1   .   10    .   20    .   30    .   40    .   50    .   60    .   70    .   80    .   90    .  100    .  110    .  120    .  130    .  140    .  150    .  160    .  170    .  180    .  190    .  200    .  210    .  220    .  230    .  240    .  250    .  260    .  270    .  280    .  290    .  300    .  310    .  320
MKTLIEIKQTPDGIIKADKVFNKVKDKISLPNRILYLGCGSSHFLSKLLAMVTNMHGGLGIALPCSEFLYSKETYPIGEVELAVGISRSGETTEILLALEKINVKKLGITTRESSLTRMCDYSLVVPAIEESVVMTHSFTSFYFAYLQLLRYSYGLPPLNAGEISKATEKSLEYERYIREIVESFDFQNIIFLGSGLLYPVALEASLKMKEMSIFWSEAYPTFEVRHGFKAIADEKTLVVLMVEEPFEWHEKLVKEFKNQGAKVLVISNSPQDLGQDYSIELPRLSKDANPIPYLPIVQLLSYYKAVSRGLNPDNPRFLDKVVRW

HYMQKEIYEQPNAIKNTLT--R--LSEADKVEHIQILACGTSYNSGMVSRYWFESLGIPCDVEIASEFRYRKS---VRRNSLMITLSQSGETADTLAGLRLSKLGSLAICNVPSSLVRESDLALMTNATEIGVASTKAFTTQLTVLLMLVAKLSKEHVHGLQALPSRIEQMLSQDKRIEALAEDFDKHHALFLGRGDQYPIALEGALKLKEISYIHAEAYAAGELKHGPLALIDADMPVIVVAPNLE-KLKSNIEEVRARGGQLYVFADQDAGFVMHIIEMPHVE-EVIAPIFYTVPLQLLAYHVALIKGTDVDQPRNLAKSVTV

PG--LGWVDWPI--RYDKNEFS------RIRDALVVIGIGGSYLGARA--------TTQIYFAGQNI--STISHL--DVLESINV-ISKGTTTEPAIAFRIF-YMIYVTTDRTGALKK-------FVIPIG---GRY-SVLVGLLPIAVAG-------LNIDRMMEGAASAYKY-NESYQYAAVRILYIELLVNEPSLHYVSEWWKQLFGESEGLFPASVDFTTDLHSMGQYVR-LIETVLHV-K-EVNKKAFQGTLLAHVPNLIVELDE----------------MNETFGEMVYFFEKACGISGHLLGVNPFDQPGVEAY

IN--VL---HVALRPEVNKVLDK-A---RVITDVINIGIGGSDLGPLM--T---SSGPRVWFVSNID--GTIAKT---ACLLFIIASKTFTTQETITNAKTAWFHFVALSTNTAKVKEFG-----FEFWVG---GRYSLWSIG-LSIALHVG------DNFEQLLSGAHWMDQHFNAPVLLAMLGWYITQAVLPDQYLHRFAAYFQQGDMESNGPIVWGEPGTNGQHAFYQLI--MIPCDFLIPV-LANFLAQTEALMKGNRPTNSIVFT----------------LTPILGALIAMYEHKIFVQG-----NSFDQ-GVE

                                                                                                                                                              EILNELHNSAAY--ISNEEADQLAD-HSSHQIFTAGAGRSGLMAKSFAMRLMH-MGFNAHIVG-------TPP-LAEGDLVIIGSGSGEKSLIHTAAKAKSLHGIVAALTINPEGKQADLIIRMPG-MGSLFEQTLLLFYDAVILKLMEKKGLDSETMF-----ANL

                                                                                                                                                              KEWQEHQKIVQAS-ELKGQIAKVGELECLGKILICGNGGSAADAQHFAAELSGRKALAGIALT-FVFSRQVEALGNEKDVLIGISTSGK-PVLEALKKAKELNLCLGLSGKGGGNKLCDHNLVVPSDDTARIQE-HILIIHTLCQIIDESF

                                                                                                                                                             LEELDIVSNNILILKKFKNKLDSLID-RKAKKIFIFGVGRSGYIGRCFAMRLMHL-GFKSYFVG-----ET--PSYEKDDLLILISGSGR-EVLTVAKKAKNINNNIIAIVEG--VEFADLTIPLEVKKGTTFEETALIFLDLVIAEIMR--LNLDESE-KR-HNLL

                                                                                                                                                                 DDYAAGV----ILDERIRVAAKFLRYEPILLVAARQY---AHKPVQFSKV---GSDYIVGRFI-GTSEYREPE---VVFVND-PA----KQAVSEATAVGIPVVALCDNNSSADVDLVIPTN------GRRALAIVYWLLAREIAKIRGQDFT------ELEG

                                                                                                                                                                     ANT------LVLAARIIAAIPEDVVAISSRTFGQRAVLKFAAHT-----GATPIAG--RFTPGSFYKEP--RLVIVTD-PRS--DAQAIKEASYVNIPVIALTDLSPSEFVDVAIPCN------GKHSIGLIWYLLAREVLRLRGALVD

                                                                                                                                                                        GVH---FNEALAELNKIAGKILFVGTKRAASEAVKDAALSC-----DQFFVNH--RWLGGML-LP---DALFVID--DH---HIAIKEANNLGIPVFAIVDTSDPDGVDFVIPGNDD----AIRAVTLYLGAVAATVREGRSQDLA

                                                                                                                                                                     AGV------LERTFRFIEDLAGTILFVGTKKQAQDIVRMEAERAG-----MPYVNQ-RWLGG-MLFRLP--DAIFVVD--TK--EAIAVREARKLFIPVIALADTSDPDLVDYIIPGND-----AIRSIQLILSRAVDLIIQARGGVVE

                              AKITVVGCGGAGNNTITRLKGIE----GAKTVAI--KIAEE---------------------------------------------------------------------------------------------------------------------------------------------------------IK-AAIQDS---DMVFITCGLGTGSAPVVAEISKKIGALTVAVVTL-LERHTDTLVVIPNEAFKVADEVLINAVKGLVELIDGNV

                              AVIKVIGVGGGGGNAVNHMA----NVEG-VEFICANVLRERI-----------------------------------------------------------------------------------------------------------------------------------------------------------EVLEGA---DMVFITTGMGTGAAPIIAEVAKEMGILTVAVVTR-IRASVDSLITIPN-AFAKADDVLAGAVRGISDIIRP

                                                                                                                                                FCI---PNHYAE------PHGLIMDRTERLARDVMKEMGGHHI--VALCVLKGGYK-FA------KASI-MTVDFIRLVIGG-DDLSTLTGKNVLIVEDIIDGKTMQTLLSLVRQYNPVKVASLLVKYK-----DFVGFEIVVGY

                                                                                                                                                                       LLPL-----GLREAAA-LEAKRIRVHGDYDGLTGTAILVRGLAA-LGADVHPFIPL--RPEHLEAS---DLFLTVDC-IT--NHAELRELLENGVEVIVTDHTPGPPPGLVVHP--KP-------TGAGVAFLLLWALHRL-GLPPP--SWVGLLAE

                                RLVGVTGTN---GKTTTTQLLAQWSSFCAEVSSHGLVQHR-----LKFAASVFTN----EAAW-LLYSEHHCGQAIINADDRRWLAKLDAVAVSE-----------FNVSNLLLALA--GYPDLLK---AR--------RLHCAGKL-------WCV--------------------------GCG

                                                                                                                                                             KHT--PEAEIKARIAELGRQITERYKDSGSDMVLVGLLRGS-FMMADLCREVQ----SHEVDFMTA--KDL--EDIRGKDVLIVEDIIDGNTLSKVREILSLREPLAICTLLD-VNVPV--EFIGFIP-VVGYG

                                                                                                                                                   AD-VPPHKP-KIL--PGGLVKDRVEKLAYDIHRTYF--EE-LHIICILKGSRGFFN--ID--AT-P--FEHYVRLVLS--DDLSIFRDKHVLIVEDIVDGFTLTEFGERLKAVGPMRIATLVE-SLK----DFVGFSVWVGC

