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LATVFPFAGRVLDETPLLGEGPTFDPASGTAWWFNILERELHELHLASGRKTVHALPFGSALAKISDSKQLIASDDGLFLRDTATGVLTLHAELESDLPGNRSNDGRHPSGALWIGTGRKAETGAGSIYHVAKGKVTKLFADISIPNSICFSPDGTTGYFVDTKVNRLRVPLDARTGLPTGKAEVFIDSTGIKGGDGSVCDAEGHIWNARWGEGAVDRYDTDGNHIARYEVPGKQTTCPAFIGPDASRLLVTSAREHLDDDAITANPQHGLTFELGIEVKGRFEPLYRL

 IPVIEPLFTKVTEDIPGAEGPVFD-KNGDFYIVAPEVGEILRIDLK-GKKTVICKPEPAGCQCDAN-QLFVADRLGLLVVQTD-GTFEEIAKMQ------GCNDCAFDEGNLWITATR-MQEKFGSIYCFTDGQMIQVDTAFQFPNGIAVRHMPYQLIVAETPTKKLSYDIK--GPAKIENKKVWGHI--GTHADGMDFDEDNNLLVANWGSSHIEVFGPDGQPKMRIRCPFEKPSNLHFK-PQTKTIFVTEHE-------------NNAVWKFEWQRNGKKQYC

       QTVLPFTLS--PSGVAVDSA-GNVYVTSEGMYGRVVKLA----TTVL-NGL-GLAVGT----VYVTDNNRVVTL-GSN-NQTVLPFDGL----NYPEGLADTQGAVYVADG------NNRVVKLAASKTQTVL--LNDPDGVAVDN-SGNVYVTDTDNNRVKLEA-------SNNQVVLPFTD-ITAPWGIAVDEAGTVYVTEHNTNQVVKLLAGSTTSTVLFTGLNTPLAVAVD--SDRTVYVADR--------------GNDRVVKLTS

      KTEAAFLHI-KVIIGLAFDCVDKVVYWTDI-SPSIGRASLGGEPTT-RQDLGPEGIALDGR-TIFWTDSDRIEVAKMD-TQRRVLFDTG-----VNPRGIVTDRGNLYWTDN----RDNPKIETSHGTNRRILAQDLGLPNGLTFDAFSSQLCWVDAGTHRAECLN-----PAQPGRRKVLEG--LQYPFAVTSY-GKNLYYTDWKTNSVIAMDLASKEMDTFHPKQTRLYGITIALS

   DRS-YTS-IPN--RNVVALDTEVASNRIYWSDL--RMICSTQLDR-YDT-ISRDIPDGLAVDHS-NIYWTDLGTVSVADTKGVKRKT-LFRE---QGSKPRAIVV-DPFMYWTD------TPAKIKKGGLNDIYSLVTEIQWPNGITLD-LSGRLYWVDSKLHSISSID-----VNGGNRKTILED-EK-AHPFSLAVFEDKVFWTDIINEAIFSANRGSDVNLLAENLL-SPEDMVL-------------------------------------FHQLTQ---PA

   RQRMIYHCKFGE-TEPSGVAVNAQ--DIIVAD--TNNIQIFDKE-RF---GELLYPNRVA--NSG-IIVTERHQIQIY-GQ-----KFGAIL-----QHPRGVTDNKGRIIVVEC-----KVMRVIIFDNGNVHKFGCSLEFPNGVVVN-DKQEIFISDNRAHCVVFN------YE--QYLRQI-GGEGNYPIGVGINSNGEILIADNHNFNLTIFTQDGQLISALESVKHQCFDVALM---DDGSVVLASKD--------------RLYIYRYV

      QIN-VYT-GKNYIRSCKLLPDGCTLIVGG-EASTLSIWDLAAPRI-ELTSSACYALAISDSKVCFSCCSDNIAVWDLHNQTLVRQFQGH-----DGASCIDISGTKLWTGGL------DNTVRSWDEGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHV------NKPDKYQLHLHE----VLSLKFAYCKWFVSTGKDN---LNAWRASIFQS------SSVLSCDI----VDYIVTGS--------------DK-----TVY

                SKIAAISW-AA-RQQRVYFQD-IREAQRGG-NPWTGGVIGEALAAVTWKQGIQIRVYCVLSEFVYDSK--WITGQLG--VKV-GS--LAALQWGPNIRVYYQ-SNGSGSIHEYVWSGKWTAGASFG-TGIGATAIG--PGRLRIYYQAIREHCWDS--------NSWYVGGFSAS-AS-IAAISWGSTPNIRVYWQELYEAAYGG-SWN--QI-----F-IAANSS---GNIDISVFFQ-------------ALQQWQWIS

                                                VNAAETEPVD-DPAIWLDQNSKLITTNSGLAVYSLE-GKMLH-YHTG------KLNNVDIRYDIAAASN---RS--GNTIEIYAILQS-PIA--DEVYGFSLYHSGKYYAMVTGKEGEFEQYELN----ISGK-KVRAFKM--NSQTEGMAADEYGSLYIAEEDE-AIWKFSGGSNGTVIDRHLTPDIEGLTIY-AA-GYLLASSQ--------------GNSSYAIYERQ-----LGFGL

KLIKRTE-------------------------------------------------EPISWTFDER--KNIYGAAKSSFAVKSPT-EIVHEASHP--NANTRAIFLLAKQYAVYANP----YKFAGYGNVFSVEKNVQNYEENTGIHG-VFDPTETYLYSADLTANKLTHRKL-ASGEV--ELVGSVDA-PGDHPRWVAHPTGNYLYAL-EAGNRICEYVIDVYTHHSFPLI-YRADVCALTF-SGKY-FASSRA--NK---E---LQG---IAGFKL

                                          ISVID-TATIPVGSNSPQGVAVGK---VYVTNSTLSVI------NTVAGTVKT-----KSPLGLASPDGKLYVTN-NG----DKTVSVINTKAVINTVS-GRSPKGIAVTPDGTKVYVANFDSSISVIDT------VTNSVIDTVKV--EAAPSGIAVNPEGTKAYVTNVDNTVSIDTGTNKITARIPVG-PDPAGIAVT---PDKVYVALSF--------------NTVSVIDT

                  ITALSSSADGKTLFSAD-AEGHINSWDISTGI-----HATITGIKTTKG-DLFTVSWDHLKVVPGVDSSKAVANKLS-----SQPLGLA--GDIAVAAC-------YKHIAIYSHGKLTEVPISYNSSC-VALSNDKQFVAVGGQDSKVHVYKLS---G--SVSEVKTIVHPA---ITSVAFSNGAFLVATDQSR-KVIPYSVFEL-H--WTFHTAKVACVSWS---PDRLATGSL-----------DAMSSV-------LN

   QMRTTLRG-HLSQ--VMTCAYAPSGNYVACGG-LDNIC--------------AGHLSCCRFLDDNQIVTSSGDTCALWDIE--GQQ-TFTGH-----GDVMSLSLATRLFVSGAC------DASAKLWDEGMCRTFT--ESDINAICFFPNGNAFATGSDDATCRLFDLR------ADQELMTYSHDNIICGTSVSFSKSGLLLAGYDDF-NCNVWDAKADRAGVLAR----VSCLGVT----MAVATGS--------------D----FLKIWN

       DVELKSLD-VVRS-VCFSPDGKFLATGA-EDRLI------------R-QGHIYSLDYFSGDKLVSGSRTVRIWDL----GQCSLTLSI-----DGVTTVASP-KYIAAGSL------DRAVRVWDSGFLVERLD--DSVYSVVFTRDGQSVVSGSLDRSVKLWNL---------TCEVTYIGH-KDFVLSVATTQNDEYILSGSKDRGVLFWDKSGNPLLMLGHR-NSVISVAVANGS--VFATGS--------------C----KAIWK

                            TRIAYV-----ELRVSDY--YNQFVVHPQPLSPAWS-----SKLAYSALVI-QTLANGAVRQ--VAS--FPRHNGAPAFSPDGSKLAFA------GSLNLYVMDLGQIRQVTDGSN-NTEPTWFPDSQNLAFTS-RPQVYKVN------INGGAPQRITWE-SQ--QDADVSSDGKFMVMVS-QQHIAKQDLATGGVQVLSST-FLDETPSLA----PNTMVIYS----SQG--------GSVLNLVST---SP

                     ALTVNPL-----------SY-------------DGSNLIVSLDN--QEYSSISWDDTLKN------GITKHEFG-----QPKVASANNDGFTAVLTN------DDDLLILQTGDIIKSVRLSPGSAVSLS---QNYVAVGLEEGNTIVFKL------SD-EVSFDLKTP-RAKPSYISISPSEYIAAGDV--GKILLYDLSREVKTWAFR-TSKINAISWK-----LATGSL-----------------DTNIFIYS

