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MKTLIEIKQTPDGIIKADKVFNKVKDKISLPNRILYLGCGSSHFLSKLLAMVTNMHGGLGIALPCSEFLYSKETYPIGEVELAVGISRSGETTEILLALEKINVKKLGITTRESSLTRMCDYSLVVPAIEESVVMTHSFTSFYFAYLQLLRYSYGLPPLNAGEISKATEKSLEYERYIREIVESFDFQNIIFLGSGLLYPVALEASLKMKEMSIFWSEAYPTFEVRHGFKAIADEKTLVVLMVEEPFEWHEKLVKEFKNQGAKVLVISNSPQDLGQDYSIELPRLSKDANPIPYLPIVQLLSYYKAVSRGLNPDNPRFLDKVVRW

HYMQKEIYEQPNAIKNTLT--R--LSLADKVEHIQILACGTSYNSGMVSRYWFESLGIPCDVEIASEFRYRKS---VRRNSLMITLSQSGETADTLAGLRLSKLGSLAICNVPSSLVRESDLALMTNAGEIGVASTKAFTTQLTVLLMLVAKLSKEHVHGLQALPSRIEQMLSQDKRIEALAEDFSKHHALFLGRGDQYPIALEGALKLKEISYIHAEAYAAGELKHGPLALIDADMPVIVVAPNLE-KLKSNIEEVRARGGQLYVFADQDAGFVMHIIEMPHVE-EVIAPIFYTVPLQLLAYHVALIKGTDVDQPRNLAKSVTV

PG--LGWVDWPI--RYDKNEFS------RISDALVVIGIGGSYLGARA--------TTQIYFAGQNI--STISHL--DVLE-INV-ISKGTTTEPAIAFRIFRYMIYVTTDRTGALKK-------FVIPIG---GRY-SVLVGLLPIAVAG-------LNIDRMMEGAASAYKY-NESYQYAAVRILYIELLVNEPSLHYVSEWWKQLFGESEGLFPASVDFTTDLHSMGQYVR-LIETVLHV-K-EVNKKAFQGTLLAHVPNLIVELDE----------------MNETFGEMVYFFEKACGISGHLLGVNPFDQPGVE

IN--AVL--HVALRPEVNKVLDK-A---RVITDVINIGIGGSDLGPLM--T---SSGPRVWFVSNID--GTIAKT-CLNPSLFIIASKTFTTQETITNAKTAKFHFVALSTNTAKVKEFGINMFEFWDWVG---GRYSLWSAIGL--AL-G--------NFEQS-HWMDQ-FRP-VLLAMLGIWYICETQAVLPQY-LHRFAAYFQQGDMESNGPIVWGEPGTNGQHAFYQLI--MIPCDFLIPV-LANFLAQTEALMKGNRPTNSIVFT----------------LTPILGALIAMYEHKIFVQ------NSFDQ-GVE

                                                                                                                                                              EILNELHNSAAY--ISNEEADQLAD-HSSHQIFTAGAGRSGLMAKSFAMRLMH-MGFNAHIVG-------TPP-LAEGDLVIIGSGSGEKSLIHTAAKAKSLHGIVAALTINPEGKQADLIIRMPG-MGSLFEQTLLLFYDAVILKLMEKKGLDSETMF-----ANL

                                                                                                                                                              KEWQEHQKIVQAS-ELKGQIAKVGELECLGKILICGNGGSAADAQHFAAELSGRKALAGIALT-FVFSRQVEALGNEKDVLIGISTSGK-PVLEALKKAKELNLCLGLSGKGGGNKLCDHNLVVPSDDTARIQE-HILIIHTLCQIIDESF

    EELDIVSNNILILKKF-KNKLDSLRIAKKIFIFGVGRSGYIGRCFAMRLMHLGFKSYFVG----------TTTPSYDLLILISGSGRTESVLTVAKKAKNNIIAIV--EGNVVEFADLTIPLEVKKSLPMGTTFEETALIFLDLVIAEI--MK--------------------------------------------------------------------------------------------------------------------------------------------------------LNLDESE-IK---NL

                                                                                                                                                                     ANT-HL---LVLAARIIAAIPEDVVAISSRTFGQRAVLKFAAHT-----GATPIAG--RFTPGSFYKEP--RLVIVTD-PRS--DAQAIKEASYVNIPVIALTDLSPSEFVDVAIPCN------GKHSIGLIWYLLAREVLRLRGALVD

                                                                                                                                                                 PDDAAGV----ILDERIRVAAKFLRYEPILLVAARQYAHKPVQFSKVV-----GSDYIVGRFI-GTSEYREPE---VVFVND--A---DKQAVSEATAVGIPVVALCDNNSSADVDLVIPTN------GRRALAIVYWLLAREIAKIRGQDFT------ELEG

                                                                                                                                                                        GVH---FNEALAELNKIAGKILFVGTKRAASEAVKDAALSC-----DQFFVNH--RWLGGMLGLP---DALFVID--DH---HIAIKEANNLGIPVFAIVDTSDPDGVDFVIPGN------AIRAVTLYLGAVAATVREGRSQDLA

                                                                                                                                                                     AGV------LERTFRFIEDLAGTILFVGTKKQAQDIVRMEAERAG-----MPYVNQ-RWLGG-MLFRLP--DAIFVVD--TK--EAIAVREARKLFIPVIALADTSDPDLVDYIIPGND-----AIRSIQLILSRAVDLIIQARGGVVE

                              AKITVVGCGGAGNNTITRLKGIEG-----AKTVAII--SAEI-----------------------------------------------------------------------------------------------------------------------------------------------------------AAIQDS---DMVFITCGLGTGSAPVVAEISKKIGALTVAVVTLLERLHTDTLVVIPNEAFKVADEVLINAVKGLVELITINV

                              AVIKVIGVGGGGGNAVN-MA----NVEG-VEFICANVLRERI-----------------------------------------------------------------------------------------------------------------------------------------------------------EVLEGA---DMVFITTGMGTGAAPIIAEVAKEMGILTVAVVTR-IRASVDSLITIPN-AFAKADDVLAGAVRGISDIIRPDF

                                                                                                                                                FCI---PNHYAE------PHGLIMDRTERLARDVMKEMGGHHI--VALCVLKGGYK-FA-----IP----MTVDFIRLVIGG-DDLSTLTGKNVLIVEDIIDTKTMQTLLSLVRQYNPVKVASLLV-YK----DFVGF-EIFVVGYA

                                                                                                                                                                       LLPL-----GLREAAA-LEAKRIRVHGDYDGLTGTAILVRGLAALGADVHPFIPVL-RVPEHLEASD--LFLTVDC--I---TNHAELRELLEVEVIVTDHHTPGTPPPGLVVHP-KP-------TGAGVAFLLLWALHERLGLPP-SSWVGLRLA

                                RLVGVTGTN---GKTTTTQLLAQWSSFCAEVSSHGLVQHR-----LKFAASVFTNLS--EAAW-LLYSEHHCGQAIINADDRRWLAKLDAVAVSE-----------FNVSNLLLALA---GYPDLL---AR--------RLHCAGKL

                                                                                                                                                          KHTVE---PEAEIKARIAELGRQITERYKDSGSDMVLVGLLRGS-FMMADLCREVQ----SHEVDFMTA---KDLDEDIRGKDVLIVEDIIDGNTLSKVREILSLREPLAICTLLDVN-VPV--EFIGFSI-VVGYGLP

     DQIPVHTLERAMREYYANIVNPYAP-----------------------------------------------------------------------------------------------------------------------------------------------------------PTNKVVIFYDHSTEKMARVLAESFRDE-GCTVKLMWCKACH-QIMSEISDGAVIVGSPTHILPYVAGTLQYIKGLRPIGGAFGSGE-VLWLT--PVKVKN----VPT--YEQLKTMAQTIARLK

                                                                                                                                                FL----VPPHKP-KIL--PGGLVKDRVEKLAYDIHRTYF--EE-LHIICILKGSRGFFN---------P--FEHYVRLVLS--DDLSIFRDKHVLIVEDIVDGFTLTEFGERLKAVGPMRIATLVE-SLK----DFVGFSI-VGC

