                           DLP-----------------AA--------LK-------NP-TRPFLAIL-GAKV--LIDNLLDKV-----DSIIIGGGAF-AKLMEKAKAVEVVLPV-GL---DNGSRKLFAATVAKATVILWNGPGVFE----AGTKALLDEVKSSVIIGGGDTATVAKKGVTDK--ISHVSTG-------------------------------------------------------------ELLEG-----------------------KE

 DSNLY-----I--FLV-VDPCTPKGCLELIKETGPIAGRHAVVVGRSK---IVGAPMHDLLLWNNATVTTCHS-----------------------KTAHDEEVNKGDILVVATGQ----------------VKGEWIKIVIDCGI-----NYKV------VAYITP-----------------VPGGVGPMAMLSTV

                                                                                                                                                                                                                                      TTHLVWFRQ--DLR--LHALAACRNSSARVLALYIA-QLNGLQIALAGIPLLFREVDD---FVASVEIVKQVCASVTHLFYNY--QYEVNERARDVEVERALRNVVCEGFD-------------------DS-LPPG------VMT--------------------------------------------PECV--------------------------------------------AA--PK

                                                                                                                                                                                                                                    EPLRVLELYS------GVGGMHHLREIPAQVVAAIDVNTANEVYKYNFPHTQLLAKT---------IEGI-LEEFDSFDMILMS--PP------NSFLHILDILPPYILLENV--F-TRDLLIQTINGF----------------------------------QYQEFLLSS--------------LGIP

                                                                                                                                                                                                                                     MVNVAVNGY----GTIGKRVAAIIKQPMKLVGVAKTSPNAFIAHR--RGIRIYVPS-EES--------TVEDLIKTSDIVVDT--TPN-----GVGAQYKPIYQRNAIFQGG----EKAEVAD---KYIRVVSCNT-------HHAKD---IR-------------------------------TPRI

                                                                                                                                                                                                                                    ESLRIIFAGT----PDFAARHLALLSSGH-NVVGVFTPPSKVLAEE----KGLPVFQPV---SLRPNQQLVAELQ--ADVMVVVAYG-----LI-LPKAVLEMPRLGCINVH---------------------GSLWR-------DA---------------GDM-LYKLSC---------------PI-TL-KLAE-GPGLIT--LK--ADGTA

                  NG-----AKQALFNAFMA--LD---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------PGDEVIVFSP-----VWVSYIPQIILAGGTVNVVETF--------------------SKNFQP--SLEEVEGLLVGKTKAVLINN-VVYR--REFLEGLVRLANFYIISDE---TSILDVSEG---DRIVYINGF-----------------------------------RVGYL--SE--------------------------------KVATAVSKIQS---HTTS---------------------INT

      GKLF---SNLMLGGC----KTLRYCDKI-----------------------------------------------------------------------------------------------------------------------------------------------------------------------PMD-----------TRSE-----------GVCGQIIPWNFPLLMFLWKIPALSCGN-TVVVKPAPLTALHMGSLIKVVNIVPGY---------GPTAGAAISMDVDKVAFT--G-----STEVGKLIKEAAGLKRVSLEL-GG---------------------AAS--RLF

                                                                                                                                                                                                                                    DGKVAIITG------LGGLAIATKFVEEGAKVMITGRHSVGEKAAKSVGTIQFFQH----DS---SDEDGWTLF-PVSTLVNNA--GIAV-KLLAVNLDGVFFGTIINMS------YSKGAVRIMSKVNTVHPGY------------------------------------------------------IGE----DIAYICVY----ASNES--------FV----VDG

                                                                                                                                                                                                                                      MYIIIAGI----GRVGYTLASLSEKGHDIVLIDIDKDICKKASAEI-DALVING-----DC---TKIKTLEGIEDADMYIAV--TG----KEEVNLMSSLLAKNKTIA---RISE-YDVFERLG---DVVVSP-EL-------------------------------IAAN----------EKL

                                      SMFDVQVKRIHEYK--RQLLNCLHVI-PRTVIIGGKAAP-YHMAKMI---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------IKLITSVADVVIFLENYR-------V-AEKVIPAT---DLSEQISTEA-----SGTGNMKFMLNGALTIGT---MDGANVEMAEEA--NLFIFGMRI--------D--------------------------------------------EYALKVFDY-YV-CQDKVS--QL