                                                                                                                                   VDLKYTEW--R----VDK---------SSFPVMNYGTYLR---TVGA--EF---ANKVQVVNLG--CGSD--LRMLPLLQMFPHLAYVDIDL-TTRLLDVTKREIPTIVISECLLNNESQLLINTIMSKSHGLWISYDPIASRW

                                                                                                                                                FM----IPAH-YK-----PNGVIKNRIEKLAYDIKKVYN-EEF--HILCLLKGSRGFFT------SRIKPLGEHYVRVIVS--EDLSCLKGKHVLIVEDIIDGKTLVKFCEYLKKIKTVAIACLFI-FK-----DFVGFSIFVVGYS

                                                                                                                                                                             NLDNAIDMI---EANSIIITPGCKAQYPIADLVKMLTE-QGKKVRFG--IHEMDEINHDFPDTDLVLVIG--ANDTVNS---EVWK-SKQVIVMKRSLG-IF-TAMLLGD-------KKTCDALQAK----VRE

     DQIPVHTLERAMREYYANIVNPYAP-----------------------------------------------------------------------------------------------------------------------------------------------------------PTNKVVIFYDHSTEKMARVLAESFRDEG-CTVKLMWCKACH-QIMSEIS-GAVIVGSPTHILPYVAGTLQYIKGLRPIGGAFGGEKV--WLT--P-K--K---NVPT-DYEQLKTMAQTIARA

                                                                                                                                                                                           NIIVFYGSGTAEEFANRLSKDAHRYGMRGMSA----DPEEY----DLSSLLVVFCMATYDP-AQDFYDW--DLTVKFVFGLGFNAKYVDQELGLGDDD---NLEEDFITWREQFWPAVCEFFGVEATG-----SSIVH

YQT---LPE----------PDVQAVTRLTLL----------------------------------------------------------------------------------------------------------------------------------------------------------AERPLIYYGIRKAGKELEQLSKTLK------IPLMSTYSANQKPANELAQADVVLFVG-----NY-PFAEKAFK-NTRFLQIDIDPAKRHKTDIAVLA------DAQKTLAAIL---AQVS------ERES

                                                                                                                                                                                           MKVTIIGSGRVGSATALLLAK--EPFMKDLVLIG--RSDEN-LRIID-ESDVVIITGTNAKIVGKYAKKIAEICDTKIFVIVDVMYKALQVFGLGT-GEQIGSEGPAAAILNVVR-VN

AFR---GAP--QM--GA--APDDAIDQVKLIA---------------------------------------------------------------------------------------------------------------------------------------------------------QAKNPIFLLASQ---ALRRLLETSH------IPVTSTYRVGQAGDRLLQLADLVICIG---SPVE-EP-AMWNS-NATLVHIDVLPAYEYTPDVELVGD-----IAGTLNKLAQN--------IDH

                                                                                                                                                   FF--RNDVVK-----TFEECKALAADTARRMNEYYKDVEPVTLVALLT--GAYL----------TF--TLHFVKVS-FDEEDLKQLEKREVVLIDEYVDSHTIFSIQEQIK---HAKICSCFVKDV-LTKMFYGY----IGF

                                                                                                                                                           MDD-ERVNQDDIQKRIRELAAELTEFYE--KNPVMICVLT-GAV----FFYTD-LKDFQLEPDYIICS--ISKDLKNIEGRHVLVVEDIIDTLTMYQLLNNLQMRKPLKVCTLCDKADVPI-DYCGFVV-YIIGYG

                                                                                                                                                   YEFA------KI---TEEEIRTRIKEVAKRIADDYKGKG-NPVLISVLKGS-FMTADLCRA-CDNV-PVRMEFICV--LDTR-HSIEGHHVLIVEDIVNALTLNYLYHMYFTRRPLKTVVLLD-PFS---DYVVA-NI-VIGYG

                                                                                                                                                                                           RECISIHGVQIGNA--W---------TI---AVFV-IVLDRIRKLA--LQGFSVFHSFGSGFTSLLMERLSVDYKSKLEFSIY-LTTTHSDCAFMVDNTYTNLNLIGQIVSSITASLRFD---GA

                                                                                                                                                                                           KKILLLNGPNLNTL-SDIEQHLQQSAQYELDYFQAESLIN-RIHQAF-TDFIIINPGATHTS-VAIRDALLAVSIPFIEVHNVHHSYVAKGVICG----------LGAKGYDYALD--ISLQ

                               PKALIVYGSNTEYTAETIARQLANAGYEVDSRDAASVE---------GFDLVLLGCST-LQDDFIPLLEETGAKVACFGCG-DAIEEKLKIQDGLRID-----GDP--ADIVGWAHDVR-GA

    PIFRNPGLF----------------------------------------------------------------------------------------------------------------------------------------------------------QKLIDAF--HLEEAFPEVKI-DYIVGLESRGFLFGPTLALALG-----VGFVP-VRK--EIQKNAIAGSNVIIVDDIIATGSAAAAGELVEQLEANLYNFVME-RSKLNAPVFTLL

                                                                                                                                                                         FGL------KDLISDCSSTTYVLVTDTNIGSYTP-F-EEF-RKASPRLLIYNR-DIE-DWMLPCGRDTVVIALGGGV--IGDLTGFVASTYGVRYVQVPMVDSGGQPTKIYIDLLETL-------------------HLGILKGVA

           AARKSL---------PLLPAPKILVAGS--HADTILEAVKAAV-DPTVVVFAEN--PDEF-KS---GGFSYAIVAVGE-IPEPGLSTVQAVGVRCATVLIPVVPLLAASDALVAAW---------LPGS--QGVTDALFGD

    EIATS---------EFVMQSINKADLIKKPVLYVGAGI-----PLLKELSDRAQIPVTTT--MLGMHGCATA---------------------------------------------------------------------------------------------------------------------------------------------------------NLAVQNADLIIAVGARFDDR---VT---FAPEAGIIHFEVSPKKVVQTQIAVEGD------TTNLGKMMSKIF------PV-----KE

                                                                                                                                                                                           INALTIAGTDGIQADLKTFSALG----AYGCSVITVQLD-SVFSDV---DTTKIGMLAETDIVEAVAERLQRHHVRNVVLDTM-LRLPQVSLITPN-------GTGCTLSAALAALRPRHR----HFHAW

                                                                                                                                                                                         SKIRVLSVDDS--ALMRQIMTEIINSHSDMEMVATAPDVARDLIKKFNP--DVLTLDVEMPRMDGLDFLEKLMLRPMPVVMVSSGSERALGAIDFTKP------QLGI--AYSEMIA

                                                                                                                                                                                           KKILIVDD--EKPISDIIKFNMTKEG-YEVVTAFNGEALEQ-EAEQ--PDIIILDLM---IDGLEVAKTIRTSSVPILMLSAKFDIGGADDYVTKP------------FSNRELQA

                                                                                                                                                                                           TTVYLAG----DSTMAGWGEYLASYLSATVVNDAYTGRFENIADVVTAGDYVIVEFGHFPAYLENAAKLFTAKGAKVILSSVEELAAAGVEYVDHW-VNYFAGAE-VAEAFLK----LTT

                                                                                                                                                                                          GKRVLIVDDAFMRMMLKDIITKAG----YEVAGEATNEAVEKYKELK---DIVTMDITMPEMNGIDAIKEIMKIDAKIIVCSAQQAMEAIKDFIVK---------PFQPSRVVEAL

                                                                                                                                                                                           DTLLILGD-SL-AG--AWPALLNDKWSTSVVNASGLARLPALLKQP---RWVLVELGGTEQTLRQILQDVKAANAEPLLMQISAIYLAVPLLPF-FM---DGIHP---FIADWMAK

                               CKIVVVGDQCGKTALLH---A-TASELSLWDTSGSP---YDNVRSYPDSDAVLICFDI--LDSVLKWKGEIQTKMLLVG-GANMAKQIGAATYIE-----------CSA-SVRDIFHV-VNK

                                                                                                             LMG---EF--DPR-------------------VGV------------TGHTPIMFQKA-VGGTGARQALELARMANPDLRVFVS-----PTW---HVSMN--GL-PVQTYRY-FEGMKADLAAAKKGDMVLLHGCCTLDQWAEIASILEKTGALPLIDLYQATRLIAVLIAASCSK