                                                                                                                                   VDLKYT----EW---VDK---------SSFPVMNYGTYLR---TVGA--EF---ANKVQVVNLG--CGSD--LRMLPLLQMFPHLAYVDIDL-TTRLLDVTKREIPTIVISECLLNNESQLLINTIMSKSHGLWISYDPIASRW

                                                                                                                                                FM----IPAH-YK-----PNGVIKNRIEKLAYDIKKVYNNEEF--HILCLLKGSRGFFT------SR-KPLGEHYVRVIVS--EDLSCLKGKHVLIVEDIIDGKTLVKFCEYLKKIKTVAIACLFI-FK----DFVGF-SIFVVGYS

                                                                                                                                                                             NLDNAIDMI---EANSIIITPGCKAQYPIADLVKMLTE-QGKKVRFG--IHEMDEINHDFPDTDLVLVIG--ANDTVNS---EVWK-SKQVIVMKRSLG-IF-TAMLLGD-------KKTCDALQAK----VRE

                                NIIVFYGGTAEEFANRLSKDAHRYGMRGMSADPEEYD--------ID-SLVVFCMAT-PTDNAQDF-----VKFAVFGLNAMYVDQRLER-ELGLGDD------NLEEDFITWREQFWPAVCE--------------------------------------------------------------------------------------------------------------------------------------------------------FGVEATGE-----SSIVH

                                                                                                                                                                                           MKVTIIGSGRVGSATALLLAK--EPFMKDLVLIG--RSDEN-LRIID-ESDVVIITGTNAKIVGKYAKKIAEICDTKIFVIVDVMYKALQVFGLGT-GEQIGSEGPAAAILNVVR

                                                                                                                                                FF-----RNDVVK-----TFEECKALAADTARRMNEYYKDVAPV-TLVALLTGAY----LYA-----TF--TLHFVKVS-FDEEDLKQLEKREVVLIDEYVDSHTIFSIQEQIK---HAKICSCFVKDV-LTKMFYGY-PM-IGF

YQT---LPE----------PDVQAVTRLTLL----------------------------------------------------------------------------------------------------------------------------------------------------------AERPLIYYGIRKAGKELEQLSKTLK------IPLMSTYSANQKPANELAQADVVLFVG-----NY-PFAEKAFK-NTRFLQIDIDPAKRHKTDIAVLA------DAQKTLAAIL---AQVS------ERES

                                                                                                                                                           MDD-ERVNQDDIQKRIRELAAELTEFYE--KNPVMICVLT-GAV----FFYTD-LKDFQLEPDYIICS--ISKDLKNIEGRHVLVVEDIIDTLTMYQLLNNLQMRKPLKVCTLCDKADVPI-DYCGFVVEYIIGYG

                                                                                                                                                   YEFA------KI---TEEEIRTRIKEVAKRIADDYKGKG-NPVLISVLKGS-FMTADLCRALCDNV-PVRMEFICV--LDTR-HSIEGHHVLIVEDIVNALTLNYLYHMYFTRRPLKTVVLLD-PFS---DYVVA-NI-VIGYG

                                                                                                                                                                                           RECISIHGVQIGNA---CWELY--LETIDD-AVFV-IVLDRIRKLA-GLQGFSVFHSFGSGFTSLLMERLSVDYKSKLEFSIY-LTTTHSDCAFMVDNTYTNLNLIGQIVSSITASLRFD---GA

AFR---GAP--QM--GA--APDDAIDQVKLIA---------------------------------------------------------------------------------------------------------------------------------------------------------QAKNPIFLLASQ---ALRRLLETSH------IPVTSTYRVGQAGDRLLQLADLVICIG---SPVE-EP-AMWNS-NATLVHIDVLPAYEYTPDVELVGD-----IAGTLNKLAQN--------IDH

                                                                                                                                                                                           KKILLLNGPNLNTL-SDIEQHLQQSAQYELDYFQA-SLIN-RIHQAF-TDFIIINPGATHTS-VAIRDALLAVSIPFIEVHVRHHSYVAKGVICG----------LGAKGYDYALD--ISELQ

    PIFRNPGLF----DAFKL----------------------------------------------------------------------------------------------------------------------------------------------------------HLEEAFPEVKI-DYIVGLESRGFLFGPTLALALG-----VGFVP-VRK--EIQKNAIAGSNVIIVDDIIATGSAAAAGELVEQLEANLYNFVME-RSKLNAPVFTLL

                               PKALIVYGSNTEYTAETIARQLANAGYEVDSRDAASVE---------GFDLVLLGCST-LQDDFIPL--------------------------------------------------------------------------------------------------------------------------------------------------------FDSLEETGA-GRKVACFGCCGDAIKLKDGLRIDG-----DPR--RDDIVGWAHDVRGAI

           AARKSL-----VL--PLLPAPKILVAGS--HADTILEAVKAAV-DPTVVVFAEN--PDEF-KS---GGFSYAIVAVGE-IPEPGLSTVQAVGVRCATVLIPVVPLLAASDALVAAW----------LPG--QGVTDALFGD

                                                                                                                                                                         DFG------KDLISDCSSTTYVLVTDTNIGSYTPSFEEAFRKRAAPRLLIYNR--IEDWMLSPCGRDTVVIALGGGV--IGDLTGFVASTYGVRYVQVPLLDSKTQPTKIYIDLLETL------------------RHLGILKGVA

                                                                                                             LMG---EF--DPR-------------------VGV------------TGHTPIMFQKA-VGGTGARQALELARMANPDLRVFVS-----PTW---HVSIM-NFMGLPVQTYRYFEGMKADLAAAKKGDMVLLHGCCTLDQWAEIASILEKTGALPLIDLYQATRLIAVLIAASCSK

                                                                                                                                                                                           DTLLILGD-SLAG---AWPALLNDKWSTSVVNASGLARLPALLKQP---RWVLVELGGTEQTLRQILQDVKAANAEPLLMQISAIYLAVPLLPF-FM---DGIHP---FIADWMAK

                                                                                                                                                                                           INALTIAGTDGIQADLKTFSALG----AYGCSVITVQLD-SVFSDV---DTTKIGM-AETDIVEAVAERLQRHHVRVVLDTVM-LRLPQVSLITPN-------GTGCTLSAALAAL--RHR----HFHAW

                                                                                                                                                              TSRAQ-----EFVMQSINKA--DL---LAKKPVLYVGILGPRLLKELSDRAQ------IPVTTTLMLGCAANLAVQNADLIIAVGARFDDR---VT---FAPEAGIIHFEVSPKKVVQTQIAVEGD-----ATTNLGKMMSKIF----------PVK

                                                                                                                                                                                           KKILIVDD--EKPISDIIKFNMTKEG-YEVVTAFNGEALEQ-EAEQ--PDIIILDLM---IDGLEVAKTIRTSSVPILMLSAKFDIGGADDYVTK----------P--FSNRELQA

                                                                                                                                                                                           TTVYLAG----DSTMAGWGEYLASYLSATVVNDAYTGRFENIADVVTAGDYVIVEFG-FPAYLENAAKLFTAKGAKVILSSVEELAAAGVEYVDHW-VNYFAGAE-VAEAFLK----LTT

                                                                                                                                                                                          GKRVLIVDDAFMRMMLKDIITKAG----YEVAGEATNEAVEKYKELK---DIVTMDITMPEMNGIDAIKEIMKIDAKIIVCSAQQAMEAIKDFIVK---------PFQPSRVVEAL

                             SLKVALVTG----AGIGREMAMELGRRGCKVIVNYNVDIVRMFEEAIFGKLDIVCSNS---NTRGQFFVAREAYGRLILMGSI-GAIETFAVNVVAPGG------------------------------------------MYHA---------------------------------------------------------------------------------------------------------------------GLPIDIARVVC

                             RLKVAIIT----GGTIGLAIATKFVEEGAKVMITGS-GWTKLFDATE-GPVSTLVNNAG--NLDGVFFGTRLGIASIINMSSEGGAVRIMSVNTVHPGY---------------------------------IK-------LVDDLP-------------------------------------------------------------------------------------------------------------------GEPNDIAYICV