                                                                                                                                                                                                                              KMKKE-RELRLLML--LDNAGTILKKF---EHRGFKLNIWDVG-------------------------GQKSLRSYWRNYFESTDGLIWVV-----R---D-CQRELQSLLATLLIFAN-----ALE-LDSISHHWRIQG------------------------------------------------------------TGEDLLPGIDLLDDISS

LC-AATA--PELTA----LDSDQGPTAAKYI--KVKP--QRIAIVHDKQQGEGLARAVQDGLKKNANVVFFDGIT---------------------AG-TLVARLKNIDFVYYGGYH------------QILRQARALKTQFMGPEGV----N--VSL----------------SNI-------ESAEGLL-TKP------KN-------DQK--DA-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AFVWTT--------------------DDPAEIAKYLKA--NSV

                     GGSHGILMATAI---CD-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------AGDYALVPQP-----GFPHYEVCKAYGI-GMHFYNCR--------------------NDWEA---DLDEIRRLKDDKTKLLIVTPCSNFSKHVEDIVRLAEELRLPLFSDE---SVADFETT----V-PRVILGTN---------------------------------WRLGWL--PH--------------------------------SFLEGLKRVGML

                                                                                                                                                                                                                                      MNIVVLISG--NGSNLQAIIACKTNKG-TVRAVFSADALERARQ---AGIATHTLIA----REY-RELIHEIDMYAPDVVVLAGFMRIL-----SPAFVSHYAGRLLNIH------------------------LLPK--QAL--EH---------SV----GPVILQAK----------------DITA-QEHAIYPLVIS--A----DGRL

                                                                                                                                                                                                                                     SKVALITGV----GQDGSYLAFLLEKGY-EVHGIKR-----------PKFHLHYG------DL-SDTSNLTRILRVQPDEVYNLGA--ADVDAMGTLRLLEAIRKTRFYQAS--KAYWVNYRESYG-MYACNGI---------------------------------------------------------FNH-DYVKMQWM---------QE-----IAT--------GVQY

                                                                                                                                                                                                                                       MKIAVIG---QSLFGQEVYQLRKEGH-EVVGVFT-ADGLEA-K----DGVPVFKFP----RWEVVAKYQALG---AELNVLPFCSQ-----FIPMEVINAPRHGSIIY----------------------HPSLLRG----DKK-----------------DLLLQKEC------------------RFLF--EGIKGMVAVRLIA-EGTAP

                                                                                                                                                                                                                                     KDTIALVVTLNNFVSLKDGAQKEADKLGYNLVVLDS------------------------QNNPAKELANVQDLTGTKILLIN--PT----RSDAVGNAVKMANIPVITLDRQ---AT-KGE------VSHIASDN-SA---RERGE----EK-------NDGAATIAQLVDLKLVVKQ

                                                                                                                                                                                                                                MK--APVRVAVTGAA---GQIGYSLLRIAAGQPVILQLLEAMKALEGVVMELE--L-ATD-------------DPDVAFKDADYALLVG-AAPLQVNGKIFTEQGRALAVKVLVVGNAN--N-LIAYKN-LNNFTAMTHSS----------IMFP-DL-----------------------------------QR--SAASAA--IR---DWAL--------------GTPEG

                                                                                                                                                                                      AAKGKTRY-----------------PAA-------------------PGDEVIIPAP-----FWVSYPEMVKLAEGTPVILPTT-------------------ETQFKV---SPEQIRQAITPKTKLLVFNS-MVYT--PDEVRAIAQVAAGLWVLSDE--HLSIGAASPEA-ERSVVCSGF-----------------------------------RVGFLAPV---------------------------------PLVA-AT-------NVCT------FAQ--------------GAI

   VIS----------DLDMV----KCL-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------HGKRHE-----------GVCGQIIPW-NFPLLMQAWKPALATGNVVVMKVAEQ-TPLTALYVANVVNIVPGF---------GPTAGAAIASHVDKVAFT--G-----STEIGRVIQVAAGKRVTLE---LG-----------------CAGS------RTFV--------------------------------------------------CYDV-------MSGSGRE

                                                                                                                                                                                                                                     MKKILLLNGLNMLLSIEQHLQSAQA-QGYELDYFQA------------------------NGEESLINRIHQAFQNTDFIIIN--PGAF---SVAIRDALLAVSIPFIEVHL---SYLSDV-------AKGVIC------------------------------------------------------GL---GAKGYDYALFAISELQK