                                                                                                                                                                 HV--SSS-VR-LNDQDLDILVKA-SASPAIVLGP--VD---NADCVMLAE--RLKAPVWVAPLMP---LL-EGHDVVLVIGA------PVF-----YLKGTRLISVTCDPLARAGDAIVAD-----------IGAMASALANLVE-ES

                            KKDLKVVAT-----NSIIADITKNAGD-KIDLHSIV-YEP--LPE---K-EADLIFYNGIN--TAWFTKLVENAKKDYFAVS--------------DGVDVIY---WLNNGIIFAKNIAKQLS--NKE---NLKE-TDKDKESKDKFNK

                                                                                                                                         VAVFLGV-----------DEG--WVL-----LGGTGARIGAEFLRRWYNATPVYVS-----SPTW--HN------FKDIRTYRY-LQGLLSDMEKAPEFSIFILHACATPDEWKQIAAVMKRRCLFPFFDSADAVRYF-LFCAQSF-------------------------TWSN--PPSQGARATT

                                                                                                                                                                                         QFKNIIVTG-GA-GFIGSNFVHYVYNNHPDVHVTVLDILV--KLAAKA---DAIVHYAA-NFIGTYTLLEAARKYDIRFHHVSTKAALIV-ATISNCSNNY-EK-----NDHSTGVW

                                                                                                                                                                                         MAVKKIAIFGGQTGLTTLAQAVQAG------YEVTVL-DV--KTVAGQ---DAVIVLLG-MSEGARNIVAAMKAHGVDKVVACTHIHKVLLKYVAVMPPHI--G-KHDLGHFMLRC

                                                                                                                                                                                           RVALTIAGSD---AGVQADLKVFFRFGVYGTSALT-VVYAQ-ESVA-PLHAAKTGA-GDAAIVEAVAEAVRRFGVRLVVDPVM-KERLADLVTPNRLE-HT-HGTGCTLSAAIAA-EA

                                                                                                                                                            NTP-------------GWQKAADQAAA--EAKHPVLVVGAAI-VAIRALAER------LNIPVITTYGAVGY--T-PV--DLVLTVG-DYA-DLR---PSWQKGIKKTVRISPNPIPYRPDVDVVT----------DVLAFVEHFETATASFG

                                                                                                                              IYE-------------------------------SF----CGSV--AT------FVSSAAAAPILCDA----EMVAHGV--T-RARLGNEVICTLSAAALKLWSERLA-GSVVAIGNAP---TALFFLLEMLAPKPAILGMPVAAEKDALFAIVR-LG---------SAMTAAALNSLAR

              QRAQM-------------HGIAVAGTHGKTTTAMISMIYTQAKLYLIAEADEFLH----------QPMVSVVTNM--KATYVKFLHNLPFYGLAVMCAMELV-VGRQVITYGFS-------HALNATAALAVAKEEGI----ANE---------------GW------VMIF

                                                                                                                                                                                           LIVNVINGPNLGH---ELVALIEREAALKAVVRQSAQLLD--HQAAAAEPVILNAGG-THTS-VALRDACAELSAPLIEVHVRRHSYIATGVIVG----------LGIQGYLLALRY

                                                                                                                                                   VLKITEEML-FAS--VC--YD---------MQRLYD-QGHRNISYLGVPTTGKRRHEAYLAFCKAHKLHPVAALPG-NVAKVITP---TTALLCATDT----ALGASKYL-IDTLQLASVG-TPLMLHEIVTVDPGY---------------------AQVTGRSEP

                                IGIFFGTGNAEAIAEKISKAIG----NAEVVDVAKAS----QF--GFTKVILVAP-TALQTDWEDFLGTLDFIGLVGLGFAEGIFHIY-VGLVIDED---QD-----DLTDERIAKWVEQVRG

                                                                                                                                                                                           GIVWVVDD---DSSIRWVLERALAGAGLTCTTFENGNEVLAALKTP---DVLLSDIR--PG-GLALLKQIKQPMLPVIIMTAHSDDAA-FDYLPKP------------FDIDEAVALVE

                                                                                                                                                                                           MVLTVTLNPA---KGINVSIALSKLGVPSVATGF---FLRRYKMTLS-VDCVVISGSI-EGICNELVRLARERGVFVFVEQTPERIYFPNVVKPDLRG-LL------GAGDAYVAG--IKHG--LEA

                                                                                                                                                 LI-NL------CQP---------LGGTGARIGAEFLARWYN-TPVYVS-----PTW---HN------FKDIRSYRY-LQGFLSDLENAPEFSIFVLHACATPEQWKQIASVMKRRFLFPFFDSYQ-IRYFFLFCAQSF

                                                                                                                                                                                           KTVIITG----RGLGAEAARQAVAAG-ARVVLAD--HLD-RVVAY---VDGLVNNA-S-VEINLTGVFIGMKTVIIVNISSAAGWGVLSVNSVHPGM--TA---GEPGEIAGAVV

                                                                                                                                                                                           KNILAIQS---HVGNSAAEFPR--RLGANVWPLNT-HLTEI-IAKLH--DAVLSGYLGSAEQGEHILGIVRQVKAKYFCDPV-HVRHASDIIAPN--RQ--PVGVGDVTSGLLLV-KL-AT

                                                                                                                                                                                          ARRILVVED--EAPIREMVCFVLEQNG-FQPVEAEDYDSAVNQLNWP---DLILLDWM--GGSGIQFIKHLKTRDIPVVMLTARVLETGADDYIT------------KPFSP-ELV

                                                                                                                                                                                      LRLD-KCAIITG----AGIGKEIAITFAT-AGASVVVSD--CDIEALADFAI-DILVNNAGGGAYELNVFSFFHLSQLVAILTITSMAAAAALVVNGIAPG------AILGPQDIANAAL

                                                                                                                                              DLSD-YK--------YFLR-VVP----SD-LQ-----DI--RYNWTYVSAVHTEGGESGMDAFKELAAQEGLCIAHSDKI--LL--KLRERLPKAVVVCFCEGM-RGLLSA-------EFSLIGSDGRDVIANGGITIKLQ

                                                                                                                                         DP-ILLAD--------GKIGKTP-----EFGPGGGA----VAFLAKNTSVKRVWVS-----NPSWPNHKSVFN-SAGLEVREYAY-ALINSLNEA-QAGDVVLFHGCCTLEQWQTLAQLSVEKGWLPLFDFADAERAFALIVASSYKN

                                                                                                                                                                                         PPKVILLVEDSADSRLVQEVLKT---STIDHELIILRDAAA--FLSPR---NLILLD---LN-DGREVLAEIKQLKIPVVVLTTSHDAS-VNCYLTKS-----RNLKDLFKV-QGIESFLE

                                                                                                                                                                                           MNVLVIEDDKFRGLLEEYLSMKG-----IKVESAEREAYKLLSEKH--FNVVLLDLL---VNGLEILKWIKERSTEVIVITGIKTEAMGAYDFLT-------KPCM-LEEIEL------NELL

                                                                                                                                                                                           KRALVILAKGAEEETVIPVDV--RRAGIKVTVAGLAGSLEDAKKE-GPYDVVVLPGGNQ---ESAAVKEILK-EQEIAAICAG-LAHEIG--TTHPL---------GPGTSFEFALAIVENGEVQVK

                                                                                                                                                                                           LEVVTAGEPGAEVNVAVALARLG----VKVGFVG----FD-YLEGV---RFLHLSGITPRAFSLWAMEEAKRRGVRVSLDVNYLERAGVDLLFLSEEAVEA--GAGDAFAAGYLA-GA--L----LEV

                                                                                                           TL--------------ME-----------------IG--------------YNIP------LGGSGAKVGADFLKRYFPESGVWVS-----DPT----VA----AGFE-STYPW-FDLL-ATLKTLPARSIVLLHPCCTNDQWDAVIEILKARELIPFLDIADAIRAIAALVSNSF