                                                                                                                                                                                         SKIRVLSVDDS--ALMRQIMTEIINSHSDMEMVATAPDVARDLIKKFNP--DVLTLDVEMPRMDGLDFLEKLMLRPMPVVMVSSGSERALGAIDFTKP------QLGI--AYSEMIA

                                                                                                                                                                 HV--SSS-VR-LNDQDLDILVKA-SASPAIVLGP--VD---NADCVMLA---RLKAPVWVAPLMP-AILL--GHDVVLVIGA------PVF---Y--LKGTRLISVTCDPLARAGDAIVAD-----------IGAMASALANLVE-ES

                                                                                                                                                                                           LIVNVINGPNLGH---ELVALIEREAALKAVVRQSAQLLD-WIHQAAAEPVILNAGG-THTS-VALRDACAELSAPLIEVHVRRHSYIATGVIVG----------LGIQGYLLALRY

                                                                                                                                                                                         QFKNIIVTGGA--GFIGSNFVHYVYNNHPDVHVTVLDILV--KLAAKA---DAIVHYAAENFIGTYTLLEAARKYDIRFHHVSTKAALIV-ATISNCSNNY-EK-----NDHSTGVW

                               LQVLVLNPPG---VSDALVLQLIRIGCSVRQCWPP-PEA------DVPVDVVFTSI--FQNRHHDEIAALLATTLVALVEYLSQIIELECHGVIT--------------QPLD--AHRVLPV-----------LVSARRISE

                                                                                                                                                            NTP-------------GWQKAADQAAA--EAKHPVLVVGAAI-VAIRALAER------LNIPVITTYGAV--TF--PV--DLVLTVG-DYA-DLR---PSWQKGIKKTVRISPNPIPYRPDVDVVT----------DVLAFVEHFETATAS----GA

                            KKDKLKVVAT----NSIIADITKNAGD-KIDLHSIV-YEP--LPE---K-EADLIFYNGIN--TAWFTKLVENAKKDYFAVS--------------DGVDVIY---HLNNGIIFAKNIAKQL-SANKE---NLKEDDK-DKESKDKFN---KI

                                                                                                                                         VAVFKLTA---VN-----DEG----------LGGTGARIGAEFLRRWYNATPVYVS-----SPTW--HN------FKDIRTYRY-LQGLLSDMEKAPEFSIFILHACATPDEWKQIAAVMKRRCLFPFFDSADAVRYF-LFCAQSF--RVL--------------KSIHEAVT

                                                                                                                              IYE-------------------------------SF----CGSV--AT-VF---FVSSAAAAPILCDA----EMVAHGV--T-RARLGNEVICTLSAAALKLWSERLA-GSVVAIGN--P--TALFFLLEMLAPKPAILGMPVAAEKDALFAIVRL-----------SAMTAAALNSLAR

                                                                                                                                                                                         MAVKKIAIFGGQTGLTTLAQAVQAG------YEVTVL-DV--KTVAGQ---DAVIVLLG-MSEGARNIVAAMKAHGVDKVVACTHIHKVLLKYVAVMPPHI--G-KHDLGHFMLRC

                                                                                                                                                                                           RVALTIAGSD---AGVQADLKVFFRFGVYGTSALT-VVYAQ-ESVA--LHAAKTGA-GDAAIVEAVAEAVRRFGVRLVVDPVM-KERLADLVTPNRLVH---HGTGCTLSAAIAA-EA

                               CKIVVVGDQCGKTA--LL-HVFTASELSLWDTSGSP---YDNVRSYPDSDAVLICFDI--LDSVLKWKGEIQTKMLLVG-GANMAKQIGAATYIE-----------CSA-SVRDIFHV

                                IGIFFGTGNAEAIAEKISKAIG----NAEVVDVAKAS----QF--GFTKVILVAP-TALQTDWEDFLGTLDFIGLVGLGFAEGIFHIY-VGLVIDED---QD-----DLTDERIAKWVEQVRG

                                                                                                                                                   VLKITEEML-FAS--VC--YD----------QRLYDQ-GHRNISYLGVPTTGKRRHEAYLAFCKAHKLHPVAALPG-NVAKVITPE--TTALLCATDT----ALGASKYL-RITLQLASVG-TPLMLHEIVTVDPGY

                                HGIAVAGTHGKTTTAMISMIYTQAKLYLIAEADEFLH----------QPMVSVVTNM--KATYVKFLHNLPFYGLAVMCAMELV-KVGRQVITYGFS----KH-ALNATAALAVAKEEGI----AN----------------GW------VMIF

                                                                                                                                                                                           KTVIITG----RGLGAEAARQAVAAG-ARVVLAD--HLD-RVVAY---VDGLVNNA-S-VEINLTGVFIGMKTVIIVNISSAAGWGVLSVNSVHPGM--TA---GEPGEIAGAVV

                                                                                                                                                 LI-NL------CQP---------LGGTGARIGAEFLARWYN-TPVYVSS----PTW---HN------FKDIRSYRY-LQGFLSDLENAPEFSIFVLHACATPEQWKQIASVMKRRFLFPFFDSYQ-IRYF-LFCAQSF

                                                                                                                                                                                          ARRILVVED--EAPIREMVCFVLEQNG-FQPVEAEDYDSAVNQLNWP---DLILLDWM--GGSGIQFIKHLKRRDIPVVMLTARVLETGADDYIT------------KPFSP-ELV

                                                                                                                                                                                           GIVWVVDD---DSSIRWVLERALAGAGLTCTTFENGNEVLAALKTP---DVLLSDIR--PG-GLALLKQIKQPMLPVIIMTAHSDDAA-FDYLPK----------PF--DIDEAVALVE

                                                                                                                                                                                           KNILAIQS---HVGNSAAEFPR--RLGANVWPLNT-HLTEI-IAKLH--DAVLSGYLGSAEQGEHILGIVRQVKAKYFCDPV-HVRHASDIIAPN--RQ--PVGVGDVTSGLLLV-KL-AT

                                                                                                                                                                                           LEVVTAGEPGAEVNVAVALARLG----VKVGFVGLA--FD-YLEGV---RFLHLSGITPRAFSLWAMEEAKRRGVRVSLDVNYLERAGVDLLFLSEE-VE---GAGDAFAAGYLA-GA--L----LEV

                                                                                                                                         DP-ILLAD--------GKIGKTP-----EFGPGGG-A---VAFLAKNTSVKRVWVS-----NPSWPNHKSVFN-SAGLEVREYAY-ALINSLNEA-QAGDVVLFHGCCTLEQWQTLAQLSVEKGWLPLFDFADAERAFALIVASSYKN

                                                                                                                                                                                      LRLD-KCAIITG----AGIGKEIAITFAT-AGASVVVSD--CDIEALADFAI-DILVNNAGGGAYELNVFSFFHLSQLVAILTITSMAAAAALVVNGIAPG------AILGPQDIANAAL

                               KVALVT----GGASGL-VVKLLLGEGAKVAFSHDVDWTLVMAAVRLGTLNVLVNNAG--NTESVFIGCQQGIGSIINMASVKAAVSALTVNSIHPDG-----------------------------------YT-PMMQASKLN--------------------------------------------------------------------------------------------------------------------YMPERIAQLVL

                                                                                                                                                                                           MNVLVIEDDKFRGLLEEYLSMKG-----IKVESAEREAYKLLSEKH--FNVVLLDLL---VNGLEILKWIKERSTEVIVITGIKTEAMGAYDFLT-------KPCM-LEEIEL------NELL

                                                                                                                                                                                         PPKVILLVEDSADSRLVQEVLKT---STIDHELIILRDAAA--FLSPR---NLILLD---LN-DGREVLAEIKQLRIPVVVLTTSHDAS-VNCYLTKS-----RNLKDLFKV-QGIESFLE

                                                                                                                                                                                           CRVLSIQSHV---GNRAATFPLQVL-GFEVDAVNSLLYDGL--VNQY--DYVLTGYTRDKSFLAMVVDIVQELKLVYVCDPVMLPVYKVDIITPN------FVGTGDLFAAMLLAW--IKCAK