       LYTE--QDLYR-PALTVT-PDGDLLASYDG-ILQRRSTDTWGEQQV-VSA-PSYLVDTG--TIFNFHVANVATSTD--LTWSH--TIT-----RFAASGIQLAGRLIQQY-----FQ--VSVYSDDRTWRAGEA--MDENKTVELSDGRVLLNSRDSARKVAVSTD---GGH--YGPV--ID--PDPTASIIRARAKVLLFSNASQGTIRMSCD-QTWPVSKVFQSMSYSTLTALPD--GTYGLLYEPG-------------IRYANFNLA

 CNL--AVSELEI-FN--PHGISTFID-VY-------------------------PGSS--VEVFKLHLKT------I------------RHKL------PSVNDIVAVGHFYATNDHKSMGLAWSFVTYYSP-DVRVVAEGFDFANGINISPDGKYVYIAELLAHKIVYEKH-ANWTL--TPLRVLSF--DTLVDNISVDPVGDLWVGCHPGSEVLRIQDIPKVTVVYA-VLQGSTVAA------YKLLIGTV---------------FHKALYCD

CGRHLQR------------------------------------------------HCGVYCLQYDD-QKIVSGLRDIKIWDK-NT-LECKRILTG-----GSVLCLQ-DERVIITGSS------DSTVRVWDVGEMLNTLI-CEAVLHLRF---NGMMVTCSKDRSIAVWDMA----SPDITLRRVLVG--HRAANVVDFD-DKYIVSASG-DRTIKVWNTTCEFVRTLGH-KRGIACLQY------LVVSGSS-------------DN--TI-LWD

    AA--SSRVE--------IVNV--DGVMVAIA-DATAVKYSVD--ATWNTQIAI-ATVIVKG---NKLYILVPLLVVGEVT-ISWG------LK--EFVGGVAIASNGNLVYPV-----RVFTKIMYSEDNTWKFAGRSCSEPAVLEWE---GKLIINNRVRLVYESSD-----M---TWVEALSH--WTN-SSFVAVTKRVMLFTHPLRLHLWMTD--NQRIFDVGQIS--------YK-----------------NDV

         AYHSFLEP-ISCHAWNKDRTQIAICP-NNHEVHIYEKSNKWV----DRAARCVRWEK--KFAVGSGSVISIC-------VCKHIK------STVLSLDWHPVLLAAGSC------DFKCRIFSAFGEL-ESSSCGWVHGVCFSANGSRVAWVSHDSTVCLADA-------KMAVAT--LASETLPLLAVTFI-TESLVAAGH-DCFPVLFTYDSFGGRLDSLHKNSVSQISV----LSQFCTTGM---------------DGGMSIWDV

                     LVNVD--GVMVAIA-DATVAKYSVDD-ETWETQIAI-PTVIVKGN--KLYVLVGILLAVGEVTKWGSPV-LK----Q--FLGGAAIASNGNLVYPV------VFSKIFYSEDTWKFGKGRSCSEPVALEWE---GKLIINTRVRLVYESS------DM--WLEATLSRV-WGP-SSFTAVTMRVMLFTHPLRLNLWLTD--NQRIYNVGVSENSAYSSVLYKD--DKLYCLHEI-EV----------SLVFARLVEL

QFAKSNFDKKVILSNLNKPHALLWGP-DNQIWLTERA---------------------------------------------------------------------------------------TGKILRVNPGSVKTVFQEIVGLLGFAFHPDFPYIYISGTFTIIRRYTY------NKEKPVDLLAG--LPS-GRLVIGPDQKIYYTIGDMGKVLRLNLDGSIPHIYTLGHRNPQGLAFT--PNGKLLQSEQ-------------GPDEINLIVK

       QKALLISPIIREPFVACGPK--ECRHFALTHLVSVKL------KNSIFHMAGSACHDGR--EWTYIGVVKIKYG------EAYTDTYH----ILRTQECNCIGGDCYLMIT---SAIS-CRFLKIRIIKEILP--HTEECTCGFASNK-TIECACRDKRPFKLNVE----DT--EIRL-MC---TYTKGGFVHQRMIGRWYSR-MGMELYVRYDG--LTLSGVMV-GWYSFGFEI-DKDV--CIGIEMVH

                                                        LLLNPDIHG---DRIIFVDDLWEHDL-SG-STRKIVS--NLG--VINNARFFPDGRIAIRVMLN----TADLYFYNGGEIKRITYFGKFTDVAGFDPDG-NLIIST-SMTCLYR--------ENINFVPLNGP-----ATHILFADGRRVIGRNTTRGKIWIE-SG-AFKKIVDMSTH-VSSPVIV---GHRIYFIT------------IGF--GQIYSTDL

                 IPAMCTTS---KGTIVVFADATAAARST--DG-WNK-IAI-PTCIVANGR-ETILVMVLVLYKSTD--T-SKVETNIH-----MLGGSGLLNDGKLVFPV-----LN-TSFIYSTDITWSLPYCEGSENNIIEFN---ASLVNNIRNRRSFETK-----FG---TWTEFPDK--VDN-GSTITIPNKLVAAHSSAQISLYAHNLYSGEVKLIDDFY-GYSCLSYRKNV-ETLYVVYEA------NG------IEFQDLSRHL

                                                                   EYYGFWSGEVRVLGVP--SMRELMRIPV-D-LNGDCHHPHIYDGYLFIND---KA--NTRVARIRLMKTDKITH-IAIHGLRLQVPKTNYVFCNAEFTMFTAIDA------ET-DVAWQVIV--DGNLDNTDADYTGKYATSTCYSDWVVVFNVERFTR-YIPVPKNPHGLNTSP--DGKYFIANGK---------------LS-TVSVIA

                                                                          YLAMRYSDD-ASWSDL-DIVS------VVGPGKQIAGRLLVPL------SK-GFMYSDDDNWTYVEA--TAEAQIVEMPDGSLKTYLRTGSIAEVTSID---GGE-TWSDRV-PL--ST-QLSVINYSKPAIILSSPKNGKIWIGLVSVEWKYSYAVD-YS-SCLAELPD--GQVGLLYEK-SEL------LK-ILKFEKYSI

        SY--HFVGL-HH-VDVLQALCL-ATTS-FSGDLLFYRITIFE-----KKHWALKWGSH---RLVATDTTYIW---SP----LQGTVE-P--SQFATSVDSERGLIATGFN----NG-TVQISELSTLRPLYNFE-NSIRSVKFSPQGSLLAIAHDSFCITLYET-----EF--ERIGSLEFH-SSWVMSLSFNDSETLCSAG-WDGKLRFWDVTKERTTLNM---G-VFDVKFL---KK

                  HDPVM---------------------------------------TREGD------GPG-RA---------AT---EPK-SPSFLWAPDIYQHFYLYYSVSAFG-KNTSAIGVTVNEDKGIVIES--NIA-PAIIAD-VWMSFGSFWGGLKLFKLN--DLTPAQEWHSIAKLER--QIEAPFILRYYYLFASWGLTHLVVGRSKGPYLDKSLLIKG-GLGHNSA--DGKDYLVLHAY-----EA---------------HW

                                                                LP--NLFSVTLQIALVDG----SKKIVKVID-----YAVHISRSASGYLLVIG-------DARIDMIDLPTKVAEIK-GIEARSVESSKEDRYTIAGAYWPPQFAIMDG---ETL-EPKQIVSTR-PEPRVAAIIASHHPEFIVNVK-----KVLLVTVTSIGA-------LHDGGWDS-SHRYFMT------NN--------KTPHPVAVFDL---HDVY

                         CTI--------------------------------------WHIYG-------K-----------DNA-------VTREPYVDPDECRFYALTIHDRSQYRDLISWPLSSPNSRV--IGWSSTSCHDGR--ARMSICISSAVIWYN-----------RRPVTEINTWALRTQ-CVCQNGVCPVVFTDETRIYYFKE-KILKWE-LTAKHIEECSCYG--EQGVTCTCRDN-----------QG-SNRPVIQIDP

          YHF---MNDPNLIFW---GKYHMFYQYNP-HAV-DL--VHWRH--PV--------------ALYP---------------------DDETHGVFSGSVEKDFLVYTYY----GEKETQCVVM--YDGNVISK-AFRDPKVNRSNGEWRMVLGSGKRVLLYTSD--DLFH--KYEGAIFEDETT-IECPDLVR--DILIYSITNSVLFSMGELLNVKRGLLDHDFYAAQTF----DRVVVIGWLQSW-TGL---------VMSLPR--LY