                                                                                                                                                                                           YTVHIVDD--EEPVRKSLAFMLTMNGFAVKMHQSAEAFLAF-APDVR-NGVLVTLR-----SGVELLRNLGKINIPSIVITGDVPVEAAVDFIEKPFE-------------DTII

                               AMDITVS----IPPQQYF-EK--GDLVRVSVLV-EP-KPQQ------EAEAYVLIGLG--QPWLEKLKAANANMKLIDSA--------------QGITPLMPHILSLVKRQATTI-AK---ANRDQEA-LAAE-ERNQELGQILQQRK---NNLTMVF--------------------------GET----------------------------------------------------TKEAIAAGV

                                                                                                                                                                                          TGKIYLGSPRERAAKAKELLAKN--PS-IAHVFFP----DLTGISNA---TCGVFLYDMLDDGSAF-IGFMRAMHKPVILVPFTKMNIGVTTIIDGN---------TEFEKLADYN

                               VNVGTIGHVDH--GKTTLTAT-EYSHYAHTDCGHADYV-KNM--TAPLDGCILVVAADGPMPQTREHLLLAREHVVVYV-VELEIRELLTPIIVG-----------SALC----------------------------------------------------------------------------------------------------------------------------------------------------LGLKSVQKLLDVD--PVPTR

                                                                                                                                                                                           CRVLSIQSHV---GNRAATFPLQVL-GFEVDAVNSLLYDGL--VNQY--DYVLTGYTRDKSFLAMVVDIVQELKLVYVCDPVMLPVYKVDIITPN---VF--VGTGDLFAAMLLAW--IKCAK

                                                                                                                                               DDQDAIAVEAAC-ALF-----IIFS-----------HLVALGHQQIALLAGPSVSARLRLAGWHKYLTRNQIQPAEREGQQTMQM-LGIVP--TAMLVAN--Q--MALGAMRAI-GLDISVVGYDDTEDSYPPLTTIKQDF

                                                                                                                                      DPKQAVAVANKELTQ-----------RTAG--------LDSSQGETVK----PQRIAIIHQQYGEGLARSVQDGLKAANANVVFFDGIT----ALIARLKNIDFVYYGG--YYPEMGQMLRQARGLKTQFMGPE-GNASLAEGMLVTMP----------------------ALERT-ALVK

                                                                                                                                                                                           MKLYMSVDMTEANYCIAEAFNSG----CTEVLVNDSSMVE-GLDDT---FRGALFLGYHAGELGLNAYVAGYYDVPVLMVAGAAKEALIPNVTTAAVKC--PRGRLLTEKTAFA

                                                                                                                                                                                           PVVVVTG----RGIGKAIALSLGKA-GCKVLVNY--GDV-AMMKT---IDVVVNN---VIDLNLTGVFLCTQAATIINIASVVGAGVFSVNVVCPGF--TA---GQPENVAGLVE

                               KRLMVMAGGGHVFPGLAVAHHLMAQGWQVRWLG-TAFIRAI----AYKPDVVLGMG----GYVSGPGGLAALGIPVVLHE--KWLAKIATKVMQAFPG-----------GNPV-----------TDV----LA---LP------------------VRVLVVGARILNQTMPQV-AA--LGDSVTIWHQS--FI-DDMAAAYA--DVVVCR-------GALTVSEIAAAGLPALFVP--YWNAPLAKIIEQP---------LSVDAVANTLAG------AEARA-PDARVA

                                                                                                                                                                                           MNILLFG----TGQGWELQRSLA-PV-GNLIALD--CGV--TVRKLR-DVIVNAAA-H-QLLNATSVEAIAKAAAWVVHYSTYVKLAGEHLIFRTSW-----VYAGAELLADCTAH

                               LQVLVLNPPG---VSDALVLQLIRIGCSVRQCWP--PP-------DVPVDVVFTSI--FQNRHHDEIAALLGTTLVALVEVLSQIIELECHGVIT--------------QPLD--AHRVLP--------LVSARRISEEMAK

  VKP--ERISMLLS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTIHIGGTN----GKGSVANMVSNILVIAVLEVG-LGGRLDATNVVFPLCSTIVTVDR-IEQIAWEKSGII-KEVPLVTGERKREKVMEMYVI---KV------GPHQIENAGVAGL---PLS-KA

                                                                                                                                                    PVVER-----NI--VY-GGP---NQNAPLAAYLIRHYGERVVFIGSD---YIYPRESNHVMRQH--VLEEIYIP--DLQRAVERIY-DVVFSTVV--GT-GTAELYRAIARRRPPIASLT-SEAV-A-QVVVAWA--------------------GRAAQAAGNWRVED

                               KRVVLAFTRPEATK-APVYLALRGIPLKPLVLLTG-NLDQA-----EGADYVLVHG---DTLTTFAVAWAAGIPVGHVEAGRRLTDVLTDLDFAPT-------------GQT---------------------------------TVTYPVVR--------------------------------------------------AS-----------------------------------------------------------EGVYRVKENP------------AKNYG

                               KVALVT----GGASGL-VVKLLLGEGAKVAFSHV-DWTLVMAAVRLGTLNVLVNNAG--NTESVFIGCQQGIGSIINMASVKAAVSALTVNSIHPDG-----------------------------------YT-PMMQAS-----------------------------------------------------------------------------------------------------------------------YMPERIAQLVL

                                                                                                                                              TPVR--W--HQ--PFLYV--------------RE-E--FGKFFP-TYYSVLYFSYISDVGDTFIHQVNRDNNFELSAYYTGAAKA-SLAHPD-VDFIYACS--TD--ALGAVDALAGRDIMINGWGGGSAE-DLDITVMRMND

                                                                                                                                                                                           SKILVFGDSDAIGSSYAFAYLAREAYGLDTEAVALGVIT-AKAEGAE--QVILTDH--NEQQS--V--DIAEV-EVYGVVDHHRVANFETYMRLEPVG----SSSIVYRM----FKEHS-------VA

                                                                                                                                                                                           KIALVTG----SRGGRAIAETLAARG-AKVIGTA--MLNSSVLEGE--VDILVNNA---IETNLSSVFRLSKAVMIITIGSV-KAGLFSVNVVAPGF--MTR---GAQEIANAVA

                               TVVLITGCSS---IGLHLAVRLASDQSFKVYATLDSVAAARERVTEGRVDVLVCNAG--NVVGTVRMLQAFLGRVLVTGSVKFALEGLCLSLIECGP------------------------------------------FMEKVL-------------------------------------------------------------------------------------------------------------------QNPEEVAEVFL

                                                                                                                                                                        NLFQSV--------SAL-TADVTLVAWGTQVHVIREVASMAKEKLGVSCEVIDLR--VDTICKSVI-TGRLLISHEAGF--ASEISSTVQEECLPISRVCGYD-------------PF-PFY-IPDKWKCYDA

                               EKILIFGDTDTICSAIAYADLKNKLGFNAEPVRLGLVET--AN---EVNGVILVDH--NE-Q-QS--IKDIEVQVEVIDHHRI--ANFETPYRAEPVG--------CTATILNK------ENN------------------------------------------EKEIAGLLS

                                                                                                                                                                               TMVQALNRALEE-DLTLICYGTVMPEVLQAAAELAKAG-VSAEVLD-LR-WDAVMNSVA-GRVVLVSDAPRASFVSEVAATIAEDLAPPIRVTGFD-------------QD-----LPTVTRILNA

                                                                                                                                                                            SGMGAITSTLWTLLRDEVLLG-----NTL---F--FLHHGIGVKLRHVDMADLQAEAAMTT---RVIYFESP----DIAGVAKIARKHGATVVVDNYCQRPLGADLVVHSAGGMIA

                                                                                                                                                                                           PLVHNITNFVVMNTTANALLALG------ASPVMAHA-L-EMIRLA---DAVVINIGTLRRSMVKATEIANELGKPIVLDPVGASLEGVDVLKGNFG----VTGTGCMVAA-----KA

                                                                                                                                      DPK---AVANKVELTA----------RTTG--------LDSDQGEKVK----PQRIAIVHQQYGEGLARAVQDGLKKGNANVVFFDGIT--TL---ARLKNIDFVYYGG--YHPEMGQILRQARALKTQFMGPEGANVS-SAGLLVTKP------------------------NQSDEIAKY----LTWDE