                                                                                                                                                                                           GKIYLGSPRERAAKAKELLAKN--PS-IAHVFFP---NDLTGISNA---TCGVFLYDMLDDGSAF-IGFMRAMHKPVILVPFTKMNIGVTTIIDGN---------TEFEKLADY--NF

 CSSAAT-------------------------------------------------------------------------------------------------------------------------------------------ELTA----------RTTG--------LDSDQ-EKVK----PQRIAIVHQQYGEGLARAVQDGLKKGNANVVFFDGIT--TL---ARLKNIDFVYYGG--YHPEMGQILRQARALKTQFMGPEGANLS-AEGLLVTKP----------------------GLNQSDDPAKY----LTWDE

                               KRLMVMAGGTHVFPGLAVAHHLMAQGWQVRWLG-TDFIRAI----AYKPDVVLGMG----GYVSGPGGLAAWIPVVLHEQ--KWLAKIATKVMQAFPG-----------GNPV-----------TD-------LAL--------------------VRVLVVG----ARILNQTMPQVAAKLGVTIWHQS--FIDDMAYAWA---DVVVCR-------GALTVSEIAAAGLPALFVPFQYWNAPLAKIIEQ-------------LSVDAVAN-----AER

                               VNVGTIGHVDH--GKTTLTAT-EYSHYAHTDCGHADYV-KN---TAPLDGCILVVAADGPMPQTREHLLLAREHVVVYVVELVEIRELLTPIIVG-----------SALC----------------------------------------------------------------------------------------------------------------------------------------------------LGLKSVQKLLDVD-PVPTR

                                                                                                                                                                                           MVLTVTLNPA---KGINVSIAL-SKLGVPSVATG---FLRRYKMTLS-VDCVVISGS--EGICNELVRLARERGVFVFVEQTPLEIYFPNVVKPDLRG-LL------GAGDAYVAG--IKHG--LEA

                               KRVVLAFTRPEATK-APVYLALRGIPLKPLVLLTG-NLD-------EGADYVLVHG---DTLTTFAVAWAAFIPVGHVEAGRRLTDVLTDLDFAPT-------------GQT---------------------------------VTVFVY-LLD------------------------------------------------AS-----------------------------------------------------------EGVYRVKENP-------------DGKA

                                                                                                                                                                                           PVVVVTG----RGIGKAIALSLGKA-GCKVLVNY--GDV-AMMKT---IDVVVNN---VIDLNLTGVFLCTQAATIINIASVVGAGVFSVNVVCPGFIATA---GQPENVAGLVE

                                                                                                                                                                                           MKLYMSVDMTEANYCIAEAFNSG----CTEVLVNDSM-VE-GLDDT---FRGALFLGYHAGELGLNAYVAGYYDVPVLMVAGAAKEALIPNVTTAAVKC--PRGRLLTEKTAFA

                                                                                                                                                                                           SKILVFGDSDAIGSSYAFAYLAREAYGLDTEAVALGVIT---AEGAE--QVILTDH--NEQQS--V--DIAEV-EVYGVVDHHRVANFETYMRLEPVG----SSSIVYRM----FKEHS-------VA

HLCSGAT------------------------------------------------------------------------------------------------------------------------------------------ELTQ-----------RTAG--------LDSSQG----ETVKPQRIAIIHQQYGEGLARSVQDGLKAANANVVFFDG-IT---ALIARLK-IDFVYYGG--YYPEMGQMLRQARGLKTQFMGPEGGNASLAEGMLVTMP----------------------ALERT-ALVKD

                                                                                                                                                                                           MNILLFG----TGQGWELQRSLA-PV-GNLIALD--CGV--TVRKLR-DVIVNAAA-HAQLLNATSVEAIAKAAAWVVHYSTYVKLAGEHLIFRTSW-----VYAGAELLADCTAH

                                                                                                                                              LDDQDAIAVEAAC-ALF-----IIFS-----------HLVALGHQQIALLAGPSVSARLRLAGWHKYLTRNQIQPAEREGQQTMQM-LGIVP--TAMLVAN--Q--MALGAMRAI-GLDISVVGYDDTEDSYPPLTTIKQDF

                                                                                                                                                                                           YTVHIVDD--EEPVRKSLAFMLTMNGFAVKMHQSAEAFLAF-APDVR-NGVLVTLR-----MGVELLRNLGKINIPSIVITGDVPVEAAVDFIEKPFE-------------DTII

                                                                                                                                                                                           KIALVTG----SRGGRAIAETLAARG-AKVIGTA--MLN-SVLE----VDILVNNA--IIETNLSSVFRLSKAVMIITIGSV-KAGLFSVNVVAPGF--MTR---GAQEIANAVA

                               EKILIFGDTDTICSAIAYADLKNKLGFNAEPVRLGLVET--AN---EVNGVILVDH--NE-Q-QS--IKDIEVQVEVIDHHRI--ANFETPYRAEPVG--------CTATILNK------ENN-----------AAAKDAEE----DIEDVKKR

                                                                                                                                                    PVVERDA-----NIVY--GP---NQNAPLAAYLIRHYGERVVFIGSD---YIYPRESNHVMRQH--VLEEIYIP--DLQRAVERIY-DVVFSTVV--GT-GTAELYRAIARRRPPIASLTTSEAV-A-QVVVAWA--------------------GRAAQAAGNWRVED

                               AMDITVS----IPPQQYFLEK--GDLVRVSVLV-PK--PQQ------EAEAYVLIGLG--QPWLEKLKAANANMKLIDSA-------------QGITPLEM-DPHIWLSL-VKRQATIA-KAQYEAAA---ALE-LNQELGQILLQRK---NNLTMVF--------------------------GET------------------------------------------------------EAIAAGV

                                                                                                                                                                                       KIIVKHVTVIG---GGLMGAGIAQVAAATG-HTVVLVD--Q--TDAASVVHSTDLVVEAIVENLKVKNELFKRLDKFATIFASNTSQITSIA-RFAG-------------FFLV---FSKA-VPYPMGPLHQ----SLNK

                                                                                                                             LFN-------AH--GG--FS------------------ANIGN----GETESIFTVASGLKPRRAMIV-----TPGF-AEYG--LA---EIRRWSLTDAILE-ALTPDL--DCLFLCTPLERPLLQAIADRCKSLNINLILDEFITGFALHIWVLRSLANYLL-----SAAQNERLLAALRNVL

                                                                                                                                              TPVR--W--HQ--PFLYV---GF---DHAEG-RE-TE-FGKFFP-TYYSVLYFSYISDVGDTFIHQVNRDNNFELSAYYTDAAKA-SLAHPD-VDFIYACS-TD---ALGAVDALAGRDIMINGWGGGSAE-DLDITVMRMND

                                                                                                                                                                                           ATVLIVGPN-GKSTLFNKLV--VEWKTFKLVDTC--GVF---IREA---DLVLFVVDGITKEDESLADFLRKSTVDTILVAVKPELLGFGEPIP---------EH--NINLDTLE-TIIEKLES

  VKP--ERISMLLS----------------------------------------------------------------------------------------------------------------------------------------------------------------------------KTIHIGGTN----GKGSVANMVSNILVIAVLEVG-LGGLDATNVVFP-LCSTIVTVDR-IEQIAWEKSGII-KEVPLVTGERKREKVMEMYVI---KV------GPHQIENAGVAGLPLS----KA

                                                                                                           TL--------------ME-----------------IG--------------YNIP------LGGSGAKVGADFLKRYFPESGVWVS-----DPT----VA----AGFE-STYPW-NDLL-ATLKTLPARSIVLLHPCCTNDQWDAVIEILKARELIPFLDIADAIRAIAALVSNSF

                                                                                                                                                                               TMVQALNRALEE-DLTLICYGTVMPEVLQAAAELAKAG-VSAEVLD-LR-WDAVMNSVA-GRVVLVSDAPRASFVSEVAATIAEDLAPPIRVTGFD-------------QD-----LPTVTRILNA