          LVQFH-YNYSALLLSEDKDTLYIGA--REAVFAVNALNIEKHEVYWKYIRVLQPLSATSLYVCGTPACDHLNLTSFKFLGKEDGK-----PF-YTSVMVDGELYSGTG-----SEPIISRNSS---PLRT--EPSFVFADVIRK-DRVYFFFT-IPRIARVCK-GD---SFLKAR-LI--VFNV

                           RDYILAP-----KLVVIDTEKMAV---------------------------------------VITI-----GPTPMVPMVAPRIAYATV--KS----ESLVKIDLGETGRIDLSVKSLFGAALSPDGKTLAIYESPTRVALYDAE----TL--SRRKAFEA--PRQITMLAWARDGSKLYGLG--RDLHVMDEAGTLVEDKPIPDVLAVW-Q-----SGV-MAT----------FYT-------LLT--TG

                                                        IVPAAAAIEP-GRVLMWSSYLTSSWDP---IVSD--T---------FPGISMDGQIVVTGG-------NDAKTSLYDSWIPGDM-AR-GYQSSATMSDGRVFTIGGSW--KNGEVYSPS---KTWTSLPNAKVN-LTANHAWLFGWKSVFQAGP------MNWYYDVKSAGKRQ---AMCGNAVMY---DAKILTFG--QDS---------DA----AHIITL

                  FA-VDFFVSRMFLLVGAP-GGQVLKCDW--RRCQPIGT-GGFSIDFD----VLLGGPGQLIS-IVYD-----LATR-TAFDDSYLYSVAVGDDDFVSGVR---RTLGMVYIYDGKNMSSLYNFTGYFGFSVAATDDYADVFIGAPLFQVSVSLQ-------GDFQTTKLNG--VFARSAIAPLGDNDIAIAAPYGGIVYIFNGNAVPQILEG-PSFG-YSMK

  VAVEWD--HGV-L--ELSDLIVNG---KLYSVDDR-T-VYQIEG--SKAV-------------------ILSDGDG------------------EK--FKAEWLAVKDERLYGGL----WTEN--WVKVVGHENWVNYN-YLIHESACWSDTLQRWFFLPRRANLLLSAS----PDFGDIAVSHVGAVV--HGSSFKFIPNQIIVALKSEASYIMAFTLDGRFLL---IGSVKYEGIEFI

          AL----AVHI-RLSAS--RYLFVIG------NMIDL-EPTTV--------------------------------------EIKIG-----SEARSIETSEDYAIAGAW------PPQYVIMDTLEPKKIQSTRPRVAAILASHYRPEFIVNVKETGKILVDYT------DLKTTEISAER---FLHDGGLDSHRYFITAANAR--LVVIDTKLVA--------QTPHPGR--------GA-------HMGD--DS--GGSLFIKVFDI

               VITC--LQFED--NYVITGA-------IRVYDNKKF------GVWALKYAH----VSGSTDVR----IK----CCTHV-------STVRCLDIVEKYIVTGSR------DNTLHVWKLP--VGVLR-HASVRTVSG---GNIVVSGSYDNTLIVWDVA-------QKCLYILSG--HTDRISTIYDERKRCISAS--DTTIRIWDLNGELYTLQGH--ALVGLLRLS---DKFLVSAAA------------LSAITTNF

                         CQI--------------------------------------FAPFS------------------KDNS-W-----VTREPVSCDKCYQFALGQHDRIPHRTLLMNELGVPFTRQV--IAWSSSSCHDG--KAWLHVCITTASFIYD-----------GRLVDSIGSWSLRTQ-CVCINGTCTVVMTDDTRILFIEE-KIVHISPLAAQHVEECSCY----RYVRCICRDN-----------KG--RPVVD-INM

                                                                    EYMIVTNNNLHVVDVASDTVYKSCVMP-----KFGTAMMAPDNRTAYVLH------GDIYGIDLDTCKNTFHANLRS-YSFAISPDGKEVYATV-NPRLEVFS-------TADKPVRTFPM--PRQVYLMRAADDGSLYVAG--P-DIYKMDVTGKYTVALP-PDVLYF-------RH-EFSMLY-------------------YLS---DLK

        SLGAST--SV-PRVHNCASACL-LFFLFG-AAAGLSVPGASDDQL---ASCFHIHPGAATHYLGS-CP-SLA-SLAPAAAG--AQCTGA-QN--SSQAAQAPGMLVWAV--------ASSILQGTM--AIDGNFRSA-QMVAKLKNTDGIMILTVAAENTSSVT----ASVGQTSGPISNGH---DSDAIIAAQDSDNYANSAGTEVLDIYDAASDQDQSSELD-KGPESLSVQ

                                                               IPW---------------EERP-SK-------RN--ARVFNSAVVPYFVGVFRID-----RPFLHFGRSKNWEIE-I--YAYDPRVVKIED-TYYITFCTPTIGVGTKD------FKTFVRLPNAYVP-FNRNGVLFPRK-YVLNRPSFGDIFLSESPDIHWNHRFVLGRKIGAG-PI--TS-GWLLIYHGV--LTC---------YSAALL-DL

                NPGPGHGITLTNGRLIYPAI---------------------------------------------------------------------------------------FLNVMSIYSDNWQTGSTL-EPSEADMVELQNGDLLLTAR--PRQQFLSKD--GGIT-WSLLENNAN--IS--ASITRFE--FLLFTNPQNLGLWFSFD-VTWKGPIQLVASAYSDIYQLD--SENAIVIVET--N----------NMRILRMPIT

      AFQEHFI-------------------------------------------------------------------------------APT-GSG-CTRIPSFDTHY-CYTHN-CRDHSHSHQYLA-T-----SISLDNRKSCSVSATP--LGCDMLCSKLMAHGRLGF-----DGQYHEK-DLDVTFANYPGGGSFIDGRVWFSVYGQQAILSIKVEDPV-TVPPTLMGAEGRILTV--GTSHFLYQRGS-----------YF---ALLYPMTV

     SY---------GVEA-PVVVD--GIMYVSAS-WSVVHAIDTRTGNR-TYDPQINRVALWKG--KVYVGADGRLIALDAT-GKE-WHQNTFE---SLTITGPRVFKGKVIIGNG--GAE-RGYITAYDTGERWRWFSGGTMWDSMTFDAE-NTMYVGTGN--SIVALD---PDTGKYKWHY--QETP--YTQPMILA-----LH-APK----FVL---------EAPTGT----APSTYMV-QYVSVAVGWG-----RQ-----GPGTVYTFVV

                              VYVNDPAATQQF-IDGEAGR------GFPN-HIFPTDTFFMH----GSLAV---TPEITHVFHPED---EFLINHPASA-RLVWPTY--------TGKIHQIKF-LAVEALGWRPGQQVAYHRALDRIYLLVASRFVVVLDAK-----TGERLAKFEMG---HEIDSINVSQDPLLYALSTGDKTLYIHDASGEELRSVQLGHG-PQVITT---------------------------------------ADM

                GLEA-PLFHD--GVIYTSM-SWSRVIAVDAASGKE-RYDPEV--VALWGD--KVYVGTDGRLIALDKT-GKA-WSQQTTDPAKPYSITGPRVVKGKVIIGNG--GAE-RGFVSAYDTGKLWRFYTGGT-WDSMAYDPE-DLLYVGT-------AIR----DTGKLAWHYQFEA--QSGIVAAPMTFE-------------------------------------------QYVAIMAGWG------------RSRLLVFAL

SGS-HVN-GG-DIELRFGPY-SWANTNADL--LFFQFAPAVG-VVQGGSSD------Y--HIHPGAPSTFYL-----LCKT-HAAAGA----LTA---AQN-LTQPAQASRIVWPVY--------SGKILQATN--PIDALRPGG-QQVAYLKSSDGIYLLT-AAKEVTSVT----GLVGQTSSQISLGH---DVDAISVAQDPDLYALSAGTEVLHIYDAAGDQDQSTELGSG-PQVLSV---------------------------------------MNE

                                                     PNFTA-NVILHE---HHIFLGA-YIYVLNEEDLQKVAEYKT--GP-DNINMALVDTYDQLISCG-------SVTCQRHVFIEVHCI---ALGAKVLSSVKRFINFFVGNTIHSISVRRLK----KDGFMF--SYI-DV--IKYHAFES---NFIYFLTVHTRIIRFCSLHSY---FLLDS------------------------------------KKITKI--PLN