                                                                                                         YNPFL------------LP-----------------LTD--------------NA---LKDK-HQG--ANIL-PVLLKYKQAPVFISNF-------HFDTAAHVE-LNGCKAINIVGDFDIKKLKENIADNIAIVSTVT-SMSNLKEVYEIAKQHGIFVVMDSAIFDYKYADALTMSADP

               KNV----------YLENKTVVIADEIVWKAGHTIVNELKKGNIAAEEVVFSNEVERINI-KAEAAIVIGVG---GG-KTLDTAKAVADYIVIVPTAAST-APTSPLVLVDIANAP--------------------------HSQQIERYIEL

                                                                                                             LF-----------------NT-----AH--GG--FS------------------ANI--LH--GETESIFTVASGLKPRRAMIV-----TPGF-AEY-GR--AQ-EIRRWSLTDAILEALTPDL---DCLFLCTPLPRPLLQAIADRCKSLNINLILDEFITGFALHIWVLRSLANYLL-----SAAQNERLLAALRNVL

                                                                                                                                                                                       KN-GARVVVIG----GFVGASYVFALMNQGIDEIVLID--A----DYDDCRDADLVVIC-GANIAIFRSIVESVMGFQGLFLVATNPDIYATWVIGSGHG--AA-I-TYGIAMGLARVLHN

                                                                                                                                                                                           KKILVVDD--EESIVTLLQYNLERSG-YDVITASDGEALKK-ETEK--PDLIVLDVM---LDGIEVCKQLRKLMFPILMLTAEEFD-GADDYMT-----------KP-FSPREVN

                                                    DPILG-------------------------------------------------------------------------------------GV---------------GKPY--RA-IGTGSLRVGANFLQRFFKFSDVYLP-----KPS---T-----RD--QLQAYRY-FTGAMEDISKIPEKSIILLHACARQEQWKELASVVKKRNLLAYFDMADAWRHFIVVLSQSY

                                                                                                                                                                                           KVAIITG----LGIGLAIATKFVEEG-AKVMITG--QHD-KLFD----VSTLVNNAG--LAVNLDGVFFGTRLGIIINMSSIEGGAVMSVNTVHPGY--VD---GEPNDIAYICV

                               GSLVVLGS----GKGANQAVAAGRSGANIAFILSPALVEAQ-----------------------------------------------------------------------------------------------------------------------------------------------------------ERIANA---SALLMQLESPLESVMAAAKIAHQNKTIVALNPARELPLLVDIITPNET----IA--GDTFNGALIT-EA-------DA

                               ATVLIVGPNVGKSTLFN--VK-TVETFKLVDTC-GVFD---------EADLVLFVVDRGITKEDESLADFLTVDTILVAFVKPELYSLGFGEPIPV----------SAEH-NINLDTLEIKKLELDL-----------QG--ITRQDQRAG

                                                                                                                                               MTIIETP--------------------IRL----LNELPF--YSKICGVSIVRAGESMESGLRAVCR------VRIGKIL--YEKLPADIRERWVMLLDPMCAAGSVCKAIEVLLRLGVRIIFVNLAIERVYKVRMVTAAVGIGDF

                               IKCVVVGDAVGKTCLL------YSANLGLWDTAGQ----YDRLRSYPQTDVFLICFSL-SYENVRAWFPEVRTPIILVG-GLALAKEIDSVKYLE-----------CSARGLKTVFDE-LCP

                                                                                                                                                                                           KGVLVLA----ASIGRAVADVLSQ-EGAEVTICA--CDLFEKVKEV---DILVLNAG-LFLNMIKIVRNYLPAMGRIVAITSRMAGFL-VNCVAPG------WTE-PEEIASVVA---------------SEKA

                                RRVVSGGRGL----FAIIEELD--KLGAAVGASRQVGGK------VAPELYVAVGI-SGAIQHLAGMKDSKVIVAINKDEEAPIFQIADYGLVG--------------DLFSVVPELTGKL

                                                                                                                                                                                       KIIVKHVTVIG----GLMGAGIAQVAAATG-HTVVLVD--Q--TDAASVVHSTDLVVEAIVENLKVKNELFKRLDKFATIFASNTSSLQSIA-FAGLHF----------FNPVV---FLG--VPYLME-LHQPLN-LVA

                                                                                                                                                                                       TDKDHQKVILVGAVGSSYAFAM-GIAQ------EIGIVDIFAE---YSDAK-DADLVVITAPNLKILKSIVDPIVDSGFNLIFLVVDILATW-FRVVGSGT--TFGIATALARISKAILND

                              KKTIYFGAGWRQNKAYKEAMEALKENPTI-YVP-----------DN-------------------------------------------------QYKRVD-------------------------------HDKV------WATATYNN--------------------------------------------DL-NGIKTN---DIMLGVYIEEDVGLGMELGYALSQGKYVLLVIKPINLMVSDNVI-------------KMSQLKDFNNK

                                                                                                                                                                                           KKVLIVED--NELNMKLFHDLLEA-QGYETLQTREGSALSIARENK--PDLILMDIQ----SGLEVTKWLKLAHIPVVAVTA-ERIGGCEAYIS-----------KPIS--VVFL-----ER

                                                                                                                                                                                        FA-KVAIITG----SNGGRATAVLFAREG-AKVTITG--DVAGEILSTK--LDILVNNAG--LNLNLRSVIALTKKAVIVNISSIASAAIYTVNSISPGL-----VAGQPQDIAEVIA

                                                                                                                                                                                          SMKVVLVGGAVGSSYAFAM-----QQGIEEFVIV--DV---GEYSDCK-DADLVVIT--NLNILSSIVKPVVDSGFDGIFLVVDTYATW-FRVIGSGTDKAFGIGTALMRISKAILRD

                                MKITVIGAGGATTAFRLAEKQL---ARELVLLDVNDY-----ADTAN--SDIVIITNAIVKEVTDNIMKHSKNPIIIVLDTHVAWVRS-RVIGMAGHGD--GSAAPASSVVEMVESIVLD----RKRVLP

                               HAVVFTGAG-------YAIAELER-MGIVKAVI--------------------------------------------------------------------------------------------YYVK---FGE--PLPQRTLF------------------------------------------------EAIEEAKHC---DAFMVVGSSLVYPAAELPYIAKKAGAKMIIVNAEPTMAIFDVKIIGK----------AGEVLPKIVEEVKRLRSE

                                                                                                                               NR--------EAT-----------------------YLKY------GFIG-DPVVRRFG-GEAIILGR--A--L---IVKELMGM-GFMLFICD-FTQIVHAANYAQRIRAFVLYLGEHDMVKTAAAFGAIFTGFPVITDQPLPKQ--WFFSVED------------YDKIVQ-------KLTKIKLD-----LPIYV

                                                                                                                                                                                SAEDAA---NASKVIIVPGYGMA-QAQHALREMADVLKKEVSYA-IHPELEEINSSFTADVAFVIGA--ND-VTNP---DVEK-AGTVLFIKRSM--ELFTMMLFG----------DAKKMTEQIVQ

                              RKKLVIVGDACGKTCLLI-----VADELALWDTA--G----DRLRSYPDTDVILMCFSI--LENIPEWTPEVKVPIILVGPERDMANRIGAFGYME-----------CSKDGVREVFEM

                                                                                                                                                                     QHK--------EITRDLP---KKLGVIPILRAGIGMVDGILKLIP-----AAKVGHIG--YVKLPSDVEERDFIIVDPML--GSAVAAIDALKKGAKSIKFMCAGVKAVHDVDIYIAAGLGDA

    DKNT--------LL-LAYE----------------------------------------------------------------------------------------------------------------------------------------------------------TRHLKC----DIVVVPILRAGLVMADGILELLP-----NASVGHIGYA---KLPPLNDDKEVFLLDPMLGVSSIKAIEILKEGAKKITLVAIAVEAVYDVKIYVAA--GL

FK--AE--LN----PERR-AL-RIAHEANKGTLALVGIHTRGIPLAHRIARFIAEEGKEVPVGVLDTR------IPFDLKAIVLVDDVLGRT--ARAALDALPRRIYLAVVD-----IRA--DFVGKNV-VVKVKRV