                               TVVLIT----GCSS--HLAVRLASDPFKVYATLDVSVAAARERVTEGRVDVLVCNAGL-NVVGTVRMLQAFLGRVLVTGSGGFALEGLCLSLIECGP------------------------------------------FMEKVL-------------------------------------------------------------------------------------------------------------------QNPEEVAEVFL

                                                                                                                                                                                           KKILVVDD--EESIVTLLQYNLERSG-YDVITASDGEALKK-ETEK--PDLIVLDVML--LDGIEVCKQLRKLMFPILMLTAEEFDGLADDYMT-----------KP-FSPREVN

    DKNT----------LLAYEA-------------------------------------------------------------------------------------------------------------------------------------------------------------TRHLK-DIVVVPILRAGLVMADGILELLP-----NASVGHIGYAK--LPPLNDDKEVFLLDPML-GVSSIKAIEILKEGAKKITLVAIAVEAVEDVKIYVAAGLGDA

                                                    DPILG---------------------------------------------------------------------------------------NL-YR-DDN------GKPY--RA-IGTGSLRVGANFLQRFFKFSDVYLP-----KPS---T---L-------QAYRY-FTGAMEDISKIPEKSIILLHACARQEQWKELASVVKKRNLLAYFDMADAWRHFDVVLSQSY

                                                                                                                                              DLSD---LYK-----F--LRVVP----SD-LQ-----DI--RYNWTYVSAVHTEGGESGMDAFKELAAQEGLCIAHSDKI--LL--KLERLPKARVVVCFCEGMRGLLSAM-------EFSLIGSDGRDVIANGGITIKL

                               RPLVHNI---TNFVMNTTANALLALGASPVMAH---AEEEL------LADAVVINIG---RRSMVKATEIALGKPIVLDP--LEILSRGVDVLKGN--------RVTGTGCMVAAL----SA----TFG-----EEAKYP

                                                                                                         YNPFL------------LP-----------------LTD----------------NAMLKDK-HQG--ANIL-PVLLKYKQAPVFISNF-------HFDTAAHVE-LNGCKAINIVGDFDIKKLKENIADNIAIVSTVT-SMSNLKEVYEIAKQHGIFVVMDSFIFDYKYADALTMSADP

                                                                                                                                               MTIIETP---------------------------LNELPF--YSKICGVSIVR-GESMESGLRAVCR------VRIGKIL--YEKLPADIRERWVMLLDPMCAAGSVCKAIEVLLRLGVRIIFVNLAIERVYKVRMVTAAVGIGDF

                                                   ILY----RAE-------------EV---------------------------------------------------------------------------------------------------------------SDVTLVAWGTQVHVIREVASMAKEKLGVSCEVIDLRTIC-KSVIKTG---RLLISHGFA-EISSTVQEECFLNLEAPISRCG------------YDTPF-PFY-IPDKWKCYDA

                                                                                                                                                                                       TDKDHQKVILVGAVGSSYAFAM-GIAQ------EIGIVDIFAE---YSDAK-DADLVVITAPNLKILKSIVDPIVDSGFNLIFLVVDILATLSFRVVGSGT-ATFGIATALARISKAILND

               KNV----------YLENKTVVIADEIVWKAGHTIVNELKKGNIAAEEVVFSNEVERINI-KAEAAIVIGVG---GG-KTLDTAKAVADYIVIVPTAAST-APTSPLVLV-IANAPPR

                                                                                                                                                                                           KGVLVLA----ASIGRAVADVLSQ-EGAEVTICA--CDLFEKVKEV---DILVLNAG-LFLNMIKIVRNYLPAMGRIVAITSRMAGFL-VNCVAPGW---RV-----EEIASVVA

                                RRVVSGGRGL----FAIIEELAD-KLGAAVGASRQVGGK--------PELYVAVGI-SGAIQHLAGMKDSKVIVAINKDEEAPIFQIADYGLVG--------------DLFSVVPELTGKL

                               GARVVVIGAG---VGASYVFALMNQGIAIVLIDA---------------------------------------------------------------------------------------------------------NESKA-----------------------------------------------------DYDDCR-DADLVVIC--NIAIFRSIVESVMASGFQGLFLVVDIYATW--RVIGSGT-AATGIAMGLARVTRAILHN

                                                                                                                                                                                           MRVGVLGK---GKVGTTMVRAVAAADDLTLAELDAGDPLSLLTDGN---EVVIDFTHPD--VVMGNLEFLIDNGIHAVVGTTGFTRQV-VLIAPN--HHPHKA---RTSFVP

                                                                                                                                                                         SGMGATSTLWTLL----RDEVLLG-----NTL-FA-LHHG--EFGVKLRHVDMAD-LQALEAMTP-ATRVIYFESP---DIAGVAKIARKHGATVVVDNTTPRPLGADLVVHSAGGMIA

                                                                                                                                                                                           KKVLIVED--NELNMKLFHDLLEA-QGYETLQTREGSALSIARENK--PDLILMDIQ----SGLEVTKWLKLAHIPVVAVTA-ERIGGCEAYIS-----------KPIS--VVFL-----ER

                              RKKLVIVGDACGKTCLLI---VNVADELALWDTA--G----DRLRSYPDTDVILMCFSI--LENIPEWTPEVKVPIILVGPERDMANRIGAFGYME-----------CSKDGVREVFEM

                               HAVVFTGAG-------YAIAELER-MGIVKAVIT-------------------------------------------------------------------------------------------YYVK---FGE--PLPQRTLFEA------------------------------------------------IEEAKH---CDAFMVVGSSLVVAA-ELPYIAKKAGAKMIIVNAEPTMAIFDVKIIG----------KAGEVLPKIVEEVKRLRSE

                                                                                                                                                                                           WKIAVVDD--DKNILKKVSEKLQ-QL-GRVKTFLTGEDFLND-EEAF--HVVVLDV-----SGYEICR-IKETRTWVILLTLLSSVAGADDYVTKP---------FNPEIL-LA------LE

                                                                                                                                                                                        FAEKVAIITG----SNGGRATAVLFAREG-AKVTITG--DVQ-EILSTK--LDILVNNAG--LNLNLRSVIALTKKAVIVNISSIASAAIYTVNSISPGL-----VAGQPQDIAEVIA

                                                                                                                                  LL-----DALFG------VD------GKPW--------LSGTGAHISAKFFSKFFPDKLVYLS-----PTW--NHMAI---NQGKTATYPY-LNGFLNAIQKAPEGSIFVLHSCATSEQWVQIVDAIASKNHIALFDTYQ-VRLGVVFVCQSFKN

                              HVNVGTIGHVDH--GKTTLTAT-EYDHYAHVDCP-HAY--VKN--AAQMDGAILVVAADGPMPQTREHILLGRPYIIVFL-VEMEVRELLTPIVRG-----------SALK--EAKILELAG

                                                                                                                                                                                          SMKVVLVGGAVGSSYAFAM-----QQGIEEFVIV--DV---GEYSDCK-DADLVVIT--NLNILSSIVKPVVDSGFDGIFLVVDTYATWSFRVIGSGTDKAFGIGTALMRISKAILRD

                                                                                                                                     PYQSA----------------------WL-NEY-----RGADEGIELLIR-AFCEDAILYC----PPT--GYS-VSAETIGVECRTVPDLQGISDKLDGV---KVVYVCSPLINPQDFRTLLELTRGKAIVVADEYISLAWYLAILR-T-TNYIL-----TREESQRVIDALRAEQV

                                                                                                                                                                                           GSLVVLGSINKGANQAVAAGRSG----ANIAFIA--L-AQERIANA---SALLMQLESPLESVMAAAKIAHQNKTIVALNPARELPLLVDIITPNET--DTIA---DTFNGALITAEA-------IDA

                                                                                                                                                                     QHK------FEI---DLP---KKLGVIPILRAGIGMVDGILKLIP-----AAKVGHIG--VK-LPSDVEERDFIIVDPML--GSAVAAIDALKKGAKSIKFMCAGVKAVHDVDIYIAAGLGDA

                                          GDYNLV----------------------------------------------AL-AFD------------LEMAKNITAA--AIY----------ACN--------ALF----------NDE-AS-ESLNAAVDETLKFIA--NRDKVAVLVGLRAEEAAVKFTDALG------GAVATMATSWSYVEKTMKEADAVIALA---VFNST----IPDPK--KLVLAEP---------VVPSV-------KDYLTRLAQKVS----KK