     PIQEHLQLQNPASTLTMES-----KFICIR----QVVIIDMNDPNPIRRPISADSAIN------IALKAGKTLQIFNIMK-SKMAHTMTD-------TFWKWI---TVALVT--------DNAVYHWSQP---FDRAGCQIINYRTDAKQKWLLLTGISVGAMQLYSV------RKVSQPIEGH--FFFPVAMQISEK--VVFLITKYGYIHLYD----CI---IS-GETIFVTAP-----HEIIGVN---------------R-GQVLS

       LMPG-------------------------------------------------------------------------------GL-AMPTVDGCIRTPSLVIIYAYTSNLICQDIGKSYQVLQ--TVNPSHTFNIDNRKSCSLALLNTDVYQLCSTPDIVLDIVNY-----GSISTTR--FKN-YAALYPSPGIYYKIIFLGYGGLMVNSIIVVDLKV-WTISNYW--GSEGRL---GNKIYIYTRST-----------WH--QLGIIDIT

                GHEG-PLVIG--DMMYVHSAFPNNTYALNLNDPG---HKPKQDRLAYGAG--QIVKKQNGHLLALGK-------EVEVC-DPKGSTLTQPFVAKDTVLMGCS--GAE-RGAVNAFDTGELWRAFAGGTNWGWYAYDPKLNLFYYGS------WGRDL---DTGMAKWGY------------------------------------DGKELWNFKMPSGGIGSPMTYSF--QYIGSMYGVGLV-FDQM-----GGGLMVFSL

    PK-YSFY---VA--RG-YAFS---EYFAYG--DWVTIKF-------------VKFSCMAWT-GKGMFYNA-QKLYYH-LGTDQEDILCAEFPDEPKWMG--ELSDGRYVLLSIEGTD---VNRLWYCDLLKWVKLIDNFEGEYDYVTN-EGTVFTFKTN-HSLINID-------FTDPWKVLVPEHEKDV--WVACVRSNFLVLCYLVKNT--LHDLTGALLKIFSVV------SGQ----DEIF-YCF---------SFLSPG-------YHC

        RP------GHEG-PLVVD--GKMYIHTSFPNNTFALGLDDPG--QDKPKQNRGLAYWP---ILKTQLNVAAL-------GETWKVEN--DISTLTIAPYVVKDKVIIGSSG-ELGVRGYLTAYDVGEQVWRAYAGTNWGWYAYDPGTNLIYFGTGNTMTIFGRD----ADT-EAKFGY-QKT-----NVMMLS--KLLTHPDRDGYLKAR-------LWKFKIPSG-----MTYTH--QY-AIYYGVGGLVFD-------MGGGVVVFS

              NIVWDSWPLVAN-HGYHIVFALASIYMFY----------------GSATFTSDGKIRL-----TAQVNVS--VEDYKS-FGDGNVHTLRDPHYVEDKYLVFEA------ANGALGMIE-KVMKPLIASDEIER-NVFKMN-KWYLFTDSRIYMLGYVSNS--LTGPYKPLGLVLKMDLFTYSFAVPQAKNNVVITSYMTAPSFLLNITSVVSILEQG

           SFST-GHEG-PLVVG--DRMFIHTPFPNTTFALDLNEPG---NKPKQNRLAYPL----IFRTQDGHIVAM-----GET-IMENS-DIKGSTLTIPYVIKDLVLVGSS--GAE-RGYVTAYDSGEMWRAFAGGTNWGWYAYDPE-DLFYYGS------GREA----TTGEAKFAYWEKM--ERFSVGTMATAGGLTFYATLDGFIKARDSDTGDLLWKFKLPSGVIGHPMTYKH--QYVAIMYGVGGLVFDQ------MGGGVMVFSL

       LTPASYSF-QRGQE-----------VTAS---RLFALDAKTGKRLTYNH---GALVLF---ATAHADRNFFYV-R--------AFPFVNISPP--------------------FL--------------------GGKNP-MAYSQD-GLFYVPANHGSLRAMD-------PVSGKVVWEHK--EHLPAGVLATAGNLVFTGTGDGYFKAFDAKSGKELWKFQTGSGIVSPPITWEQ--QYLGVTVGYG-----AQ-----GGSFWVFKL

              STLVLSAYV---------FSGS----H----NRDG--WHS---PI-------------------AHQ---------PQGP-------TVDAAFSWEDKLYLIQ--------DT-KVYVNGYPKRLE-SLEAVDAAFVCPGSSRLHIMAG-RRLWWLDLK------SATWTELPWP----KVDGALCMEGPNLYLIHG--PNLYCYRHVDKL-PQPQR----------------------------------------SRL

              CNVIFAIAENQ------LYLFKD-KYWRFS-EGRGSRPQGPFLI-------------------------------DKWALP------KLDSVFPLSKKLFFFS-------GRQVWVYTGSVLGRLD---AQVTGALRSGRGKMLLFSG---RRLWRFDVK---AQMVDPSASEVD---LDTHDVF-------AYFCQD--WR---------NQVDQVGY------------------V------------------TYD

            YQ------------GTYP----------------QNK------------------TLI--WSN---------------------------FKFLFSPGGELYGVLN-------DKIYKGT-RAKKIG-GGWNQFQFLFFDPNG--YLYAVSKDKLYKAS------PP--RATEVGSGG---GFKFLFFHPNGYLYAVH--GQQFYKALPPV-RATKIGGGWD---FLFFS---VGTLFGVQG-------------------YPPS

                EESA----PNGT-------------------------YA-YLCGTWVTEE---RISLQSIIDIC-----------RQHIEISWVGPAE-HFTSDGNSFYKI------YKHICHFQT-DKSNCTF--EVIGIEALTS----DYLYYISNELYRIQLN--------DYTKVTCLSC-QYYS-------------------------------------------SFSN---KAKYY--------------PGLP-----LHSSS

                EESA---PNGT--------------------------YAYLCDVTWAT----ERISLQSVMDIC-----------RQHIEMSWVGPSEPHFTLDGNSFYKI------YRHICYFQI-DKKDCTFTKEVIGIEALTS----DYLYYISNELYKIQLS--------DYTKVTCLSC-QYYS------------VS------------------------------FSK---EAKYY--------------PGLP-----LHSSV

        KPALVSIPE-----------MHTVC--KS------FG---MVP-----KVVQVSA-------TAALGRVFL----SMV----PVQV-QLDVPVVKVASGN---DHLVMLTA--DG-DLYTLG-----LVP--CVRQDAFCGA-------YFTFAISHVYGFGL---------FIPQN--SFKNKSWVGFSGG---HHTVCMD-SEGKAYSLGR-SIPTLISLPAV--SSVACG-----VGYAVT-----------------KDGRVF-AWGM

              PSLSLDAIT---------IFKD--FWRLH-QQ----VDAELFL--------------------KSF----------WPELP----N-RIDAAYESHDLIFIFR-------GRKFWALNDILYPK-ISVKKISAAVHFED---GKTLLFSGNQVWRYDDT------NHIMDY--RLI-EGDKVAVYEKN-GYIYFFNG--PFEYSIW-----NRIVRVMP---------------IL

                             IVVMLT-KKGFLKRLSQN----DL----------DY----LFMISNEGKLYLIN--LIN-GVIVIK----KDFVTSAEIVF--------------------------------------------DEKVICLSKKGSAFIFNSR----DV----------KE-----------ENPYLLIVSE-GYGKRLNMSK-------------DAI--------DEILLVSK-------------RSKALRTV

    PRSAVVAEPELGLGPLHTAFDG-RGNAYTSLFLDSQVVKWNIE-------------------------------------------------------------------------------------DA----------------------------------------------DPIKDKLDV--HYQPGHLKTVTNDWLVCLSKFSENDQLIDI-MVLVHDGPTFAE-PHDAIAV-PS

         QSALKG------IAA-YH--SLAL-------------------KDGSGVDAIAAS------YALKDGKVI-------------QSG------VTALDGGVY-TALAVK-------NGGVIAW--------AQSGVDDVAGGI-----FHSLALKDGKVIAWG--------------VPTALSG-VSAIASGE--WYSLA-L--G---IAWGSS--TAPVALKG

             CDSKLTFI----------LMF-KD-FYMR---SFY-PEVELNF---------------------ISV--------------------------------------------------------FWPQVPN-GLQAAYEIAD-DEVRFFK--GNKYWAVR-----GQDVLYPK-IH--STV-IDAAVFEETGKTYFFVA--HECWRYDEKQSMDYPKMIAGNKVDAVFQFD---FK----------------------ANS

                                                                           PEIC----------K------------FDGIAQ-GEIFFFKD-----------IWRTPMGPLLWPELPEKIDAVYEAPQEEKAVFFAGNE-YWIYS--------ASTLEG--PLT-PDVQDAAFNWSNKKTYIFAG-DKFWRYNEVKKKMDPFPKLAPDNLDAVVD---G----YFFKG