                              LK----------GDYNLV----------------------------------------------AL-AFD------------LEMAKNITAA--AIY----------ACN--------ALF----------NDE-AS-ESLNAAVDETLKFIA--NRDKVAVLVGLRAEEAAVKFTDALG------GAVATMATSWSYVEKTMKEADAVIALA---VFNST---DIPDPK--KLVLAEP---------VVPSV-------KDYLTRLAQKVS----KK

                               EEFAVTGTD-GKTTTTAVAHVLKHLRKPVVYELDEFF-----------PNYLIITN---ARG---A-FEKINTDLVVTF-EDELTSHLGDVTFGVK--------GFHNVLNAL-VI-D---GYDLA---------------------------------------FR-GVHRRFS--DYAPFQP

                                KILVIGPSW---DSQSLYRTLQARPQAIIDVA-------------KRYDRAYVLP--NSFK-SALVPLFAGIPHRTGW--RGERYGLLNDVRVLDK--------L--VERYIALAYD---------PQ--------GEKS---YTCN----SSER-PIGFCPG----YHYAELAKQLID-EGYQVVLF------------AA----AIVTND----GLHVAAA-LN----RPLVALYSPDPPLSKARVIRLI--HQSLIDITPQRVLE

                                MKITVIGAGGATTAFRLAEKQL---ARELVLLDVNDY-----ADTAN--SDIVVITNAIVEVTGRIMEHSKNPIIVVVLDTHVAWQKS-RVIGMAG-----GSASPATSVVEMVESIVLD----RKRVL

                               YLVALTGAG------HQAFAELER-LGVLKCLIT----LDR------RADVIIVAGTSAVVQPAASLPLIVGGAIIEINPDETPLTPIADYSLRG--------------KAGEVMDELVRHVRK

                               VDLVFLFDGKILDFMKDVMKKLSNTSYQFAAVQF---SYKT--DF-AR-TKVLIIITD-GEA------IAAKDIIRYIIG-QETLHKFASFVKI--LDT-----FEKLKDLFTELQKKI---YVI

                              HVNVGTIGHVDH--GKTTLTAT-EYDHYAHVDCP-HAY--VKN--AAQMDGAILVVAADGPMPQTREHILLGRPYIIVFL-VEMEVRELLTPIVRG-----------SALK------------------GD-----------------------------------------------------------------------------------------------------------------------------------KILELAGFLD-----ERA

                                                                                                                                                                                        PD-LDVILLLDGYF----KSFAKAFISKANIQVSVLQYTT-F---RYLT--SKAVVILVTDVSVDVDAAADAARSNRVTVFPIGIDAAQLILANVVKLQR------IEDLPT-VT-FL

                                                                                                                                                                                         TGIEVAFAGRSNGKSSALNTLT--FEVADKRLVDLPGY--QRALGEYLE-LQGLVVLMDPLKDLDQQMIEWAVDSNIAVLVLLT-MVAV--DVQVET-----KKQ----VDKLRQKLDTW-FS

                                                                                                                                                                                            MRVLVTGGYIGSHTCVQLLQNG----HDVIILDDI--L-EILHDHA--IDTVIHF--NVNGTLRLISAMRAANVKNFIFSSKEQIL--WSIALLRYFNPV---V-LADGHVVA-EK

                                                                                                                                                                                           MRVGVLGKGKVGTTMVRAVAAA---DDLTLSAELDAGDPSLLTDGN--TEVVIDFT--HPDVVMGNLEFLIDNGIHAVVGTTGFTFQV-VLIAPN--HHPHKA---RTSFVP

                                                                                                                                                                                           KAVAINGY---GTVGKRVADAIAQQDDKVIGVSK--VAIPTVDDMLD-DIVIDCTP--EG-IGAKNLKMYKEKGIKAIFQGGEKHEDI-YTRVVSCNRRGAD

                                                                                                                                            FS-DDWA--RPL-----ILP------WSPKD-----VADP--ITFRMKTRFIIHGFIDKGWLSNICKNLFKVESVNCICVDVGEVA-YFVEYSPSNVHVIGHSL-----HGEAGRRT-GTIERITGLDPAE-RLDPVDVIHTD-----VA-LRSYKYYADSILN

                                                                                                                                                                                           KTALITG----RGIGRAFAEAYVREG-ARVAIAD--ALD-RCVAE---IDILVNNA---FAINVSGTLFMMQAVAIINMASQAGAAVLTVNAIAPGV-----VDGRAEDLTGMAI

                                                                                                                                                                        RGTTEGNLVANSWGNSNVRDNIIISQMHA----NIV-WQM-CAR-GAELRVIP-LQL-ETLPTLFDEKTRLLAITHV---PLAEMITLAHQHGAKVLVDGA-VDVLDCDFYVFSG-HK----------------LSQLESVPLTLYFNL-TGHHC

                                                                                                                                                                                             MKVAVGQALALLLKT--QLPSG-----SELSLYDFDATPALEGA----DVVLIS--AGGIVKNLVQQVAKTPKACIGII-VNTTAA-LFGVTTL-DATLSMGQAAARFGLSLVRALQGE

                                                                                                                                                                        SGMCASTVMLLALV---P-GHIVTT-----TDCYRKTRET--PKMGITATVIDPADVGA-LELAL--KVNLFFTESP---DIELVSKLCHEKGALVCIDGTTPKALGADLVLHSAGGAVS

                                                                                                                                                                                           KIIYFLCNSCRSQMAEGWAKQYLG--DEWKVYSAGIIIDSDILNNA---DLVVTLCGD----ADKC--PMTPPHVKREHWGF---------------AQ-FRVRDEIGNRLKEFAETG

                                                                                                                                                                                           KVALVSG----RGMGASHVRAMVAEG-AKVVFGD--ILD---WAAV--LHVLVNN----LDVNLTGVFLGIRAVVIINISSIEGFAVLTVNSIHPGL-MTD---AEPVEVSNLVV

                                                                                                                                                                                           WKIAVVDD--DKNILKKVSEKLQ-QL-GRVKTFLTGEDFLND-EEAF--HVVVLDV----YSGYEICRI-KETETWVILLTLLSSVAGADDYVTK----------PF--NPEILL-----LE

                                                                                                                                                                                           PHFLILNGPNVNRL-LTIETDLFQFAEQLTFFQS-GDLID-AIEAE--SGIVLNPGA-SHYS-YAIRDAVSSISLPVVEVHRHQSVIVAKGQIVG----------LGAEGYKLAV

DFP--VLKDPASF----GLL------------------------------------------------------------------------------------------------------------------------------------------------------------HLKATHG--RIDYIAGLDSR-GFLFGPSLAQELG----LGCVL--IRK-LEIQKDALPGQRVVVVDDLLATGTMNAACELLGRLQAEVCVSLVE-REKLPVPFFSLLQ

                                                                                                                                                                                           KTIAVVN----GRQAASLIRVAAAV-GHHVRAQV-L--PLTLFEGA---HLAFINTTSEIAIGKDLADAAKRAGTIYIYSSMKFTNYVRPSTFVY-AGIYNWL-----DVGPALL

                                                                                                                                                                                      QRR--KKVAMIGS---GMIGGTMGYLCALRELADVVLYD-VYSY-AALTGA---DCVIVTAGLNSKIIREIGQNIKKYKTFIIVVTNPCMKVMCICGMA----GSAAPAASAVAMATSFLND

                               PLVVTTI-----GMIADAVKIAQGDVHLKGLMVDP-YT--AT--GDEWLGLILYNG--LHL--ETKMGEV-KLRVVAVSE-------------TIP-QRL--FDVKLWSYSVKAVYESLCKLLPG-TR------------------------------------------------------------------------------------------------------------------------------QRYQAYQQQLDKLDAY

                                                                                                                                                    KPWAGRPIKSLPSDP-------TATDIATIK----FNLNKTRFIIHGTD-GEWLSDMCKNMFQVEKVNCICVD-VEVA-YLVQLSPENVHIIGHS------HGEAGKRL-GLVGRITGLDPAE--LDPVDVIHTD-IS-----HRSIEYYHSSIL