                              KKTIYFGAGWRQNKAYKEAMEALKENPTI-YVP-----------------------------------------------------------------RVD-------------------------------HDKV------WATATYNN--------------------------------------------DL-NGIKTN---DIMLGVYIEEDVGLGMELGYALSQGKYVLLVIKPINLMVSDNVI-------------KMSQLKDFNNK

                                                                                                                                            FS-DDWA--RPL-----ILP------WSPKD-----VADP--ITFRMKTRFIIHGFIDKGWLSNICKNLFKVESVNCICVDVGEVA-YFVEYSPSNVHVIGHSL-----HGEAGRRT-GTIERITGLDPAE-RLDPVDVIHTD-----VA-LRSYKYYADSILN

FK-AELN----PE-RALY-RI---VE-ANKGTLALVGIHTRGIPLAHRIARFIAEEGKEVPVGVLTRI-------PFD-KAIVLVDDVLGRT-AALDALIDRPRRIYLAVVD-----IRA--DFVGKNV-EVVKVRV

                               PLVVTTI-----GMIADAVKIAQGDVHLKGLMVDP-YT--AT--GDEWLGLILYNG--LHL--ETKMGEV-SLRVVAVSE-------------TIP-QRL--FDVKLWSYSVKAVYESLCKLLPGKTR------------------------------------------------------------------------------------------------------------------------------QRYQAYQQQLDKLDAY

                               YLVALTGAG-------QAFAELER-LGVLKCLIT----LDR------RADVIIVAGTSAVVQPAASLPLIVKGAIIEINPDETPLTPIADYSLRG--------------KAGEVMDELVRHVRK

                                                                                                                                                                                           MKILVIQGPNLNTL-DQIHEIMQTFVDVELEFFQTGEIID-KIQESV--EGIIINPGASHTS-IAIADAIMLAGKPVIEVHNIKNSYACGGVIMG----------FGPLGYNMALMAKAFQEA

                                                                                                                                                              STPAAL---DA-RKEV-AHYKDV----PITKVVGIESR-GFILGGIVANSLG----VGFVA--LRK-IEVQKRQLGPHDVLLHDDVLATGTLLAAIELCETAGVIYINVLYE-GRVKCTRLFSVIRE

                                KILVIGPSW---DSQSLYRTLQARPQAIIDVA-------------KRYDRAYVLP--NSFK-SALVPLFAGIPHRTGW--RGERYGLLNDVRVLDK--------L--VERYIALAYD---------PQ-------EGEKS---YTCNSL--SSER-PIGFCPG----YHYAELAKQLID-EGYQVVLF------------AA----AIVTND----GLHVAAA-LN----RPLVALYSPDPPLSKARVIRLI--HQSLIDITPQRVLE

                               STAIVT----NVKHGM-SALRLSEAGHTVACHDE-QEPAELEAVAYGQVDVLVSNDI--LQIRPFALVNAVAGHIIFITSA-AGACTLAVFAIGPNY------YFY-----QKELGEL

                                                                                                                                                                                           KAVAINGY---GTVGKRVADAIAQQDDKVIGVSK--VAIPTVDDMLD-DIVIDCTP--EG-IGAKNLKMYKEKGIKAIFQGGEKHEDI-YTRVVSCNRRGAD

                         QQ-LENIKFVITDVD-L--------IKLD--ADIQVAVLSGF-LE-----QAGVTQTAYIGD----DSVDLPAFA-ACGTSFAVADAPIYVKNAVDHVLSTH----------GGKGAFRESD--ILQAQGKS-FD

                               KTALITGSRG---IGRAFAEAYVREGARVAIALDVSIDRCVAELRWGS------------------------------------------------------------------------------------------------------------------------------------------------------------IDILVNNAAL-FAINVSGTLFMMQAVAIINMASQAGAAVLTVNAIAPGVV-HW---GRAEDLTGMAI

                               IEVAFAGRSAGKSS-LN----FEVADKRLVDLPGY--QRAL-----RQLQGLVVLMDIPLKDLDQQMIEWASNIAVLVLLLNMV-VLAGDVQVET-----------SSKQGVDKLRQKLD

                               IKCVVVGDGAV--GKTLL-IT-YSALGLWDTAG-QE---YDRLRSYPQTDVFLICFSL-SYENVRAKFPEVRTPIILVGYGLALAKEIDSVKYLE-----------SAQRGLKTVFDE-LCP

                                                                                                                                                                         GEGVLKEVPP-------AGPAALLFDRRVEGAQ---AK----AL---RHLLGL-KVL-SWLAGLPRNATLLVVGGGT---TDLGGFVAATYGVAYLAFPTIVDA-FPQGVYAELLKTL

                               KRALVILAKGA-EETVIPVDV-RRAGIKVTVAGLAGSLEDA-----EGYDVVVLPGGNAQNES--AAVKEIEQEIAAICA--TALLAHIG---TTHPL--------GPGT-SFEFALAIVEAGKAAKAVLK

                                                                                                                                                                   TAD--FEY-K------GAVE-AKAAGARILVARMIACG-LN--ERLRL---FGNEVVELLYAWEK-L------GAIVGVGNAPT-FLLAL-A---GARPALVLGMPVLEAAP-VPWIVTKG-----GSTLVVAALHALIRLAADG

                                                                                                                                                                        RGTTEGNLVANSWGNSNVRDNIIISQMHH----NIV-WQM-CAR-GAELRVIP-LQLET-LPTLFDEKTRLLAITHV---PLAEMITLAHQHGAKVLVDGA-VDVLDCDFYVFS-GHK----------------LSQLESVPLTLYFNL

                                                                                                                                                                                           KIIYFLCNSCRSQMAEGWAKQYLG--DEWKVYSAGIIIDSDILNNA---DLVVTLCGD----ADKC--PMTPPHVKREHWGF---------------AQ-FRVRDEIGNRLKEFAETG

                               VDLVFLFDGKILDFMKDVMKKLSNTSYQFAAVQF---SYKT--DFLGA-KVLIIITD--GEA------IAAKDIIRYIIG-QETLHKFASFVKI--LDT-----FEKLKDLFTELQKKIY

                                                                                     VSD-N-----------------A-----------PSP-----------------------KL-----------PTL----AR------LCMA----TA--ICDYALVP-----PGF--PHYETVCKAYGIGMHFYNCEADLDEIRRLK--TKLLIVTNPNFRKHVEDIVRLAEELRLPLFSDEYATSADF-RVILGGT----AK----PVEVYREAVERIKAFCQ

                                                                                                                                                                                SAEDAA---NASKVIIVPGYGMA-QAQHALREMADVLKKEVSYA-IHPELEEINSSFTADVAFVIGA---NDVTNP---DVEK-AGTVLFIKRSM--ELFTMMLFG----------DAKKMTEQIVQ

                                                                                                                                                               FDNNATTTS-CATESNWILKTVAETFEKRTIITT------PIE--L---M-KYLSKVKYVPV--VKLEELEKLVDEDTLVSIMAAIQ--PVEDVTRIVKKKNTLVHVDAVFSLELEVDYASFSA--HK----GI

                                                                                                                                                                                           KKISIIG----GFVGSTTAHWLAAKELGDIVLLD-IVT--NNYADTANSDVIVVTSGVNADITRACISQAAPLSAVIIMVNNPDAYLAAVIGQA-G--GGAAPAAATAQMVEAVLKD

                                                                                                                                                                        SGMCASTVMLLALV----PGHIVTT-----TDCYRKTRET--PKMGITATVIDPADVGA-LELAL--KVNLFFTESP---DIELVSKLCHEKGALVCIDGTTPKALGADLVLHSAGGAVS

                                                                                                                                                                                           KTIAVVN----GRQAASLIRVAAAV-GHHVRAQV-L--PLTLFEGA---HLAFINTTSEIAIGKDLADAAKRAGTIYIYSSMKFTNYVRPSTFVY-AGIYNWL-----DVGPALL

                                                                                                                                                               LDYSATT--SGATES--LAKGAANFYQKHIITS------KTEH--L--TCR-QLEEVTYLAP-IIDLKELEAAMRDDTLVSIMHVVQ--DIAAIGEMCRARGIIYHVDASVIDLLKVDLMSFSGKI------GA----------RIE