                                                                                 LR-TTLSSGGAGS---------------GLFP-----------------------------------G----------GLDKTTLLEIPRR-N-PQDGPGYDLFILDDSGAYASSFIGYPEAAYYVAGAATPDEIIFILRAGWY-CEIG-LFDSVDYFAY----RGVMFIGSAR--YTE------LPI--KYRAII

                                                                                                NTGIVSSFFT-----DEIDIEF---DTTKVQFNYYTNGVGGHEKVISL--YAFDWQ--PGYIKWYVD--GVL-T-TA--NI---------------------------------------------------------DWVKY------TGGSFFEPF------------NDGK

                                     AEYR---------------------------------------------------------GIVSSFFT-----DEIDIEF---DTTKVQFNYYTNGVGGHEKVISL--YAFDWQ--PGYIKWYVD--GVL------------------------------------------------KHTATA------------DWVKYTS----TGGSFFEPF------------------TNDG

     GRP---QRDYRIR-----------------FWV-----------------SH----------------------------T-RNS--------TRRMIIGQI---SLVKLLYQL--DQGRVQALVRPD-GGTRAYT-MD--YRIGVSRSGLLSVSV----NGSALEQQLDQW---------------------------------------------------------SELRVSH

                         IAG-TN-----------VTGD----------------DVL-----D-I----N--------------KSSFKRGKYVVCF--PL--------RKN------------------------VAAGYALYGS-ATMLVLAMVNGVNCFMLD-P--GE-ILVDR-VK----------MVA---DVH----------TL---VYGGIFMPA------------------KLRL-IV--------------RAP

                 DGFVINLGQ--LNLHFNPRFSTIVCNSLDGSNWGQEQREDHL---VTFESDKFKVKL--DGHELTFP----------------------FKLKE

            ACG--KSFVLNLGK--LCLHFNPRFNTIVCNSKDGGAWGTEQREAV--V-ITFDQANLTVKLP-DGYEFKFP----------------------VAFD

                                  LVQT-------------------------------------SDPG-------------------DDDYAGFVFG--RFYVVMW-------SGLSVKVVKSQVRTLWHHIG--WRLSHRPKTGFIRVVMYEKI--GPIYDKT------------------AG--YECRDP

                KSFLLNLG-K--NLCLHFNPRNTIVCNSKDAGAWGAEQRESA-VC-ISFNQTDLTIKLPDGYEFK-P-----------------------VAFE

           EP-QSGV---------------LQL-TKRTLYAK--------------LV-FMGPTKSK-----GYLGI----------NN------------------TLGVEFD-------VPHIGIDVNSIRS-KTQPFQL--VVIKYDAKILHAVLVYSGAI--IAEIVD-------------------------------------------------------------YSWSF---------------------------------------QA

            PVD---------------YVP--QLH------------------TGTG-------------------------------------AGTVTAFYL-----DEIDFEF----PYILQTNVFTGGKGDREQRIYL--YSVLWN--MYMIVFLV---DDVPV-KNCKKF---------------------------------------------------------RSFHIDG---ARW------------------------------EFQ

                   GKFLTVGG--------------------------------------------------------------------------------------------NNSP-----------------------QRFSVNVGLSLHLDHRFNQNTIVMNSTLKGDNG---------------------------------------------WETEQRSTNFT----LSYD--INKFYIDI----------------GPNLEF-PNRYKEF

                                                              DVV------FS-------------------RSSGYSGNYIVVFDP----------SPN------------------------LAAGYCMYSS-SVIFVLTIGKGVYAFTL------GEFVLTS-KIQ---------LVG---DFH----------TL---LYGGI---GHQRIL--------------------------------IQPRVPL

           HQ-SNSV---------------LEL--T-----------------NSTLVFIAPPNTQT-----GYFGI----------N-------------------FVAVEFD-------IPHIGIDVNSVIS-KTVPFTL-NVVIKYDAKILHVVLVFLGTI----DIVD-------------------------------------------------------------LSWSF---------------------------------------SA

           EE----------------ELN-------QAS--------------STGLT-FMVPPNS------GNLGV----------FK-------------------FAVEFDT------VPHIGIDVNSIVS-KTLHFQL-NVVIKYDSKILNVVLAFVGTV-TLSNIVD-------------------------------------------------------------ISWSF---------------------------------------TS

                                                                                                  GIVSSFFT-----DEIDIEF---DTTKVQFNYYTNGVGGHEKVIS---YAFDWQ--PGYIKWYVD--GVL-T-TA--NI-------------------KYTSNASGG--------------NYS

            FSP--------------NLI-------DGY--------------TVGFT-IAPVD-TKP----GYLG-----------FN------------------TVAVEFDT------DRHIGIDVNSIKSVNTKSWKL-VVIAFNAA-NVLTVSLTYTS---S-DVVS-------------------------------------------------------------LSWSF---------------------------------------HS

                             SFI-------DAT--------------SLGIA-LVPVGSEP-----GYLG-----------FD------------------TVAVEFDT------MKHIGIDVNSIKS-ATVSWDL-EILITYNASLLVASLVHRRTS----ERVD--------------ELPEYV--SFASEPLDLYLVL

             NY--------------------------TGL--------QKAD-------------------------------NGNM-------GIVSSFFT-----DEIDIEFG--DTTKVQFNYYTNGVGNHEKIVNL--YAFDWQ--PNSIKWYVD--GQL-T-TT--QI---------------------------------------------------------NWVRYTKR

             SY---------------------------GT--------EKAD-------------------------------SNGGV---AN-GIVSSFFT-----DEIDIEFG--DTTKVQFNYYTNGVGGHEKVISL--YAFDWQ--PGYIKWYVD--GVL-T-TA--NI---------------------------------------------------------DWVKYTSN

           NP----------------NLILELT-V------------------DSLLA---APPDTQP----GFLGL---------ADR------------------TVAVEFDT------YTHIGIDTNGESKKTTPFDMV-ANIVITYQALAASLVF--SQTSAVSARVD-------------------------------------------------------------VSWSF---------------------------------------AV

       IST--TRFV----------------------------------------------DVL-----NDM----N--------------KSSFKRGKYVVCF--PL--------RKK------------------------VAAGYALYGS-ATMLVLAGGSGVNSFMLDP---GEFILVDK-VK----------MVA---DVH----------TL---VYGGIFLP-------------------KLRL-IV--------------RAPV

           HTD--KV-----------------FVFDHVNLI---------------LFSYNTQ----------------------------------------------LLVYK-------VGEYSLYR------TSKVIE--ICVSWESSSGIAEFWIN--GTP-KKGLRQ---------------------GDWDS----VL--AYQGTPL-------------------------------NILDW--PLV

             NSN-TRFSINVGE--SIAMHMDHNVLVLNSLVHNVGWQQEERSKK----ITFDTHTFYIQLNGETVEFPN---------------------------------------------------------------TFVRL

                             SFI-LRL--TK----------------SLGIAALVPVGSEPK----GFLG-----------FD------------------TVAVEFDT------SRHIGIDVNSIKSIRTASWGL-ILITYNAA-SLLVASLVHTS---YIERVD----------------------SFASK------------------LDIAS-RN

                     LRFKR------------------------------------------------------------------------QPEGILLFA----TWIVLAL-----GRLELQLRYNGVGRVTSSGPV--ISVEEL--ARNLVIKV---NRD---AVAG-----------------------------------------------------------RSWNWLTVK-----------QCFS

                AGVVVEGTN---DRWLATILWKFIDVVKTTQNGSYSQYGPLQ-----------------------------------------------------------------------------------STPKLYAVMKHNGK--YTY-GE-------------------------------------------------------------------------------------------------------TP-----TKYYSTTNYD

    ITS---------LMGA-MLYYATFATLHYTFTDESIVIEPD-KT-GITIHRKTIGVMTNS---------------HQ------TNLLRYWKKYEKA--------------------ET--TNLFSSV------------------------------------------------------------------------------------------------------------NIPK-GVVTDYTSA-VSL------------------TFE

           SQ-ET-VL---RYIAP--------------------------------LT-LAPPDSPL-----GYFGL----------ND------------------TVAVEFDT-------PHIGIDVNCVKS-NAERWN--VEIIYEAS-KTLTASLTYTS-----SIVD--------------ILPEWV-----------------------------------------LNWYF---------------------------------------TS

            DNPN-VF--YKVKES-----------------------------KTIISQHHASDTGTSKVYVVYVR-----------EEKFA--GTM---LRVVNNYGDVEVTA-------FGNSFGIPV------------------------------------------QS-----------------NVTYTR-----------------------------------------ETN