                                                                                                                                                                                           KKISIIG----GFVGSTTAHWLAAKELGDIVLLD-IV--TNNYADTANSDVIVVTSGVNADITRACISQAAPLSAVIIMVNNPDAYLAAVIGQA-G--GGAAPAAATAQMVEAVLKD

                                                                                                                                              TES----------------------PETLKAIDFLYAM---SPAP-THILGFDARGFLFGPMIAVELE------IPFVLMRK-TIR-YGSIGKGSRVVLIDDVLGGTALSGLQLVEASDAVVEMVSLS-AA---IKFISLLSD

                                                                                                                                                                                           VNVAVNGY---GTIGKRVADAIIKQPDKLVGVAK--YVPQTVEDLIK-DIVVDTTP--NG-VGAQYKPIYLQLQRNAIFQGGEKAEVA-YIRVVSCNRRAAD

                                                                                      VKDE-------------------YA-------------LTTR----------------------------------------TGPTALH------RRL-GWHQALVLYADPCFFIVEGLYMRVRERLNITVNHQEFVKLL--AVRKG---RVIYICSSPDA-NLMLLAL--LT-DYVFFHLDQSLPWFQAAKIITYGLK----------------LYVQAVTET-NITQR

             VGDI---------------PIVAITGSNGKSTVTTLVGEMAKAA-LVLELSSFQLETT--------AVAATILNV---RAAKLRIY-ENAKVCVVN-ADDALTMP--CVSFGV------------HNYTNALA---L---PRA--------------------------------------------TGL--PHRDSKAT

                                                                                                                                                               FDNNAT-TS-CATESNWILKTVAETFEKRTIITT------PIE--L---M-KYLSKVKYVPV--VKLEELEKLVDEDTLVSIMAAIQ--PVEDVTRIVKKKNTLVHVDAVFSLELEVDYASFSA--HK----GIT

                                                                                                                                                                                       RFTDRVVLITG----GSGGRATAVRLAAEG-AKLSLVD--VAD-AYVTT---IDGFFNN--E-VSINLRGVFLGLEKVLVVNTASVGGHGVLTINAIAPGA-----WTGEAPEIAAVVA

                                                                                                                                                                                           MKILVIQGPNLN-L-DQIHEIMQTFVDVELEFFQTGEIID-KIQESV--EGIIINPGASHTS-IAIADAIMLAGKPVIEVHNIKNSYACGGVIMG----------FGPLGYNMALMAKAFQEA

                                                                                                                                                               LDYSATT--SGATES--LAKGAANFYQGKHIITS-----KTEVL-----C-RQLEEVTYLAP-IIDLKELEAAMRDDTLVSIMHVVQ--DIAAIGEMCRARGIIYHVDASVIDLLKVDLMSFSG--HK------------------IKDIEEVYLVSF

                                                                                                                                                                                            CPAAVITGRIGHSIAVRLHQQG------FRVVVH-CII-CSFRGR---CDVLVNN--NAVAPLFLIRAFARRQ-LSVVNLCLGGLTAAIRVNAVAPGL-SL-AAQIADAIAF

                                                                                                                                                                                           DTIALVVSTL-FVSLKDGAQKEADKLGYNLVVLDSENVQ-DLTVRGT--KILLINPTRSDA-VGNAVKMANQANIPVITLDRQ-TKGEVVSHIAS------IKPDQIGAKG-ET

                                                                                                                                                                                      ASL--KVALVTG----RGIGREMAMELGR-RGCKVIVNYAN--RMEEAVGKL--DIVCSNSGINTRGQFFVAREAYKHLGRLILMGSKGATFA-VNVVAPGG---MY--GLPIDIARVVC

                                                                                                                                          LSTPAA---------------------------KE--AHYKDVP----ITKVVGIESR-GFILGGIVANSLG-----VGFVA-LRK-IEVQKRQLGPHDVVLLHDDVLGGTLLAAIELCETAGVIYINVLYE-GRVKCTRLFSVIRE

                               KQFAVIGLGRF---GGSIVKELHRMGHEVLAVDAT--ENELLSLGIRNFEYVIVAIGA--IQASTLTTLLLKPNIWVKAQNYYH-HKGADRIIHPE---------------------------------KI-----AQSL

                                                                                                                                                                                           KVWLITGV---GFIGSNLLETLLKL-DQKVVGLD-I--DDNACAGV---DYVLHQAALNIDGFLNMLIAARDAKVQSFTYAAKYELYASTIGLRYF------NVF--ENTVQ

   PCL--VYSARVNMGTKL-------------------------------------------------------------------------------------------------------------------------------------------------------EKIRE-WEDLD----I-DVVIPIPETSCDIALEIARILG------PYRQ-GFVNA--NRAEFRDKNVLLVDDSIVRTTSEQIIEMAREGAKKVYLASPEEIIIGADGLIFQDL---LI

                                                                                                                                    TPYQSA---R---------------VW-L--NEY-----RGADEG---LLR-AFCEDAILYC----PPT--GYS-VSAETIGVECRTVPLDGIS-DKLDGV---KVVYVCSPLINPQDFRTLLELTRGKAIVVADEYASLAWYLAILR-TKTNYIL-----TREESQRVIDALRAEQV

                                                                                                                                   RNK--------------------------EKP-----TDIQKVIPLFLND--E----EAIILTPTELAIQVADE-IE--K-KNLNIVVGTPGRILDHI-LNLK-VKYFILDEDELN-GFIKDVEKILNACNRILLFSATPLNLA------KI------QNPESYHRIGRTG----------RAGK

                               AKVAVLG----GGIGQPLSLLLKNSPLVLTLYD----PEQL----LKGCDVVVIPAG--NATIVATLTAACAAMICIISNPVNSTIPIT-------------------------------KKHGVYNPN--------------------------------------------------------------------------------------------------------------------IFGVTTL-AATLSMAYAGARFVFSLVDAMNGK

                                                                                                                                                                                  PSTIG-FQTKTRFIIHGFI--NWLLDMCKNMFKVEEVNCICVD-V--AQQMLSLSPSQVQLIGHS--AH---GEAGSRT-PGLGRITGLDPVE--LDPVDVIHTD--FVAC--LRSYKYYSESILN

                                                                                                                                                                                           MRVLLSVCRGDVEIGVALADRLKA-LGVQTRMCA--VAV-GAAEGC---AAVVAVG--DLAAATGVRSVAEKLGLPFFYSVPYLFGYGGERPLLAA---------AWLESLSAA----LTT

                                                                                                                                                                            SGMGAIAATVLTIL-DHLISD-ECLY---HAL----FEHALTQVDFINTAIPGE---KHMKPNTKIVYFETP----DMERVCKDAHSQEVLVIADNCTNPVFGVDVVVHSAGSMIT

                                                                                                                                                                                           MRVLLATCRGDTEPLVALAVRVRDLG-ADVRMCA--V-I-AAAEGC---AAVVTTG--LLAAAIGVRSVAEKLGIPYFYAFHYVFTFG--HPWVA----------AWI-SLSAA----LTPHAR

                                                                  SL--DRVAAA-----------CE--------------------------------------------------------YAA-PVAR-------LSAGRVAP----KMGEMMLALFRHHWSRAALVYSDDRNCYF--EGHEVF-QEEGHTSIYSF----LEDIVRNIQ-ERVVIMCA--SSDTIRSIMLVA-GMDYAFFNIESS-DGSYLQTVTL--NMF-------------------VLRAGYSKKD

                                                                                                                                                                                           KVVVIDAKTFNLAMALKVESILKQNPKLEVVLTR--FLE-QRVKVAE-NVFVSIHANS--------FHVIRETTMPAVLLEVG--------------KEEATLFFRVAQGIADGITE---YLDVK

                                                                                                                                                                                                     AH-ALAKLQDA-L------RFLLVTHMEIYMALSMA---DIFIAIGTSGHVYAAGFVHEAKLHGAHTVELNLEPS-QEFAEKYYGP------ASQVVPEFVEKLLKGLK

                                                                                                                                  LL-----DALFG------VDL-----GKPW--------LSGTGAHISAKFFSKFFPDKLVYLS-----KPT--NHMAI---EQGKTATYPY-LGFL-NAIQKAPEGSIFVLHSCATSEQWVQIVDAIASKNHIALFDTYQ-VRLGVVFVCQSFKN