                                                                                                                                                                                             MKVAVGQALALLLKT--QLPSG-----SELSLYDFDATPALEGA----DVVLIS--AGGIVKNLVQQVAKTPKACIGII-VNTTAA-LFGVTTL-DATLSMGQAAARFGLSLVRALQGE

                                                                                                                                                     PWAGRPIKSLPSD----PK--TATDIATIK----FNLNKTRFIIHGTD-GEWLSDMCKNMFQVEKVNCICVD-VEVA-YLVQLSPENVHIIGHS------HGEAGKRL-GLVGRITGLDPAE--LDPVDVIHTD-IS-----HRSIEYYHSSIL

                               EEFAVTGTD-GKTTTTAVAHVLKHLRK--VYELDEFF-----------PNYLIITN---ARG---A-FEKINTDLVVTF-EDELTSHLGDVTFGVK---------GFHNVLNALVI-D---GYDLA---------------------------------------FR-GVHRRFS--DYAPFQP

                                                                                                                                                                                           KVALVSG----RGMGASHVRAMVAEGAKVVFGDI--HLD---KAAV--LHVLVNN----LDVNLTGVFLGIRAVVIINISSIEGFAVLTVNSIHPGL-MTD---AEPVEVSNLVV

                                                                                                                                              TES----------------------PETLKAIDFL-AM---SPAP-THILGFDARGFLFGPMIAVELE------IPFVLMRK-TIR-YGSIGKGSRVVLIDDVLGGTALSGLQLVEASDAVVEMVSLS-AA---IKFISLLSD

                               VNIGMVGHVDH--GKTSLTKALTGCEVSFVDS---GH-ETL-----SLMDGAILVIAACPQPQTKEHLMALEDKIIIVQ-NYEQIKEFV-----------------------------------------------------------------------------------------------------------------------------------------------------------AENAPIIP---------INIDVLLKAIQDIP-TP

                                                                                                                                                                                           VNVAVNGY---GTIGKRVADAIIKQPDKLVGVAK--YVPQTVEDLIKSDIVVDTTP--NG-VGAQYKPIYLQLQRNAIFQGGEKAEVA-YIRVVSCNRRAAD

                                                                                                                                   RNK----------------------------------TDIQKVIPLFLND---E---EAIILTPTELAIQVADE-IE---LKNLNIVVGTPGRILDHI-LNLK-VKYFILDEDELN-GFIKDVEKILNACNRILLFSATILNLA

                                                                                                                                                                                           MKITVLGC---GALGQLWLTALCKQ-GHEVQGWL-RV---NDPDFLA-SDLLLVTLKAWQ--VSDAVKSLASTLPPILLIHNGMGEEL-PLLMGT-THAAR-------IT---ILQTV

                                                                                                                                                                                           KVWLITGVGF---IGSNLLETLLK-LDQKVVGLDDI--D-NACAGV---DYVLHQAALNIDGFLNMLIAARDAKVSFTYAASKYVNYASTIGLRYF-N-YAA---Y-IENTVQA

                                                                                                                                                                                            MRVLVTGGYIGSHTCVQLLQNG----HDVIILD-I--L-EILHDHA--IDTVIHF--NVNGTLRLISAMRAANVKNFIFSSKLEQIL-SIALLRYFN-PV---V-LADGHVVA-EK

                                                                                                                                                                                        PD-LDVILLLDG-YFDE-KSFAKAFISKANIQVSVLQYTT-F---RYLT--SKAVVILVTDVSVDVDAAADAARSNRVTVFPIGIYDAAQILANVVKLQR------IEDLPTV-----LGN

                                MKITVIGAGGATTAFRLAEKQ----ARELVLLDVNDY-----ADTA--NSDIVVITNAIVREVTGRIMEHSKNPIIVVLDTHVAWQKSPRVIGMAG-RT--GSASPATSVVEMVESIVLD----RKRVLT

                               RVVLIT----GGGSGR-TAV-LAAEGAKLSLVDVAQVEA-VTATRFGRIDGFFNNAG--NLRGVFLGLEKVLGMVVNTASGGHGVVGLTINAIAPGA------MVE---------------------------------NSMKQ--------------------------------------------------------------------------------------------------------------------GEAPEIAAVVA

                                MKITVIGAGGATTAFRLAEKQ----ARELVLLDVNDY-----ADTAN--SDIVIITNAIVKEVTDNIMKHSKNPIIIVLDTHVAWVRS-RVIGMAGLD---GSAAPASSVVEMVESIVLD----RKRVLP

                                                                                                                                                                                            CPAAVITGRIGHSIAVRLHQQG------FRVVVH-CII-CSFRGR---CDVLVNN--NAVAPLFLIRAFARRQ-LSVVNLCLGGLTAAIRVNAVAPGL-SL-AAQIADAIAF

                                                                                                                                                                            SGMGAIAATVLTIL-DHLISD-ECLY---HAL----FEHALTQVDFINTAIPGE---KHMKPNTKIVYFETP----DMERVCKDAHSQEVLVIADNCTNPDFGVDVVVHSAGSMIT

                                                                                                                                                                                           PHFLILNGPNVNR----IETDLFQFAEQLTFFQS-GDLID-AIEAE--SGIVLNPGA-SHYS-YAIRDAVSSISLPVVEVHRHQSVIVAKGQIVG----------LGAEGYKLAV

                               KQFAVIGLGRF---GGSIVKELHRMGHEVLAVDAT--ENELLSLGIRNFEYVIVAIGA--IQASTLTTLLLKPNIWVKAQNYYH-HKGADRIIHPE

                               AKVAVLG----GGIGQPLSLLLKNSPLVLTLYD----PEQL----LKGCDVVVIPAG--NATIVATLTAACAAMICIISNPVNSTIPIT-------------------------------KKHGVYNPN--------------------------------------------------------------------------------------------------------------------IFGVTTL--ATLSMAYAGARFVFSLVDAMNGK

                                                                                                                                                                                           MRVLLSVCRGDVEIGVALADRLKA-LGVQTRMCA--VAV-GAAEGC---AAVVAVG--DLAAATGVRSVAEKLGLPFFYSVPYLFGYGGERPLLAA---------AWLESLSAA

                                                                                                                                                                                                     AHLALAKLQDA-L------RFLLVTHMEIYMALSMA---DIFIAIGTSGHVYAAGFVHEAKLHGAHTVELNLEPS-QEFAEKYYGP------ASQVVPEFVEKLLKGLK

                                                                                                                                                                                            MKIGILGRVGSSTAFALLMKGF-----AREMVLIDAGD--DLKGS---DVVIVAAG--NRVMKEIARNVSKYDSIVIVVTNPVLYFFLVFGSGT--AYGATHYAIALAVADIVES-FF

                                                                                                                                                                                           DTIALVVSTL-FVSLKDGAQKEADKLGYNLVVLDSANVQ-DLTVRGT--KILLINPTRSDA-VGNAVKMANQANIPVITLDRQ-TKGEVVSHIAS------IKPDQIGAKG-ET

                                                                                                                                                                                           MRVLLATCRGDTEPLVALAVRVRDLG-ADVRMCA--V-I-AAAEGC---AAVVTTG--LLAAAIGVRSVAEKLGIPYFYAFHYVFTFG--HPWVA----------AWI-SLSAA----LTPHAR

                              LAVALTTG----AGIGRGIAIELGRRGASVVVNY--EVVALFDKAHFGGLDFVMSNSGM-NTRGQFFVAQQGLGRIILTSSI-AAVEGFCVNCIAPGG------MF-------------------------PL--KRI---------------------------------------------------------------------------------------------------------------------------GYPADIGRAVSA

RCIRT--DMSLK--------------------------------------------------------------------------------------------------------------------------------------------------------PNDAESEKEVIDTILVLIKDAKNPVILAD-----RHDVKAETKKLIDLTQFPAFVT---MG----VYAVESAILSVGAL---------LSDYSYK--TKIVEFH---------IRATFPG--------QMKFVLQKLLT-IADAAK