                            EEVIVGR-----------EGVTVRRP---------------------------------------DPIDWSTGLYAMPR-----------------------------------------LIVV--GNEIIEAPMA-------------YFAKWTAP-----TE--FDADFIRAGRDIFAQRSQ-------YR----HIISFKDPNPMHIDNII---IVLSN----------------------DRPC

           VP----------------DLL-LQL--TK----------------SVGLA-LAPPD-SQ-----KYLG-----------NN------------------IVAVEFDT------YRHIGIDVNGIES-KTVQWDW-ATITYLAP-KTLIASLVY------------------------------------------------------------------------------------------------------NQTTFSVA--ASVDTS

              SS-GQL--FYSAP-----------------------------GL-AFALVPVGSQ------GFLG-----------FD------------------TVAVEFD--------RHIGIDVNSIRS-KTTRWDENVLITYDSS-NLLVASLVYTS-----DTVD-------------------------------------------------------------SWSFA

             VS-TVSSFLYQ----WVEVDIEVGSFQSNIITKAAQKTSEKHHAV-YGLEWTPN-YVRWTVD-GQE------------------------------------------------------------------------------------------RKTEGGQV-------------------VKVYKYT---------------PG-----QGE--------------------WTDNF----------------DTF----------GK

          VF-RS--SGRTGI-----EDVPVESYSGNY-------GSIFGIYSPND-----------QR-------------------------------------------------------------------------LAAGYCMYSSSVIFVLTI-GK-GVFVFTLDPG-EFVL-QENLQ-----------LVG---DFH-----------RT-LYGGIYGYP------------------KLRLLPT--------------IHQRPL

           VP----------------NI--LQV--TKRALAA--------------LA-LAPANSQI-----GMFGL----------SS------------------IIAVEFDT------FKHIGIDVNSIKSIKTVKWDW--VVITYRAKSLTVCLSY-GTS--NIASVD----------------------WYFTSN

                 KGFSVNVGK--LMLHFNPRFNTVVCNSKEDGTWGEEDRKAD-IC-ISFDAAEVKVKVPEVEFE--FP--------------------------------------------------------------VKAIK

             QLALFKSSPEPVALTIRCTKHTFTDHMVFQFDCTPGTCYTLVALP-----------------TAVACTFSC------------DL----HIQ-----------------------------------------K--------------VMKL-----------EAV

       LLPVP----EPYLQVDF----VFHFQVCFGRRVVMNSREYAWKQQVESKNMF-LSISVLDKYQVMV---NGQSYTFD--------------------------------------------------------------SLTKF----------------------LK

                KGFAVNLG-E--NFLLHFNARNKIVCNSKEADAWGSEQREEV-VC-FEYQTQKIIIKF-SGDQFS-P-----------------------ITTE

           VP----------------NM--LQL-NK-----------------SLGLA-FLAPIDTK-----GYLGL----------FN-------------------VAVEFDT------NPHIGINVNSIRS-KTTSWDL--VLITYDASLLVASL-YQRTS----DVVD----------------------SFASLDLT

                               PRD--SRFLES--------YK--------------WLS-----------AP----KP----------APAG--NVLRFGTDLLYLV---------------TVHPC--KLYASTST-IVPLR-PGLVLTNP---------------FLRS-NIT-C-PEL-VDGMNLLVVRPDLAVV-------DR-----LE--LPLQL--THSGGFHDV

           PS----------------NL--VQL--TK----------------TVGIA---APPDTT-----GLLGL----------FA------------------VIAVEFDT------YPHIGIDVNSIRS-KTVKWDR-NVLVTFNPRNLDVVATY-GTR----YEVD--------------VLPEWV-----------------------------------------ESWSF---------------------------------------TS

                                                                                                                LYHLF---------------------------VN--QVK------------------------------------------TTVFNFLSAGNILLHISIRVIVFNSRLKNGAWGPEERIPY------VIDH--GDRFQIRFD---------------YGTSIY-YNKKEN

                                                              AS-----GEI----QG--------------ILRT-GPEKRIAYLGLDPRRFRVFIDVSGAR-PQEVTVSVTNGTVISAVEL-------------------TAATG---------------------------ELP---------------------------------------EE---------------FEVVEQ----VRVRGRR

                                                        KA-------------------HNA-------------PP--E--PDVFVE---------------------------------------DP-VLCT--SRCAIITRPG-------------FYPGVERI----G-----GDIMMVGDHF-YIGESA--------LE---SVVRL--EKVLHLKLAY--HNNLLA---------------------GEFVSQDF----WVN

 YLFFV----------------------------------------KRSIPSCF--------------------------------------------------NKRD--KHLV-----------------ADS-E-ALLQ-----------------------------------------------------FKEVWQVIGIYRLCLTSK-TISFVKLNSEAAAVVLQLM---------HSE-NFFF------------------------IEEFWMQVDDSV

              NASRFHVNLL-----ALHFNPRLSEVVFNSKEQGSWGREERGPG-VLIIASD-DGFKAVVG-DAQ-HHFR--------------------------------------------------------------DSVR

        TFWDGC--------YEARI----------------------------------------------------------------------PG--VSPAFW--SEIDVVEL-------RESDHDLHN-RPGHNGYHLDP-TYGVNVTKDKITWYV----DGEIGEKDNLY--------------------VRTWVKV

           HT----------------KLILQLT-PR-----------------DSLLA-LVPVNSPP-----EFLGI----------NT------------------TVAVVFN--------NRIDFDKNFIKP-VNENCDF--VQITYDSNDLRVFLHFSQVK---SATVH----------------------WSFSS

                                                              LS-----AEIK---TN--------------TVKSAGKKISFNTVTEPPRLAYYVILEA-KPGVKEGLVDLASLSVIETRALE-----------------VQ---------------------------------------------------------------------------PI-------------LCSTEIRVYC

                                                                                                                          LL-----------------VQ--------------NGSH------P------------KDLP-----ARS--GVSFFLVKVPRLLGITK-ECVMRVDEKTKEVIQEWSLT---------AS--KSFT-------------------------LDYYSVQTTE

           AP----------------YLI-------DAL--------------SLGLA---APVDTQP----GMLG-----------FK------------------IVAVEFDT------GRHLGINVNSIESIKTVPWNW--VFISYEAKSLTASLVY-TS-----AIVD-------------------------------------------------------------LSWSF---------------------------------------ES

                             AIN-IQL---RVLYAM-----------GII---IAPED-TQ-----GTLGV----------SD------------------FVGVEFDT------TDHVGIDVNSVDS-KTVPWNS-KVTVIYDSKTLSVAVTNNGDI----QVVD-------------------------------------------------------------RSWSF-LI

            SHAVIETF------------------VLHIAPV-------------TA-------------EMP----------------GA----------FA-----------S------GEVDVA--------TRT-REYDYVYLPP----GVYWGNEREN-----------------------PGYIAR---------AFFMVSTM-------AE----------------------------EHGLLM-GEGL-----YKL-IWMGA

                                                                           FA------------ISFDAWEM--ITLPPSA--------------WKVTYINAYGPTE-TICATTWVAKTGDQARWLSDGNIEYLGRID--------------------------------NQ---RVE-EVILLKHM--------------------YISETAVSVHK--YLCAYF--VS

                                                                IA----MEYHNAV---------------------TKS-----------------EKA---LQSNHFEL------------DYIALAIVDG-FVQMMYDLGSKPVVLRSVPTHIKQAPITGS----------------------VA------HKLP--------------------S----------------------------------------TGFIGCIRD

                GGGT--QLQSDLLRV--------------------------------------DIISWG-TITA------FA---GAVI-HGGGFVLWTPRVLSNGVQFSRS--PDGELKVWVTYTLLIVNYRAQA-TQ--------------------------------GF---------------NW------------PDAVN-------------------QPRF

                                                                                                                                                   DKLIEFD-------------------LNT--------------------F------------LTAINGIVTWFDFSTGQTIFYFDLDTIEGELVNEKN-NIKISYKFESNGID--R-----SRKNEGSYLM

          WSY---------------TEIT-------ATR--------------SS-LA---APVDSSV----GFLGL---------FRH------------------VVAVEFDT------YPHIGIDVNSIVS-ATTRWE---AHITYDAKILTVLL-YGRD---S-HVVD----------------------HFFSTL

                                         QVRG------PWN-----------------------------------------------TFNK--------------YLCL--------------------RQD--------------R----LP-----------------------KL--GVDLHKAKVDIILGVCS---SGLLVYKDKLRINRFPWP---------YKRSSFFI----------------QE---YES---IGFKLPS