                               VNVGTIGHVDGKTTLTA---T-EYEHYSHVDC---PGHADY----AAQMDGAILVVSDGPMPQTREHILLARPYIVVFM-VEMEVRDLLVPVIRG-----------SALL-----------------RRGEN---------------------------------------------------------------------------------------------------------------------------EW-----KIWELLDA------TP

     LAG--HRRILTLLHALGN-----------YIHVT-GKGSAANAIAHVLEAS--DVAVIEVDSTN------------VVSVLTEV----HKAGII--KRGIPVVTGNLAAVVAAKVSQWLRFDVP----DYQQRNMAIAIQTAKV-AKQTEWPL-TPQNIRQGLAAS------KIS----PLI

  QKAV--ILQAIRRALTRIAHEMIE--RNK-CILVGIKTRGIYLAKRLAERIEQIGNPVTVGEID---GAD--IPVDIQKVILVDDVLGRT--VRAGMDALPSSIQLAVDRGR---IRA--DYIGKNI-KVMVQLV

                                                                                                                                   IEAI-----KTLRF----------------------TEIQERIIPGALRG----IK-QAVITAPTELATQIYHETL----ITK-HIVIGTPGRINDFI-ALDVHTAILVVDEADLLDGFITDVDQIAARPDL-LVFSATIKPFL-PTFVHVL

RCIRT--DMSLK--PNDA-SEKEVIDTILLI-PVILADA--CCSVKAE-TKKLIDLTQFPAFVTP-YVGTLSKEVAV-SADLILSAL------LSDF---SYKTNIVEFH-DH------RNAT-PG--------------QMKFVLQKLLTAIAD----------------------------------------GT------------------------FT--------------------GDLQLT--------------------HLSLL

                              VKLVAVIT---GGASGLATAERLVGQGASAVLLDV-DVQT-LA-LAKGRVDVAVNCAGI-NLMGTFNVIRLVAGVIINTASV-GGIVGMTVMTIAPG-------------D-PAEYAHL

                                                                                                                                                                         GEGV-KEV-----PPL-AGPAALLFDRRVEGAQ---AK--GV-----RHLLGL-KVL-SWLAGLPRNATLLVVGGGT---TDLGGFVAATYGVAYLAFPTIVDA-FPQGVYAELLKTL

                                                                                                           VNA------------KAL-------------------ALTA------------PDF--------VGGSQALFNLF--AILDEVIVL-----SPY---YPE-VR-FAGGVVVEVEPDRVR-RAITPT---KALVVNSPYPKEVLEALARLAVEHDFYLVSDEYEHFSPGHTLTVNGAKAFYV-----SEENLRKALERFARVL

                                                                                                                                                                                           KQRVFIAGGMVGSAIRRQLEQRG---DVELVLRT--L-V--FFSER---IDQVYLAAKNMMIESNIIHAAHQNDVNKLLFLGSIIKLC-DYRSVMPTN---LYVDMAAASI

                                                                                                                                                                                           KVALVTG----QGIGKAIALRLVK-DGFAVAIAD--YVD--AVEQ---FDVIVNN----YNINVKGVIWGIQAAVIINACSQAGFAVLTVNGYCPGI-----VKLSPEDVAACVS

                                                                                                                                                                                         AFAHFVLIHTCH-AWIWHKLKPLLE-ALGHKVTALDLEPLLT-FLAL-EK-VILVGESC---LNIAIAADKYCEKIAAAVFHNSVLPD---KIYVWTDEI------KLQLT-TKEIA--YN

                                                                                                                                                                                        MSNLKVLVMDE--NGVSRMVTKGLLVH-LGCEVTTVSSNEEC-RVVSEH--KVVFMDVCMP--VENYQIALRIHEFRPLLVALSGNS-KFGLDGVLL------------KP-VSLDNIR

                                                                                                                                                                                           AKIVLVGS---GMIGGVMATLIVQKNLGDVVMFD-IV---NTYDDLKDADVVIVTAGLNNKIMIEIGGHIKNNCAFIIVVTNPDVQLLHKIVGLG--DTAPAPAAAIIEMAESYIRD

                                                                                                                                                                                           ATILLIDD--HPMLRTGVKQLISMAPDITVGEASNGQGIE-LAESLD-PDLILLDLN--MN-GLETLDKLREKSLRIVVFSVSDTA-RGADGY------------KDMEDLLKALHQ

                                                                                     SD-----------AK-SPS----------------------------------------KLSTL-------NLLT-------------LCMA----TA--ICDYALVP-----PGF--PHYETVCKAYGIGMHFYNCEADLDEIRRLKDDTKLLIVTNPNFRKHVEDIVRLAEELRLPLFSDEYATSVA--RVILGGT----AK----PVEVYREAVERIKAFCQ

ITAK------IAL--------------------------------------------------------------------------------------------------------------------LH---------PQI------GFF---DIPI---------HL---VPIYFEGKN---LEDIVIVS----GVTRARKLADRLK----A-PIAI--ID-MNIV--NIEGKTAILIDDIIDTGTITLAANALVENKEVYACCTHP---INIKELVVTNSI--------VGPLLAE

                                                                                                                                                                                           TVPVALVTGRLGRSIAEGLHAEG------YAVCLH-VLV-ACYTGR---CDVLVNN--NAIAPYFLIKAFAHRV-YSIINMVLEGL-AAIRVNGVGPGL-SV-AAEVSDVVIF

                                                                                                                                                                                           KVALTTG----RGIGRGIAIELGRRG-ASVVVNYG-QAD-ALFDK---DFVMSNSG-E-FNLNTRGQFFVAQQGLIILTSSIAAKAAVEVNCIAPGGSW-----GYPADIGRAVSA

                                                                                                                                                                                           PSVFLIDD--DRDLRKAMQQTLELAG-FTVSSFASAEALAG----LSAAGIVISDIR---MDGLALFRKILALDLPMILVTGHGMA--AYDFIAKP------------FAADRLVQ-ARNRSL

                             LFRRVLVTG----KGIGRGTVQALHATGARVVAVSLG-TERALGS--VGPV-----------------------------------------------------------------------------------------------------------------------------------------------------------DLLVNNAA---FEVNLRAVIQVSQIVAIVNVSSQCSGALLTVNAVNPTV--GQ---AEVEHVVNAIL---------------SDRS

                                                                                                                                                                                           KRVFVTG----GFKGGWLSLWLQT-MGATVKGYS--GDES--REFQP--EIVFHMAAQNVMGTVYLLEAIRHVGKAVVNITSKGCLVT-VATVRAG--NVA------LEPLSGYL

                                                                                                                                     MGIFEMWE----KP--------------------SPIQEESIPIALSG----KDNQAMVIVPTELALQVSIC--S---MGGAHVVIATPGRILDLI-VAKVDHVQMIVLDEKLLSFV-QIMEDIILTLPQILLYSATFQKFSHL

                                                                                                                                                                                           EKVLVTG----GAIGSHTVLELLEAG-YLPVVID--MDALRLFKKYS--FMAVIHF--NLTGTIQLLEIMKAHGVKNLVFSSKFEEMI-NAVLLRYFN-PT---V-LAKGHIA

                                                                                                                                                                                           MRVLVCG----GYIGSHFVRALLRDTNHSVVIVD-DV-FLGVFTHGP--DAVVHMCA-NVVGILRLLQAMLLHKCDKIIFSSKLIRMIIGICLRYF--NATH-VCDLASAHILA

                                                                                                                                                                LK-PW--PENT-----VADP--IQFNTKTRFIIHG-I--SWLSTMCQNMFKVESVNCICVD-VEVA-YLVGLQPSNVHIIGHSL-SH---GEAGRRT-GAVGRITGLDPAE--LDPVDVIHTD-AA-----LRSYKYYTDSIL

             FVQGKLF--SV----EREIDVVMTVATKGIPLAYAAASYLN-----VPVVIVR--SLAKRS--MKTSNVLIIDDFMKA-GTINGMINLLNVAGIGVLVEGV---LVDEYMSLLT-LSTI