                                                                                                                                                                             DPSTI------FQTKTRFIIHGFI--NWLLDMCKNMFKVEEVNCICVD-V--AQQMLSLSPSQVQLIGHS--AH---GEAGSRT-PGLGRITGLDPVE--LDPVDVIHTD--FVAC--LRSYKYYSESILN

                                                                                                           VNA------------KAL-----------------TA----------------PDF--------VGGSQALFNLF--AILDEVIVL-----SPYW--YPE-VR-FAGGVVVEVEPDRVR-RAITPT---KALVVNSPYPKEVLEALARLAVEHDFYLVSDEYEHFSPG-TLTVNGAKAFYV-----SEENLRKALERFARVL

                                                                                      VKDE-------------------YA-------------LTTR----------------------------------------TGPTALH------RRL-GWHQALVLYADPCFFIVEGLYMRVRERLNITVNHQEF--LL--AVRKG---RVIYICSSPDA-NLMLLAL--LT-DYVFFHLDQSLPWFQAAKIITYGLK----------------LYVQAVTET-NITQR

                                                                  SL--DRVAAA-----------CE--------------------------------------------------------YAA------------LSAGRVAP--------MMLALFRHHWSRAALVYSDDRNCYF--EGHEVF-QEEGHTSIYSF----LEDIVRNIQ-ERVVIMCA--SSDTIRSIMLVA-GMDYAFFNIESS-DGSYLQTVTL--NMF-------------------VLRAGYSKKD

                               VNVGTIGHVDHKTTLTA---T-EYEHYSHVDC---PGHADY----AAQMDGAILVVSDGPMPQTREHILLARPYIVVFM-VEMEVRDLLVPVIRG-----------SALL-----------------RRGEN---------------------------------------------------------------------------------------------------------------------------EW-----KIWELLDA------TP

               RILTLLH------------YIHVT-GKGSAANAIAHVLEASGL-VAVIEVDSTN------------VVSVLTEV----HKAGII--KRGIPVVTGNLAAVVAAKVQWLRFD-VP------GDYQQRNMA-IQKV-AKQTEWPL-TPQNIRQGLAAS------KIS----PLI

                                                                                                                                NRK--EAT-AA----------------------------IE----GFIG-DPVVRRFG-GEAIILGR--A--L--AIVKELMG-MGFMLFICD-FTQIVHAANYAQRIRAFVLYLGEHDMVKTAAAFGAIFTGFPVITDQPLPKQ--WFFSVE---------------DYDKIV-----LTKIK-DL------PIYV

DFP-PVLKDPASF---IGLL----------------------------------------------------------------------------------------------------------------------------------------------------------R-HLKATHG--RIDYIAGLDSR-GFLFGPSLAQELG----LGCVL--IRK-LEIQKDALPGQRVVVVDDLLATGTMNAACELLGRLQAEVCVSLVE-REKLPVPFFSLLQ

                                                                                                                                                                                           QRVFIAG-GMVGSAIRRQLEQRG---DVELVLRT--L-V--FFSER---IDQVYLAAKNMMIESNIIHAAHQNDVNKLLFLGSIIKLC-DYRSVMPTN---LYVDMAAASI

   PCL----SARVNMGTKL-------------------------------------------------------------------------------------------------------------------------------------------------------EKIRE-WEDLD----I-DVVIPIPETSCDIALEIARILG------PYRQ----GFV-NRAEFRDKNVLLVDDSIVRTTSEQIIEMAREGAKKVYLASPEEIIIGADGLIFQDL---LI

                                                                                                                                                                                           AKIVLVGS---GMIGGVMATLIVQKNLGDVVMFD-IV---NTYDDLKDADVVIVTAGLNNKIMIEIGGHIKNNCAFIIVVTNPDVQLLHKIVGLG--DTAPAPAAAIIEMAESYIRD

                                                                                                                                                                                           KVVVIDAKTFNLAMALKVESILKQNPKLEVVLTR--FLE---VKVAE-ANVFVSIHAN-----FHVIRET---TMPAVLLEVG--------------KEEATL-FRVAQGIADGITE---YLDVK

                                                                                                                                                                                      QRR--KKVAMIGS---GMIGGTMGYLCALRELADVVLYDV-YSY-AALTGA---DCVIVTAGLNSKIIREIGQNIKKYCTFIIVVTNPCMKVMCICGMA----GSAAPAASAVAMATSFLNDNKAVAA

                                                                                                                                   IEAI-----KTLRF----------------KP--------TEIQERIIPGALRGIKQAVITAPTRELATQIYHETLK---TK--HIVIGTPGRINDFI--DVH-AHILVVDEADLLDGFITDVDQIAARPLQ-LVFSATIP-LK

QKA----VILD-AI--A-RI-HEM-E--RNK-CILVGIKTRGIYLAKRLAERIEQIGNPVTVGEID--VGAD--IPVDIQKVILVDDVLGRT--VRAGMDALPSSIQLAVRG-R---IRA--DYIGKNI-KV-MV-----------------------------------------------------------------DEVDQ

                              LGQALCIASAEDIQHENVIANLLTQYGYTKIIKCVT----KN------GGIS-VNYTGHGSWGHFG----QLTNLPFIFDVVNGCFAEALVAIIA---QY----WAPPMRGQDEMNEILCE

                                                                                                                                                                                           LKVLVMDE--NGVSRMVTKGLLVH-LGCEVTTVSSNEEC-RVVSEH--KVVFMDVCMPVE--NYQIALRIHEFRPLLVALSGNS-KFGLDGVLL------------KP-VSLDNI

PER----GKP------GKLF--SV----EREIDVVMTVATKGIPLAYAAASYLN-----VPVVIVR--SLAKRS--MKGSNVLIIDDFMKA-GTINGMINLLNVAGIGVLVEGV---LVDEYMSLLT-LSTI

                                                                                                                                     MGIFEM------KP--------------------SPIQEESIPIALSG----KDNQAMVIVPTELALQVSICIQS--HMGGAHVVIATPGRILDLI-AKVD-HVQMIVLDEKLLSFV-QIMEDIILTLPQILLYSATFQKFSHL

                                                                                                                                                                NVLAEMVNNSGTEA-AVLRLMRAYTGRDKIIKFE--GC-KA--------KKT-TANTLTTPYNDLEAALFAE---IAGVILEPIV-AGFLEGLREITLEHDALLVFDEMTGVQVTPDLTTLGKGMFGEEDIDATLAAARTVMSAL

TAK-------IAL--GVPIL-EYFEG-KNLEDIVIVSPDHGGVTRARKLADRL----KAPIAI---IDK------------------------------------------------------------------------------------------------------------------------------------------------------------MNIV--NIEGKTAILIDDIIDTGTITLAANALVENKEVYACCTHP---INIKELVVTNSI--------VGPLLAE

                                                                                                                                                                                           TVPVALVTGRLGRSIAEGLHAEG------YAVCLH-VLV-ACYTGR---CDVLVNN--NAIAPYFLIKAFAHRV-YSIINMVLEGL-AAIRVNGVGPGL-SV-AAEVSDVVIF

                                                                                                                                                                                           EKVLVTG----GAIGSHTVLELLEAG-YLPVVID--MDALRLFKKYS--FMAVIHF--NLTGTIQLLEIMKAHGVKNLVFSSKFEEMI-NAVLLRYFN-PT---V-LAKGHIA

                                                                                                                                                                                           KVALVTG----QGIGKAIALRLVK-DGFAVAIAD--YVD--AVEQ---FDVIVNN----YNINVKGVIWGIQAAVIINACSQAGFAVLTVNGYCPGI-----VKLSPEDVAACVS

                                                                                                                                                                KI-PW--PENT-----VADP--IQFNTKTRFIIHG-I--SWLSTMCQNMFKVESVNCICVD-VEVA-YLVGLQPSNVHIIGHSLSH----GEAGRRT-GAVGRITGLDPAE--LDPVDVIHTD-AA-----LRSYKYYTDSIL