          WS----------------DSI-LQL----RAL---------------LAFFL--APPDQVVAVEFDGINVN------SIVSVATKRWEDI--ARISYDGAEILTVVLS--YPDGSDYILSHS------------------------------------------VD--------------------WRFSSN

                                                                                                              IVAVELD-------YPHIGIDIKSVRSKKTAKWNM-TAHIIYNSKRLSAVVSYADSAT-SYDVDL-------------------------------------------------------------LSWSF----LHFMFNQ

          PFW--ADQ----------------IR----SV-TKT----------------YTEN---QGL-----------------DGPVF----------------GVGIFF---------PAIVVVGNNY-G-SCQRDF-VRAKITYYQKTLTVMINNGFDYEFAKVENM-----------------VI------SA----------------------------------SFLTF

                                                              LT-----ADEI----KQ-------------EIVK--------------------------------------------FKPNTRFTEISLLPRKADVIMLDGKHIIEAVVDLQ--NKLLSWQP-IKDA-------------------MV-------------------------LL----------------FAVQ-V-ISY

                    ELNFEALRD-----------------NVRSLLGRVILS-GGQTLTAPL-------------RLMILQFRH----------QSLMCRHLPDGGKLTLTN-------FHFTRYHQGHAVEQVNVP--------------------VPYQQQ----------------------------L--------GV------KHG----------------FT------------------MAAF

         LAVTIVQLAFHYIGLDDPPRKIFVVAISQTHEILINLRIRSIVSDNIHN-----------------Y-------------------------GFPI-------------RTVRL

                       KT----NLSLLL---TN----------------DSMLA--VPVGSRP-----RYLGL---------NTT------------------TVAVVFD--------NRIEIDVNSIRP-ATESCNF-AEVRIT-DSDLRVSLLYSEEK----AT-VP---------------------WSFSSN

                                                                                                                                               PRM-----------------------------------------------RIALDFQR--DVAFHFNPRRVIVCNTKLDNNWGREERQSVF-----VLVE--PDHFKVAV-----------------AHLLQ-YNH-LN

   RNFPLT--------------------------------------------------------------------------------ISE-----------------------------------------WQ------------------------------------------TDRLE--HEDYALGKDCIMHGYMSWQRRYFYLF--PNRLEWRGEGEAPQSLLTME---------EIK-KC--------------------------LKIQFVLQCDS

    ESNSKIN-----NNEYTIINCEN-SGWKVSLNYGEIIWTLQDTQEIKQRVVFKY----------------INRWIFVTIT-------------------------------------------------------------------------------------------------------------------NNRLNNSKIYIN--GRLIDQKP----------IS-HAS--------KL--------------------------------RDRY-IWIKY

                                                                                                              IVAVELNS------YPHIGIDIKSIRS-STARWNM-TVHISYNSKRLSAVVSYSSS-----DVDL---------------------WSFTSKL-----------------------------------------NLHFSFHQ------------------FS

                                                                                                                                   VAPPKEDPVPL----------PE-YFGVAPLVEELY--------------PEKLRYDA--QQKTMVRFSRKTKQQYVSSEK-TGWSAFYVDGKWVEGKK

    NND---------TNEYSIISS---SGWSVSLKGNNLIWTLKDSAGEVRQITFD----------------LANKWVFITIT---------------------------------------------------------------------------------------NDR----------------------------LSSANLYIN-----------------------AIVSI---------EIELYT--NPL

                   SSKAVTR--SVLKDD------------------------KT-------------RQL----------------------PHTLMSFAG----QVNVLIGGKKP-ELYQIDY-------GTKVELPYGAHGY--------------------------------------DHH-------------------LKLQEL------------K-------------------DFKGVKD

            QT--AF--------------VFPK--SYVSLK---------------IFSYATK----------------------------------------------ILIFW---------GYSFT------LFEVP----ICTSWESASGIVEFWVD--GKPVRKSLKK------------------------------------------------------------NVNMWD------NVLNW-KPQL-----------------WP

                            NLVSLSY--SY------------------LDF--------DTVTVEFISIDVN------NNDIKSV-PWDVH--VRITYNSTKVFSVSLS--PSTGKSNNVSTT----------------------------------------VE--------------------------------------------------------------WSFSS

                                                                                                              IVAVELDT------YQHIGINIKSIRS-ATTRWDV-TAHISYNSKRLSAVVSY-GSS--SYDVDL---------------------WSFTSKL------------------------------------------LHFTFNQ------------------FS

             WDI---------DVFG-------------RLAQTLELGVD--------VLK------GFNKFV---------------VQ-----RILDH--AI-------MYVMYWT----------------------VGIRPMYKWTPIMSTVMEIGYKITLAQQWQAG-SRPAIRVFA

                PNLYFT---------------------------------------------------------------------------------PFASVG-NGVTIHY-K-------------NTPWYY--LKLS-EGGDVFIYNNDTLVVG-ER--------EF----------AINVPK--WTMH---MLDKDKFLYS------------------PIA-RETHGTNYLAI----VVI------------------------GYS

                                                                                                                                                NILEVGTG----SG---------------------------ALEIV-----VIIVTA--GG------------------------------KLIIPVGSYHLWQELEVRKTK-------------IKIKNHGGVAFVPLIGE

            KSNF-----------------------------------------KVVGEE-----------------SSSG-----QI----------RFWCLDP------LAL---------------------------QLGCIGCPNLFGYIFRAVRGLGAFYSPSS------DAESWTKIH----------QA-----KY----------LA---LG-ADVYDAM-VPL----------------DF---------------LATKGV

                    GQ----------QGPIAET-----------------EQV--MLAAS------LT-----------------------AELDFY----LFEIGFNLGYA-----RFNTSILVDKSGKIVGKYRK----------------FIC---NDR---------------ETW---------Y-------------TPTH-TSFLL-QAG-----------MLLGHLT-------TTLE

                    CQ----------MTSDND------------------EKNF-MIEGE--------YMEKY-----------RE------------------IWLSLGLH---HPW-NTHLIIDSDGVTRAEYNK-----------GRLGLSI-C--YDV----------------LS---------SA-------------FTLNTGWET-RAR-----------QSYGHSQC------SE

                   NGVLFENQLLQIGLKSEFRMFIFYGNKTGGAQVQQVVNI--------NVSVKLPIT--------------------------NK---------------FQPT-----------------------------------KH-TKA---------------------------------------------IGF-----------------------GSALLEEVDPNPANFVGAGII--HTK--------IGCLLRLEP

             SNW-----------------------GGAIL----------------------------------------------------AA---GTAWVGI-TAILQTGF-------YDAWYE--------EVSITIIQMSVTATSDTSGSATLENLQK-SKSFSNESS------------------------------------------------------------DCSVT-----ESVS-TT

                                                                                                            VTPLSLGIE---STSAVTIHVLQGERDNKSGQFNL-IEVTFDIDADGILHVSAKDKGKE--ITIKASSG

                                                           ILNLRYKD---LSG-----------------KVEVY------------TQ-----------------------------------DFSVSFWIRI---------------------------------------EYTIINC---SGWKISIRGNRIIWTLIDNGKTKSVFFEY-------------------------------DISEYINRWFFVTITN-DIQFIWMKY

  FLA------------GAYVLAGR--GDYTGRLVLK-EVTMTLDFADGS--------------------------------------------------------------------------------------------RSFSGTGRILGAGEWRATLSDGVTIRQIFALQ-DGRFSGRWHD-AD---------------------------------------------ESAGNG-------------TVLKL

              QFVQYD------------YSYLQ-----------TEKLAIF-----SYL--------------LNKEKLLV-----YAYI---YNGNQLQAVY-------AIFY------TAGKLSVA-----EIETDKPCAVLIKH---NGKQVIWAAD---------PL----------------------------AVLSIRD---KTGKTNRVK

                                                                                                                                                                                            VDDYYDTGEELGSGQFAVVKKCRGLQYAAKFIKKTDVILILEL--------GELF-PENIMLVNYEFEEYFSNTSALAKD

                                                                                                                                                                                       EATLI-----GEGVRYKAKQKIFLTISF-GGIKIFDEKTGALQHHHAVH--EISYIA-KDDHRAFG-------------------NHRF----VAIKTAQA

                                                                                                                                                                     SVED----------------TFTV-KRYQNLKPIGSGAQGIVCAAYDRNVAIKKLSR-DVYLVMEL--------ANLC-PSNIVV----------------------K--KIL

              KDA-----------PGDRTLT--DPTYLVVESDKTLAFGINAVCVPFNAAE----NKFICPCHGSQYNNQ-GRVVR

                                                                         ETQH-----------------------------------IAD-------------QV-------SQLEKFPVFKAVSFKSQNYFIKVHVGDEDFVHLRVFQSPLTLSNYQTNKA------KH----------------------------------------DELT

                                                                                                                                                                                                 EQSICQAR-GFSRVHIYHH-FRVVGRKIQHQVVINCAIP---------QATQTFH--------------------------WRYGLNFSKE

                                                                                                                                                                                                VAIVKEGWLHRPRYFLLKND-GTFIGYKE--APLNNFSVA---QCQL--KTERNTFI----------------WTT-------IERTFHVET-LKK

 GEPKPIRL-------------------PGDPFVL-SGTLLVAR------VVAYSAVCVSQWVAD---EEAALCPCHGGVYDRHGAQVIAG

                                                        TK---EGV---KVWTLTEG-TMSEVYADTPNTRE--LQF-AVQRESRTVELAKALSYRQTTTDNAGR-WRLTKTYVTVMLGV-TFE-------------------------------------------------------------------------------ALVSS

                                                                                                                                             PSSALPVTAYDKNGFRILFHF--VVVVSMLNMA----PAAITQV--MLLANP-------------------EKVRLRYKL

KKTLLKRS--KAGTPR---SVQINFFQDHTKLILCPLMAAVTYID--KRDFRTYRLS-----------SRYAR---------------------------------------DKLL

                                                                                                                                                                                                 EQSICQARA-FSRINIYHNTFRVVGVKLQQQVVINYSIV---------QATPTFH--------------------------WRGLNFASKE

                KYVLVELQGSN-KKTITLMLR-VMGYSDP--TNKCRYHIFDS----LDSNGK---------------FTEKA-----------------V--------AAR---------FKYI-FNPN

                 EGSHP-------------------------------------QTLHAAQSGCRAVLQSDGLLVILTAQNTI----------------------------------------------RWSSGTKGSIGNY--------RTVTIYGPGL-------------NHPQ-------------ATQSL----RLSMETD---CNLVLFDRDDRWSTNT---KGTGCRAVLQPNGRMDVLTN-----------------QNIAVWTSLA

                                        DG-------------------AEIV----TIKPYG-SIFE--------NRAILQD-HFELGDFPYEYEIENGVKLWRG---KIPARVEKKIELFIAKYR-------------------------------------------------------------------------------------------------------------------VLLEKPY--KA-FG-EFTV

                 DDNHP--------------------------------------QILH-----------------------------------------------------------------------------------------------------------------------------------ATESL----RFIMQTD---CNLVLYDNNNPIWNTG-LG--NGCRAVLQPDGVLVVITN-----------------ENVTVWQS----HYLVLQP

             WDI---------DLFG------------VRLAGVLELGVD--------MLK------GYNKFV----------------------RILDH--IS-------MYVMYWT----------------------VGVRPMYKWTPIMSTLLEVGYKITLAQQWQAG-SRPAIRIFA

                                                                    DLKE-----QF------------HDLTELNGTTKWEALQ----TGLVMEANKPDLAQTVVIGVALVISINVPL-------------------ASN-------------------------------------------------------KELP-----------------------------------------------ARHAQL-EMVR

                                                                                                                                                                                      TDEYLL-----GDGVKYKAKQRIWVNISL-SGIKIIDEKTGVIEHEHPVN--KISFI--RVTDRAFG-------------------QHQF----FAIKTGQQ

                KKCVTMSSAVVQVACLVKDNPQRSYFLRIFD------------------------------------------------------------------------------------IKDGKLLWEQEL---------------------FVYN-------------------------------------------------------------------------SPRGYFH--------------------------FAALNFANEE

              EI-----IETT----AKVRVLWDYLYVLAI-----------------------DSVEIFI--DAQFRVNYMNEQTFGTG-----KTI-IGFNSDPTNNS--------------------WRD

   GRL-DTYVEMNL---------------NVRQ----FV-----------------AGGT---------DGSSKT----------------------AIASYGVA----------AMLAAT----------------------NLRLIQAINQNFALAYEGSYKLTFAPTFKVGSIRPEIRFYT

                DL-RSSRDN-----ALSITSDLTIRLEGGVEPNKPVRYSYTR------------------------------------------------------------------------------------------------GSWSLNWLVPNIKVFIHELNAGNQLSHMSPI---IEMGELL--------------LAR-DATFF----------------SHAGV------VVDQ--AGN

                                                                                                                           KVQ-VTN-------STVLDIPERGVSEPTEDGYTQIKVTGK------------------------------------------------IAWRFLLNPENKVFFVAIDLL---------------------------------ASPKE

                                                               PA----KRR-----ES------------CVKLNGKCGYVQLRSGQLVGTALMIFCKESC---------------------SIKVEGTVKKT-GAVAIRFDYTG-LCFISHL----------------------------GLRFR----------RG--FN

                                                       THGT----EH----SATRID-------------------------YYDG----PY--RFWGR--KL----------------------QTLRSGLEQGKRITLSPRNYWSTHERYYT-SGQLPSSS---RDTRSGT----GTRYDDG----------------------------------ETQAR---DLSIYASYAYVNAELVPFS----PKHKGTL

                   FG-IAFD--DFATV---------SYD--------MI--------------------WHKIKIVR-ILYV--------------FKLGV---GMGIEM----------EKLM--GAGRFTIYDAHMWHKVTAKKIKNRLELVVD----GNQVDAQS-------------------------------------------------------------RSLKLT-----GKPLEV-VSCP

 DDGN------STVS-------------GEVRLGR--------------SAFRNWA--------YD---GPLSASLLA--RDE----------------ITLGASYN--LSGLLQQ---NS-----------------------MLGASAPVGGVGEVKLQYAHQITLGYVHN-SK-----------------------------------------------------------------------TALYGNLAFLKN-TLG--LQAGVQVGIRHA

                       APLSIVD-IGALDKF--------------LNIR---------EVVT---TDANGEQ---FD---------TEQTLKEVNVGTFPFDTTGLVKVIADAKTDRVLGVHVIG-----VQQGGTSA------------------EDMMVF-TL-----------------------HAIH

                   RP----------VP----------------------------PWTN-----SHN----AGG-P--NAFDRPGHYVYLR--YWSI-----------------------------------------EAQYQIRHGLSYSKFQCDYNGIHARKTLF------IWDVVI---------------------------------------------KNTS

                                                                                                                       GGKDG-RPD--------------------------------TA-GNYPAW----------------PEVAGRH---AFGIHRWQDKMVTLKASHGVAQIVSNG-SQ--EGAT-----GT-G---------MMAFN-------Y--NFTA--KKSV------AD

               DKG----------------LVLM-ISAK-----------------VKLLSKTEL------------NL--DQFHDK-------------------TIMFGPD--------YKLHFIFR-------------------------------------------------EKHAKRP--ADL-YTLILNPDNSFEILVD--QSINSGN

                                                                                                                                                MTMNITS--MEIT-----------RQ-------------HDRLKLEKWQTHPHIILSKFVADATINTPNGVLVASGAININKL

         SR---PKA-HLD------------V----EVVIVPFSLI-R----------------LKKLRVVET---------------------REQWDDGNNVVLEPGVVVGY---------DR------AGVEVITISASG-GGH-----------------------------------------------CTCPIV

             EPI-EGVIFYGDT--DWFMLGLRDGRPEIQLHNHAQLTVGAGPRL------------------------------------------------------------DG-----------------------RWHQVEVKMEGDSVLLEVD----GEELRLRQV-------------------------------------------------------------------------LP------------------------------VPALDGCLR

                                                        ASKQGVGTA-SKVWFTLANGAISEVYIDTADVKEIKF-ETKDA-ISKVEKF-KSLGYKLVNTDKKGRYRI-------------------------------------------------------------------TKDIFTDVKRNSLIMKA--K--------TALSSN

            TGEEDEEEFFCNR---IGNVKILRGKIRLLMRREQVLKIANHYISP----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------MKLTPNASDRSF---HAL----------LPKP--------LAIRFKT

                                                                                                                       LLPRE-------------------ANYLAAIATGDGWGLAFLDVSTGEFKGTVLKSKSA---------------AFL-APFE--PEGAAYATQG

        TPL-----QKSFESTVGQSDMYSYVFRVCRE-----------------------------------------------------------SG------------------------AGLVQIQKSNGKETVVGRF-------FQGSNWI----KGGDRRASEERGK-----QDCF------------------------MDSSL

         QPGYK-ASG-SSPSTSLSLPYVLANSCKNRLLVAFRGDKSAAYGLQVSL----------KQESD---PNW

                                                                                                                                                                                                   TKEGYLT-TRWFTLHR--NELKYFKDMSPEPIRILDLT--------FDYVNCFC------------------------LVTFYLCAKTGV